Results 11 to 20 of about 2,748,088 (370)

GemTools: A fast and efficient approach to estimating genetic ancestry [PDF]

arXiv, 2011
To uncover the genetic basis of complex disease, individuals are often measured at a large number of genetic variants (usually SNPs) across the genome. GemTools provides computationally efficient tools for modeling genetic ancestry based on SNP genotypes.
Devlin, Bernie, Kent, Brian P., Klei, Lambertus, Melhem, Nadine, Roeder, Kathryn   +4 more
core   +1 more source

Monitoring of environmental gases and calf health in Italian Mediterranean buffalo herd

Revista Científica, 2023
In buffalo breeding, calves require special attention and housing systems that provide thermal comfort, good air quality, brightness, and adequate space.
Simona Leonetti , Monica Ambrosio , Mirko Scamardella , Chiara Caso , Angelo Coletta   +4 more
doaj   +1 more source

Expert Consensus on Clinical Specimen Preservation and Biosafety Protection in the Context of Managing COVID-19 with Measures against Class B Infectious Diseases

Xiehe Yixue Zazhi, 2023
During the past three years, the national prevention and control policies for coronavirus disease 2019(COVID-19) have gone from'Class A control' to 'Class B control'.
Clinical Data and Biobank Committee of China Research Hospital Association, Guangdong Human Genetic Resource Biobanking and Applications Association   +1 more
doaj   +1 more source

Fine-mapping genetic associations [PDF]

Human Molecular Genetics, 2020
AbstractWhilst thousands of genetic variants have been associated with human traits, identifying the subset of those variants that are causal requires a further ‘fine-mapping’ step. We review the basic fine-mapping approach, which is computationally fast and requires only summary data, but depends on an assumption of a single causal variant per ...
Hutchinson, Anna, Asimit, Jennifer, Wallace, Chris   +2 more
openaire   +3 more sources

Rare and common variant discovery by whole-genome sequencing of 101 Thoroughbred racehorses

Scientific Reports, 2021
The Thoroughbred breed was formed by crossing Oriental horse breeds and British native horses and is currently used in horseracing worldwide. In this study, we constructed a single-nucleotide variant (SNV) database using data from 101 Thoroughbred ...
Teruaki Tozaki, Aoi Ohnuma, Mio Kikuchi, Taichiro Ishige, Hironaga Kakoi, Kei-ichi Hirota, Kanichi Kusano, Shun-ichi Nagata   +7 more
doaj   +1 more source

Variable Effects of PD-Risk Associated SNPs and Variants in Parkinsonism-Associated Genes on Disease Phenotype in a Community-Based Cohort

Frontiers in Neurology, 2021
Genetic risk factors for Parkinson's disease (PD) risk and progression have been identified from genome-wide association studies (GWAS), as well as studies of familial forms of PD, implicating common variants at more than 90 loci and pathogenic or likely
Katerina Markopoulou, Bruce A. Chase, Ashvini P. Premkumar, Bernadette Schoneburg, Ninith Kartha, Jun Wei, Hongjie Yu, Alexander Epshteyn, Lisette Garduno, Anna Pham, Rosa Vazquez, Roberta Frigerio, Demetrius Maraganore   +12 more
doaj   +1 more source

Systematic Review of Genomic Associations with Blood Pressure and Hypertension in Populations with African-Ancestry

Frontiers in Genetics, 2021
Background: Despite hypertension being highly prevalent in individuals with African-ancestry, they are under-represented in large genome-wide association studies.
S. Singh, S. Singh, J-T. Brandenburg, A. Choudhury, F.X. Gómez-Olivé, M. Ramsay, M. Ramsay   +6 more
doaj   +1 more source

Depression in systemic lupus erythematosus: Modifiable or inheritable? a two-sample mendelian randomization study

Frontiers in Genetics, 2022
Observational studies have found increased incidence of depression, the leading cause of disability worldwide, in patients with systemic lupus erythematosus (SLE).
Jinyun Chen, Ting Xu, Min Wu
doaj   +1 more source

The anatomical distribution of genetic associations [PDF]

Nucleic Acids Research, 2015
AbstractDeeper understanding of the anatomical intermediaries for disease and other complex genetic traits is essential to understanding mechanisms and developing new interventions. Existing ontology tools provide functional annotations for many genes in the genome and they are widely used to develop mechanistic hypotheses based on genetic and ...
Wells, Alan, Kopp, Nathan, Xu, Xiaoxiao, O'Brien, David R, Yang, Wei, Nehorai, Arye, Adair-Kirk, Tracy L, Kopan, Raphael, Dougherty, J D   +8 more
openaire   +5 more sources

Genetic variants associated with sepsis

PLOS ONE, 2022
Background The variable presentations and different phenotypes of sepsis suggest that risk of sepsis comes from many genes each having a small effect. The cumulative effect can be used to create individual risk profile. The purpose of this study was to create a polygenic risk score and determine the genetic variants associated with sepsis.
Milo Engoren, Elizabeth S. Jewell, Nicholas Douville, Stephanie Moser, Michael D. Maile, Melissa E. Bauer   +5 more
openaire   +4 more sources