Results 11 to 20 of about 8,691,632 (395)
LocusZoom.js: interactive and embeddable visualization of genetic association study results
bioRxiv, 2021 LocusZoom.js is a JavaScript library for creating interactive web-based visualizations of genetic association study results. It can display one or more traits in the context of relevant biological data (such as gene models and other genomic annotation ...
Andrew P. Boughton +6 more
semanticscholar +1 more source
Orogenic gold: is a genetic association with magmatism realistic?
Mineralium Deposita, 2022 Many workers accept a metamorphic model for orogenic gold ore formation, where a gold-bearing aqueous-carbonic fluid is an inherent product of devolatilization across the greenschist-amphibolite boundary with the majority of deposits formed within the ...
R. Goldfarb, I. Pitcairn
semanticscholar +1 more source
Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics [PDF]
PLoS Genetics, 2013 Genetic association studies, in particular the genome-wide association study (GWAS) design, have provided a wealth of novel insights into the aetiology of a wide range of human diseases and traits, in particular cardiovascular diseases and lipid ...
C. Giambartolomei +6 more
semanticscholar +1 more source
Human Heredity, 2020 Introduction: When analyzing data from large-scale genetic association studies, such as targeted or genome-wide resequencing studies, it is common to assume a single genetic model, such as dominant or additive, for all tests of association between a ...
Camille M. Moore +2 more
semanticscholar +1 more source
Genetic association of FMRP targets with psychiatric disorders
bioRxiv, 2020 Genes encoding the mRNA targets of Fragile X mental retardation protein (FMRP) are enriched for genetic association with psychiatric disorders. However, many FMRP targets possess functions that are themselves genetically associated with psychiatric ...
N. Clifton +11 more
semanticscholar +1 more source
Genetic Alterations Associated With Cryptorchidism [PDF]
JAMA, 2008 Cryptorchidism is the most frequent congenital birth defect in male children and represents an important risk factor for infertility and testicular cancer. Major regulators of testicular descent are the hormones insulin-like factor 3 (INSL3) and testosterone, and disruption of these pathways might cause cryptorchidism.To determine the frequency of ...
FERLIN, ALBERTO +5 more
openaire +6 more sources
Genetic model misspecification in genetic association studies [PDF]
BMC Research Notes, 2017 The underlying model of the genetic determinant of a trait is generally not known with certainty a priori. Hence, in genetic association studies, a dominant model might be erroneously modelled as additive, an error investigated previously. We explored this question, for candidate gene studies, by evaluating the sample size required to compensate for ...
Amadou Gaye, Sharon K. Davis
openaire +4 more sources
FinnGen provides genetic insights from a well-phenotyped isolated population
Nature, 2023 Genome-wide association studies of individuals from an isolated population (data from the Finnish biobank study FinnGen) and consequent meta-analyses facilitate the identification of previously unknown coding variant associations for both rare and common
M. Kurki +167 more
semanticscholar +1 more source
Cytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association study [PDF]
, 2016 BACKGROUND The inflammatory cytokine cascade is implicated in the pathogenesis of necrotising enterocolitis (NEC). Genetic association studies of cytokine polymorphisms may help to detect molecular mechanisms that are causally related to the disease ...
Baier, R. J. +5 more
core +1 more source
Evolving temporal association rules with genetic algorithms [PDF]
, 2010 A novel framework for mining temporal association rules by discovering itemsets with a genetic algorithm is introduced. Metaheuristics have been applied to association rule mining, we show the efficacy of extending this to another variant - temporal ...
A. Ghandar +11 more
core +2 more sources