Results 11 to 20 of about 7,627,088 (344)

Genetic Polymorphism of PTPN22 in Autoimmune Diseases: A Comprehensive Review

Medicina, 2022
It is known that the etiology and clinical outcomes of autoimmune diseases are associated with a combination of genetic and environmental factors. In the case of the genetic factor, the SNPs of the PTPN22 gene have shown strong associations with several ...
Kalthoum Tizaoui, Jae Il Shin, Gwang Hun Jeong, Jae Won Yang, Seoyeon Park, Ji Hong Kim, Soo Young Hwang, Se Jin Park, Ai Koyanagi, Lee Smith   +9 more
doaj   +1 more source

Evaluation of the Genetic Diversity of Greek Garlic (Allium sativum L.) Accessions Using DNA Markers and Association with Phenotypic and Chemical Variation

Agriculture, 2023
The genetic diversity of 27 garlic accessions (local varieties/landraces) was investigated using five simple sequence repeat (SSR) and six inter-simple sequence repeat (ISSR) markers. The SSR genotyping revealed 26 different alleles, while 84 polymorphic
Charikleia Papaioannou, Georgia Fassou, Spyridon A. Petropoulos, Fotini N. Lamari, Penelope J. Bebeli, Vasileios Papasotiropoulos   +5 more
doaj   +1 more source

Power and Sample Size Calculations for Genetic Association Studies in the Presence of Genetic Model Misspecification

Human Heredity, 2020
Introduction: When analyzing data from large-scale genetic association studies, such as targeted or genome-wide resequencing studies, it is common to assume a single genetic model, such as dominant or additive, for all tests of association between a ...
Camille M. Moore, Sean Jacobson, T. Fingerlin   +2 more
semanticscholar   +1 more source

Genetic Association between TNFA Polymorphisms (rs1799964 and rs361525) and Susceptibility to Cancer in Systemic Sclerosis

Life, 2022
Tumor necrosis factor (TNF)-α is a proinflammatory cytokine that plays an important role in the pathogenesis of autoimmune diseases. The aim of the study was to establish an association between TNF-α promoter variability and systemic sclerosis (SSc). The
Joanna Kosałka-Węgiel, Sabina Lichołai, Sylwia Dziedzina, Mamert Milewski, Piotr Kuszmiersz, Anna Rams, Jolanta Gąsior, Aleksandra Matyja-Bednarczyk, Helena Kwiatkowska, Mariusz Korkosz, Andżelika Siwiec, Paweł Koźlik, Agnieszka Padjas, Wojciech Sydor, Jerzy Dropiński, Marek Sanak, Jacek Musiał, Stanisława Bazan-Socha   +17 more
doaj   +1 more source

Genetic association of FMRP targets with psychiatric disorders

bioRxiv, 2020
Genes encoding the mRNA targets of Fragile X mental retardation protein (FMRP) are enriched for genetic association with psychiatric disorders. However, many FMRP targets possess functions that are themselves genetically associated with psychiatric ...
N. Clifton, E. Rees, P. Holmans, A. Pardiñas, J. Harwood, A. Di Florio, G. Kirov, J. Walters, M. O’Donovan, M. Owen, J. Hall, A. Pocklington   +11 more
semanticscholar   +1 more source

Association between DRD4 rs1800955 polymorphism and Attention Deficit Hyperactivity Disorder susceptibility among children from Northwest of Iran: a case-control study [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2021
Background: Attention deficit hyperactivity disorder (ADHD) is the most common and highly heritable psychiatric disorder among children which affects 3-7% of them all around the world. ADHD characterized by some symptoms such as extreme and inappropriate
Nava Khalilinejad, Leila Mehdizadeh Fanid, Narges Zeinalzadeh, Maedeh Alizadeh   +3 more
doaj   +1 more source

Development and pilot testing of a three-dimensional, phenomenon-based unit that integrates evolution and heredity

Evolution: Education and Outreach, 2019
To realize the promise of the Next Generation Science Standards, educators require new three-dimensional, phenomenon-based curriculum materials. We describe and report on pilot test results from such a resource—Evolution: DNA and the Unity of Life ...
Sheila A. Homburger, Dina Drits-Esser, Molly Malone, Kevin Pompei, Kagan Breitenbach, Ryan D. Perkins, Pete C. Anderson, Nicola C. Barber, Amy J. Hawkins, Sam Katz, Max Kelly, Harmony Starr, Kristin M. Bass, Jo Ellen Roseman, Joseph Hardcastle, George DeBoer, Louisa A. Stark   +16 more
doaj   +1 more source

Genetic Association Studies [PDF]

Circulation, 2008
With the completion of the HapMap project1 and the development of technology that allows the examination of ≥1 million genetic polymorphisms at once, genetic association studies are becoming more comprehensive. This article first provides a brief overview of the rationale for genetic association studies; it then discusses the primary features ...
openaire   +2 more sources

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

Nature Genetics, 2017
In genome-wide association studies (GWAS) for thousands of phenotypes in large biobanks, most binary traits have substantially fewer cases than controls.
W. Zhou, J. Nielsen, L. Fritsche, Rounak Dey, M. Gabrielsen, B. Wolford, J. Lefaive, Peter Vandehaar, Sarah A Gagliano, A. Gifford, L. Bastarache, Wei-Qi Wei, J. Denny, Maoxuan Lin, K. Hveem, H. Kang, G. Abecasis, C. Willer, Seunggeun Lee   +18 more
semanticscholar   +1 more source

Genetic association testing using the GENESIS R/Bioconductor package

Bioinform., 2019
SUMMARY The Genomic Data Storage (GDS) format provides efficient storage and retrieval of genotypes measured by microarrays and sequencing. We developed GENESIS to perform various single- and aggregate-variant association tests using genotype data stored
S. Gogarten, T. Sofer, Han Chen, Chaoyu Yu, J. Brody, T. Thornton, K. Rice, M. Conomos   +7 more
semanticscholar   +1 more source