Results 91 to 100 of about 813,318 (331)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Practical Production Scheduling for Hot Metal Pretreatment-Steelmaking-Continuous Casting Process Involving Preventive Maintenance Consideration

IEEE Access, 2018
Preventive maintenance is significant for health management of production system, while the maintenance plan is seldom simultaneously considered in the decision-making process of production scheduling. This paper studies a practical production scheduling
Jianyu Long, Ying Hong, Yun Bai, Shaohui Zhang, Zhenzhong Sun   +4 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Fuzzy Adaptive Genetic Algorithm for Improving the Solution of Industrial Optimization Problems

Journal of Intelligent Systems, 2018
In the industrial and manufacturing fields, many problems require tuning of the parameters of complex models by means of exploitation of empirical data.
Vannucci Marco, Colla Valentina, Dettori Stefano, Iannino Vincenzo   +3 more
doaj   +1 more source

Results of Evolution Supervised by Genetic Algorithms

, 2010
A series of results of evolution supervised by genetic algorithms with interest to agricultural and horticultural fields are reviewed. New obtained original results from the use of genetic algorithms on structure-activity relationships are reported ...
Lorentz JÄNTSCHI, Mircea V. DIUDEA, Mugur C. BĂLAN, Radu E. SESTRAS, Sorana D. BOLBOACĂ   +4 more
core   +3 more sources

A Genetic Algorithm Tool (splicer) for Complex Scheduling Problems and the Space Station Freedom Resupply Problem [PDF]

, 1993
The Space Station Freedom will require the supply of items in a regular fashion. A schedule for the delivery of these items is not easy to design due to the large span of time involved and the possibility of cancellations and changes in shuttle flights ...
Valenzuela-Rendon, Manuel, Wang, Lui
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Genetic algorithms [PDF]

Genetic algorithms are mathematical, highly parallel, adaptive search procedures (i.e., problem solving methods) based loosely on the processes of natural genetics and Darwinian survival of the fittest.
Bayer, Steven E., Wang, Lui
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Operator Kawin Silang pada Algoritma Genetik Riil untuk Variabel Rencana Selalu Positif

Media Komunikasi Teknik Sipil, 2016
Genetic algorithms have been used to solve various optimization problems. One of the advantages of genetic algorithms is that they have the ability to solve complex optimization problems in a simple way.
Yoyong Arfiadi
doaj   +1 more source