Results 21 to 30 of about 8,691,632 (395)

Genome-wide association analysis of plasma lipidome identifies 495 genetic associations

medRxiv, 2023
Human plasma lipidome captures risk for cardio-metabolic diseases. To discover new lipid-associated variants and understand link between lipid species and cardiometabolic disorders, we performed univariate and multivariate genome-wide analyses of 179 ...
L. Ottensmann, R. Tabassum, S. Ruotsalainen, M. Gerl, C. Klose, E. Widén, K. Simons, S. Ripatti, M. Pirinen   +8 more
semanticscholar   +1 more source

Development and pilot testing of a three-dimensional, phenomenon-based unit that integrates evolution and heredity

Evolution: Education and Outreach, 2019
To realize the promise of the Next Generation Science Standards, educators require new three-dimensional, phenomenon-based curriculum materials. We describe and report on pilot test results from such a resource—Evolution: DNA and the Unity of Life ...
Sheila A. Homburger, Dina Drits-Esser, Molly Malone, Kevin Pompei, Kagan Breitenbach, Ryan D. Perkins, Pete C. Anderson, Nicola C. Barber, Amy J. Hawkins, Sam Katz, Max Kelly, Harmony Starr, Kristin M. Bass, Jo Ellen Roseman, Joseph Hardcastle, George DeBoer, Louisa A. Stark   +16 more
doaj   +1 more source

Introduction to Genetic Association Studies [PDF]

Cold Spring Harbor Protocols, 2012
Genetic association studies are used to find candidate genes or genome regions that contribute to a specific disease by testing for a correlation between disease status and genetic variation. This article provides a broad outline of the design and analysis of such studies, focusing on case–control studies in candidate genes or regions.
Lewis, Cathryn M, Knight, Jo
openaire   +4 more sources

Genetics of autistic disorders : review and clinical implications [PDF]

, 2009
Twin and family studies in autistic disorders (AD) have elucidated a high heritability of AD. In this literature review, we will present an overview on molecular genetic studies in AD and highlight the most recent findings of an increased rate of copy ...
Duketis, Eftichia, Freitag, Christine M., Klauck, Sabine M., Staal, Wouter, Waltes, Regina   +4 more
core   +4 more sources

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

Nature Genetics, 2017
In genome-wide association studies (GWAS) for thousands of phenotypes in large biobanks, most binary traits have substantially fewer cases than controls.
W. Zhou, J. Nielsen, L. Fritsche, Rounak Dey, M. Gabrielsen, B. Wolford, J. Lefaive, Peter Vandehaar, Sarah A Gagliano, A. Gifford, L. Bastarache, Wei-Qi Wei, J. Denny, Maoxuan Lin, K. Hveem, H. Kang, G. Abecasis, C. Willer, Seunggeun Lee   +18 more
semanticscholar   +1 more source

Heritability estimates of the position and number of facial hair whorls in Thoroughbred horses

BMC Research Notes, 2019
Objective According to oral traditions of horse caretakers and trainers, the differences in the position and number of facial hair whorls may be associated with temperamental traits.
Tamu Yokomori, Teruaki Tozaki, Hiroshi Mita, Takeshi Miyake, Hironaga Kakoi, Yuki Kobayashi, Kanichi Kusano, Takuya Itou   +7 more
doaj   +1 more source

Genetic Association Studies [PDF]

Circulation, 2008
With the completion of the HapMap project1 and the development of technology that allows the examination of ≥1 million genetic polymorphisms at once, genetic association studies are becoming more comprehensive. This article first provides a brief overview of the rationale for genetic association studies; it then discusses the primary features ...
openaire   +2 more sources

Genetics of Anthracycline-Associated Cardiotoxicity

Frontiers in Cardiovascular Medicine, 2022
Anthracyclines are a major component of chemotherapies used in many pediatric and adult malignancies. Anthracycline-associated cardiotoxicity (ACT) is a dose-dependent adverse effect that has substantial impact on morbidity and mortality. Therefore, the identification of genetic variants associated with increased risk of ACT has the potential for ...
Talal Khalid Al-Otaibi, Benjamin Weitzman, Usman A. Tahir, Aarti Asnani   +3 more
openaire   +3 more sources

Psychometric precision in phenotype definition is a useful step in molecular genetic investigation of psychiatric disorders [PDF]

, 2015
Affective disorders are highly heritable, but few genetic risk variants have been consistently replicated in molecular genetic association studies. The common method of defining psychiatric phenotypes in molecular genetic research is either a summation ...
A Brown, A Demirkan, AE Green, BF Voight, CC Minica, DP Goldberg, DP Goldberg, F Samejima, F Stephenson, FF Chen, FV Rijsdijk, HM Kravitz, HW Marsh, HW Marsh, HW Marsh, HW Marsh, HW Marsh, J Liao, JC Barrett, K Hek, K Rousseau, L Hu, LE Duncan, LK Muthén, M Burmeister, M Eid, M Feyder, M Jansson, M Jeon, M Stafford, MEJ Wadsworth, NK Hansell, NR Wray, P McGuffin, P Sklar, P Sullivan, PH Lee, R Plomin, RL Jennrich, RL Jennrich, S Papiol, S Ripke, S van der Sluis, S van der Sluis, S van der Sluis, SE Medland, SP Reise, SP Reise, SP Reise, SP Reise, T Shah, U Reininghaus, U Reininghaus, V Panicker, W Feng, X Fan   +55 more
core   +10 more sources

Detection of phosphorothioated (PS) oligonucleotides in horse plasma using a product ion (m/z 94.9362) derived from the PS moiety for doping control

BMC Research Notes, 2018
Objective Clinical research on gene therapy has advanced the field of veterinary medicine, and gene doping, which is the illegal use of gene therapy, has become a major concern in horseracing. Since the International Federation of Horseracing Authorities
Teruaki Tozaki, Kaoru Karasawa, Yohei Minamijima, Hideaki Ishii, Mio Kikuchi, Hironaga Kakoi, Kei-ichi Hirota, Kanichi Kusano, Shun-ichi Nagata   +8 more
doaj   +1 more source