Results 101 to 110 of about 7,627,088 (344)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Functional mapping and annotation of genetic associations with FUMA

Nature Communications, 2017
A main challenge in genome-wide association studies (GWAS) is to pinpoint possible causal variants. Results from GWAS typically do not directly translate into causal variants because the majority of hits are in non-coding or intergenic regions, and the ...
Kyoko Watanabe, E. Taskesen, Arjen van Bochoven, D. Posthuma   +3 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort.

JAMA psychiatry, 2019
Importance The origins and development of autism spectrum disorder (ASD) remain unresolved. No individual-level study has provided estimates of additive genetic, maternal, and environmental effects in ASD across several countries. Objective To estimate
Dan Bai, B. Yip, G. Windham, A. Sourander, R. Francis, R. Yoffe, E. Glasson, B. Mahjani, Auli Suominen, H. Leonard, M. Gissler, J. Buxbaum, Kingsley Wong, D. Schendel, A. Kodesh, M. Breshnahan, S. Levine, E. Parner, S. N. Hansen, C. Hultman, A. Reichenberg, S. Sandin   +21 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Observational and genetic analyses clarify the relationship between type 2 diabetes mellitus and gallstone disease

Frontiers in Endocrinology
BackgroundThe relationship between type 2 diabetes mellitus (T2DM) and gallstone disease (GSD) have been incompletely understood. We aimed to investigate their phenotypic and genetic associations and evaluate the biological mechanisms underlying these ...
Peijing Yan, Li Zhang, Chao Yang, Chao Yang, Wenqiang Zhang, Yutong Wang, Min Zhang, Huijie Cui, Mingshuang Tang, Lin Chen, Xueyao Wu, Xunying Zhao, Yanqiu Zou, Jinyu Xiao, Yunjie Liu, Chenghan Xiao, Yanfang Yang, Ling Zhang, Yuqin Yao, Jiayuan Li, Zhenmi Liu, Chunxia Yang, Xia Jiang, Xia Jiang, Xia Jiang, Ben Zhang, Ben Zhang   +26 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Research of caspase-dependent mechanisms of apoptosis induction and the activity of peroxidation and antioxidant defense in the thyroid tissue of patients with nodular forms of goiter combined with autoimmune thyroiditis and thyroid adenoma depending on the allelic status of Bcl-2 (rs17759659), CTLA-4 (rs231775), APO-1 / Fas (rs2234767) genes

Journal of Education, Health and Sport, 2017
The aim of the work is to analyze the mechanisms of caspase-dependent apoptosis and pro- and antioxidant activity in the thyroid tissue homogenate in patients with in patients with nodular goiter with autoimmune thyroiditis and thyroid adenoma ...
M. I. Sheremet
doaj  

Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese [PDF]

, 2010
Jie Liu, Bao Song, Xueli bai, Wenjian Liu, Zengjun Li, Jia‐Lin Wang, Yan Zheng, Zhehai Wang   +7 more
openalex   +1 more source

Validation in Genetic Association Studies [PDF]

Briefings in Bioinformatics, 2011
Validation of genetic associations is understood to be a cornerstone for the scientific credibility of the results. To approach this topic, the general concept of genetic association studies is introduced briefly, followed by how the term 'validation' is used in the context of genetic association studies.
openaire   +2 more sources