Results 61 to 70 of about 538,821 (309)
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Optimization of Multiple Traveling Salesman Problem Based on Simulated Annealing Genetic Algorithm
MATEC Web of Conferences, 2017 It is very effective to solve the multi variable optimization problem by using hierarchical genetic algorithm. This thesis analyzes both advantages and disadvantages of hierarchical genetic algorithm and puts forward an improved simulated annealing ...
Xu Mingji, Li Sheng, Guo Jian
doaj +1 more source
SAIPO-TAIPO and Genetic Algorithms for Investment Portfolios [PDF]
, 2022 Juan Frausto–Solís +4 more
openalex +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
A Novel RPL Algorithm Based on Chaotic Genetic Algorithm
Sensors, 2018 RPL (routing protocol for low-power and lossy networks) is an important candidate routing algorithm for low-power and lossy network (LLN) scenarios. To solve the problems of using a single routing metric or no clearly weighting distribution theory of ...
Yanan Cao, Muqing Wu
doaj +1 more source
Method for Spatial Crowdsourcing Task Assignment Based on Integrating of Genetic Algorithm and Ant Colony Optimization [PDF]
, 2020 Yang Wang, Chenxi Zhao, Shanshan Xu
openalex +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source