Results 141 to 150 of about 8,691,632 (395)

High loading of polygenic risk for ADHD in children with comorbid aggression [PDF]

, 2013
Objective: Although attention deficit hyperactivity disorder (ADHD) is highly heritable, genome-wide association studies (GWAS) have not yet identified any common genetic variants that contribute to risk.
Agha, SS, Anney, RJL, Asherson, P, Banaschewski, T, Barke, Edmund, Biederman, J, Buitelaar, J, Doyle, AE, Faraone, SV, Franke, B, Freitag, C, Hakonarson, H, Hamshere, ML, Holmans, P, Kent, L, Kuntsi, J, Lambregts-Rommelse, N, Langley, K, Lesch, KP, Martin, J, McGough, JJ, Medland, SE, Merwood, A, Meyer, J, Neale, BM, O'Donovan, MC, Oades, RD, Owen, MJ, Palmason, H, Reif, A, Renner, TJ, Ripke, S, Roeyers, Herbert, Romanos, J, Romanos, M, Rothenberger, A, Steinhausen, HC, Stergiakouli, E, Thapar, A, Vasquez, AA, Warnke, A, Williams, N   +41 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Meta-analyses of Blood Homocysteine Levels for Gender and Genetic Association Studies of the MTHFR C677T Polymorphism in Schizophrenia

Schizophrenia bulletin, 2014
Previous studies suggest that elevated blood homocysteine levels and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism are risk factors for schizophrenia.
Akira Nishi, Shusuke Numata, A. Tajima, M. Kinoshita, Kumiko Kikuchi, S. Shimodera, M. Tomotake, K. Ohi, R. Hashimoto, I. Imoto, M. Takeda, T. Ohmori   +11 more
semanticscholar   +1 more source

Analysis of SIRT1 genetic variants in young Mexican individuals: relationships with overweight and obesity

Frontiers in Genetics
The high prevalence of obesity in Mexico starting from the early stages of life is concerning and represents a major public health problem. Genetic association studies have reported that single nucleotide variants (SNVs) in SIRT1, an NAD+-dependent ...
S. Salazar-García, A. Ibáñez-Salazar, E. Lares-Villaseñor, Noemi Gaytan Pacheco, E. Uresti-Rivera, D. P. Portales-Pérez, U. De la Cruz-Mosso, J. M. Vargas-Morales   +7 more
doaj   +1 more source

Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population

Genetics and Molecular Biology, 2017
Genome-wide association studies have identified several loci associated with an increased risk for cardiovascular disease (CVD) and type 2 diabetes (T2D). Polymorphisms within the KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) gene
Maha S. Al-Shammari, Rhaya Al-Ali, Nader Al-Balawi, Mansour S. Al-Enazi, Ali A. Al-Muraikhi, Fadi N. Busaleh, Ali S. Al-Sahwan, Abdulmohsen Al-Elq, Awatif N. Al-Nafaie, Jesu Francis Borgio, Sayed AbdulAzeez, Amein Al-Ali, Sadananda Acharya   +12 more
doaj   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

An Atlas of Genetic Correlations across Human Diseases and Traits

Nature Genetics, 2015
Identifying genetic correlations between complex traits and diseases can provide useful etiological insights and help prioritize likely causal relationships.
B. Bulik-Sullivan, H. Finucane, V. Anttila, A. Gusev, F. Day, Po-Ru Loh, L. Duncan, J. Perry, N. Patterson, E. Robinson, M. Daly, A. Price, B. Neale   +12 more
semanticscholar   +1 more source

Genetic Control of the Immune Response in Mice. III. An Association between H-2 Type and Reaction to H-Y [PDF]

, 1971
David L. Gasser, Willys K. Silvers
openalex   +1 more source

HARDY-WEINBERG EQUILIBRIUM ASSUMPTIONS IN CASE-CONTROL TESTS OF GENETIC ASSOCIATION [PDF]

, 2009
The case-control study design is commonly used in genetic association study with a binary trait using unrelated individuals from a population. To test association with a binary trait in a case-control or cohort study, the standard analysis is a chi ...
Lee, Myoungkeun
core  

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source