Results 101 to 110 of about 8,825,337 (378)

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Nature Genetics, 2017
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified ...
N. Wray, S. Ripke, M. Mattheisen, M. Trzaskowski, Enda M. Byrne, A. Abdellaoui, Mark J Adams, E. Agerbo, T. Air, Till F. M. Andlauer, S. Bacanu, Marie Bækvad-Hansen, A. Beekman, T. Bigdeli, E. Binder, D. Blackwood, J. Bryois, H. Buttenschøn, J. Bybjerg-Grauholm, N. Cai, E. Castelao, J. Christensen, Toni‐Kim Clarke, Jonathan R. I. Coleman, L. Colodro-Conde, B. Couvy-Duchesne, N. Craddock, Gregory E. Crawford, Cheynna A. Crowley, Hassan S. Dashti, G. Davies, I. Deary, F. Degenhardt, E. Derks, N. Direk, Conor V. Dolan, Erin C. Dunn, T. Eley, N. Eriksson, V. Escott-Price, Farnush Farhadi Hassan Kiadeh, H. Finucane, A. Forstner, J. Frank, Héléna A. Gaspar, M. Gill, P. Giusti-Rodríguez, F. Goes, Scott D. Gordon, J. Grove, L. Hall, E. Hannon, C. Hansen, Thomas F. Hansen, S. Herms, Ian B. Hickie, P. Hoffmann, G. Homuth, Carsten Horn, J. Hottenga, D. Hougaard, Ming Hu, Craig L Hyde, M. Ising, R. Jansen, Fulai Jin, E. Jorgenson, J. A. Knowles, Isaac S. Kohane, J. Kraft, Warren W. Kretzschmar, J. Krogh, Z. Kutalik, J. Lane, Yihan Li, Yun Li, P. Lind, Xiaoxiao Liu, Leina Lu, D. Macintyre, D. MacKinnon, Robert M. Maier, W. Maier, J. Marchini, H. Mbarek, P. McGrath, P. McGuffin, S. Medland, D. Mehta, C. Middeldorp, E. Mihailov, Y. Milaneschi, L. Milani, J. Mill, Francis M. Mondimore, Grant W. Montgomery, S. Mostafavi, N. Mullins, M. Nauck, B. Ng, M. Nivard, D. Nyholt, Paul F. O’Reilly, H. Oskarsson, Michael J. Owen, J. Painter, C. B. Pedersen, M. Pedersen, Roseann E. Peterson, E. Pettersson, W. Peyrot, G. Pistis, D. Posthuma, Shaun Purcell, Jorge A. Quiroz, P. Qvist, John P. Rice, B. Riley, M. Rivera, Saira Saeed Mirza, R. Saxena, R. Schoevers, E. Schulte, L. Shen, Jianxin Shi, Stanley I. Shyn, E. Sigurdsson, Grant C. B. Sinnamon, Johannes H. Smit, Daniel J. Smith, H. Stefánsson, S. Steinberg, C. Stockmeier, F. Streit, J. Strohmaier, K. Tansey, H. Teismann, A. Teumer, W. Thompson, P. Thomson, T. Thorgeirsson, C. Tian, M. Traylor, J. Treutlein, V. Trubetskoy, A. Uitterlinden, D. Umbricht, S. Van der Auwera, A. V. van Hemert, A. Viktorin, P. M. Visscher, Yunpeng Wang, B. Webb, S. Weinsheimer, J. Wellmann, G. Willemsen, S. Witt, Yang Wu, H. Xi, Jian Yang, Futao Zhang, V. Arolt, Bernhard T. Baune, K. Berger, D. Boomsma, S. Cichon, U. Dannlowski, E. D. de Geus, J. DePaulo, E. Domenici, K. Domschke, T. Esko, H. Grabe, S. Hamilton, C. Hayward, A. C. Heath, D. Hinds, K. Kendler, S. Kloiber, G. Lewis, Qingqin S Li, S. Lucae, P. Madden, Patrik K. E. Magnusson, Nicholas G. Martin, Andrew M. McIntosh, A. Metspalu, O. Mors, P. Mortensen, B. Müller-Myhsok, M. Nordentoft, M. Nöthen, M. O’Donovan, S. Paciga, Nancy L Pedersen, B. Penninx, R. Perlis, D. Porteous, J. Potash, M. Preisig, M. Rietschel, C. Schaefer, T. G. Schulze, J. Smoller, K. Stefánsson, H. Tiemeier, R. Uher, H. Völzke, Myrna M Weissman, T. Werge, Ashley R. Winslow, C. Lewis, D. Levinson, G. Breen, A. Børglum, P. Sullivan   +215 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Genetic Syndromes Associated with Craniosynostosis

Journal of Korean Neurosurgical Society, 2016
Craniosynostosis is defined as the premature fusion of one or more of the cranial sutures. It leads not only to secondary distortion of skull shape but to various complications including neurologic, ophthalmic and respiratory dysfunction. Craniosynostosis is very heterogeneous in terms of its causes, presentation, and management.
openaire   +3 more sources

Guilt by Genetic Association

Journal of Sports Medicine & Doping Studies, 2015
Michael R. Graham1, Bruce Davies2 and Julien S. Baker*3 1Llantarnam Health Care, Parc-y-Bont, UK 2Department of Health and Exercise Science, University of South Wales, UK 3Department of Health and Exercise Science, University of the West of Scotland, UK *Corresponding author: Julien S Baker, Professor, Department of Health and Exercise Science ...
Bruce Davies, Michael R. Graham, Julien S. Baker   +2 more
openaire   +2 more sources

Assessing the quality of published genetic association studies in meta-analyses: the quality of genetic studies (Q-Genie) tool

BMC Genetics, 2015
Advances in genomics technology have led to a dramatic increase in the number of published genetic association studies. Systematic reviews and meta-analyses are a common method of synthesizing findings and providing reliable estimates of the effect of a ...
Z. Sohani, D. Meyre, R. D. de Souza, P. Joseph, Mandark Gandhi, B. Dennis, G. Norman, Sonia S Anand   +7 more
semanticscholar   +1 more source

The Relationship Between Environmental Exposure and Genetic Architecture of the 2q33 Locus With Esophageal Cancer in South Africa

Frontiers in Genetics, 2019
Esophageal squamous cell carcinoma (ESCC) has a high prevalence in several countries in Africa and Asia. Previous genome-wide association studies (GWAS) in Chinese populations have identified several ESCC susceptibility loci, including variants on ...
Marco Matejcic, Christopher G. Mathew, Christopher G. Mathew, M. Iqbal Parker   +3 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Impact of Interleukin-17 Receptor A Gene Variants on Asthma Susceptibility and Clinical Manifestations in Children and Adolescents

Children
Several single nucleotide polymorphisms (SNPs) in multiple interleukin receptor genes could be associated with asthma risk and/or phenotype. Interleukin-17 (IL-17) has been implicated in tissue inflammation and autoimmune diseases. As no previous studies
Shymaa Ahmed Maher, Nouran B. AbdAllah, Essam Al Ageeli, Eman Riad, Shahad W. Kattan, Sherouk Abdelaal, Wagdy Abdelfatah, Gehan A. Ibrahim, Eman A. Toraih, Ghada A. Awadalla, Manal S. Fawzy, Ahmed Ibrahim   +11 more
doaj   +1 more source