Results 11 to 20 of about 8,825,337 (378)
LocusZoom.js: interactive and embeddable visualization of genetic association study results
bioRxiv, 2021 LocusZoom.js is a JavaScript library for creating interactive web-based visualizations of genetic association study results. It can display one or more traits in the context of relevant biological data (such as gene models and other genomic annotation ...
Andrew P. Boughton +6 more
semanticscholar +1 more source
Orogenic gold: is a genetic association with magmatism realistic?
Mineralium Deposita, 2022 Many workers accept a metamorphic model for orogenic gold ore formation, where a gold-bearing aqueous-carbonic fluid is an inherent product of devolatilization across the greenschist-amphibolite boundary with the majority of deposits formed within the ...
R. Goldfarb, I. Pitcairn
semanticscholar +1 more source
Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics [PDF]
PLoS Genetics, 2013 Genetic association studies, in particular the genome-wide association study (GWAS) design, have provided a wealth of novel insights into the aetiology of a wide range of human diseases and traits, in particular cardiovascular diseases and lipid ...
C. Giambartolomei +6 more
semanticscholar +1 more source
Fine-mapping genetic associations [PDF]
Human Molecular Genetics, 2020 AbstractWhilst thousands of genetic variants have been associated with human traits, identifying the subset of those variants that are causal requires a further ‘fine-mapping’ step. We review the basic fine-mapping approach, which is computationally fast and requires only summary data, but depends on an assumption of a single causal variant per ...
Hutchinson, Anna +2 more
openaire +3 more sources
Genome-wide association analysis of plasma lipidome identifies 495 genetic associations
medRxiv, 2023 Human plasma lipidome captures risk for cardio-metabolic diseases. To discover new lipid-associated variants and understand link between lipid species and cardiometabolic disorders, we performed univariate and multivariate genome-wide analyses of 179 ...
L. Ottensmann +8 more
semanticscholar +1 more source
Human Heredity, 2020 Introduction: When analyzing data from large-scale genetic association studies, such as targeted or genome-wide resequencing studies, it is common to assume a single genetic model, such as dominant or additive, for all tests of association between a ...
Camille M. Moore +2 more
semanticscholar +1 more source
Genetic variants associated with sepsis
PLOS ONE, 2022 Background The variable presentations and different phenotypes of sepsis suggest that risk of sepsis comes from many genes each having a small effect. The cumulative effect can be used to create individual risk profile. The purpose of this study was to create a polygenic risk score and determine the genetic variants associated with sepsis.
Milo Engoren +5 more
openaire +4 more sources
The anatomical distribution of genetic associations [PDF]
Nucleic Acids Research, 2015 AbstractDeeper understanding of the anatomical intermediaries for disease and other complex genetic traits is essential to understanding mechanisms and developing new interventions. Existing ontology tools provide functional annotations for many genes in the genome and they are widely used to develop mechanistic hypotheses based on genetic and ...
Wells, Alan +8 more
openaire +5 more sources
Genetic association of FMRP targets with psychiatric disorders
bioRxiv, 2020 Genes encoding the mRNA targets of Fragile X mental retardation protein (FMRP) are enriched for genetic association with psychiatric disorders. However, many FMRP targets possess functions that are themselves genetically associated with psychiatric ...
N. Clifton +11 more
semanticscholar +1 more source