Results 201 to 210 of about 115,560 (262)

Wide-scale geographical analysis of genetic ancestry in the South African Coloured population. [PDF]

BMC Biol
Lankheet I, Hammarén R, Alva Caballero LX, Larena M, Malmström H, Jolly C, Soodyall H, de Jongh M, Schlebusch C.   +8 more
europepmc   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

AncestryGeni: a novel genetic ancestry classification pipeline for small and noisy sequence data. [PDF]

Bioinformatics
Elhaik E, Behnamian S, Howe M, Tang H, Yan H, Tian S, Shivaram S, Zepeda Mendoza C, MacLachlan K, Usmani S, Pirooznia M, Morgan G, Blaney P, Maura F, Baughn LB.   +14 more
europepmc   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

The impact of genetic ancestry on survival outcomes in pediatric rhabdomyosarcoma: A report from the Children's Oncology Group. [PDF]

HGG Adv
Onwuka EA, Magyar CL, Martin-Giacalone BA, Scheurer ME, Marquez-Do DA, Zobeck M, Atkinson EG, Rudzinski ER, Arnold MA, Barkauskas DA, Hall D, Khan J, Shern JF, Scheet P, Crompton B, Linardic CM, Hawkins DS, Venkatramani R, Mirabello L, Huff CD, Richard MA, Lupo PJ.   +21 more
europepmc   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

[Genetic ancestry and the SNP RS4988235 of lactose tolerance in the population of Lima]. [PDF]

Rev Peru Med Exp Salud Publica
Vladimir Flores S, Roco-Videla Á, Montaña RM.   +2 more
europepmc   +1 more source

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, EarlyView.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source

Genetic Ancestry, Intrinsic Tumor Subtypes, and Breast Cancer Survival in Latin American Women. [PDF]

Cancer Res Commun
Alves da Quinta D, Rocha D, Yáñez C, Binato R, Soares-Lima SC, Huang X, Ganiewich D, Zavala VA, Sans M, Lopez-Vazquez A, Quintero J, Valenzuela O, Quintero-Ramos A, Del Toro-Arreola A, Cerda M, Marcelain K, Crocamo S, Nagai MA, Carraro DM, Marques MMC, Gómez J, Artagaveytia N, Daneri-Navarro A, Müller BG, Retamales J, Velazquez C, Fernández EA, Podhajcer OL, Abdelhay E, Verdugo RA, LACRN Investigators, Llera AS, Fejerman L.   +32 more
europepmc   +1 more source