Results 21 to 30 of about 2,748,088 (370)
ALDH1A1 Genetic Variations May Modulate Risk of Parkinson’s Disease in Han Chinese Population
Frontiers in Neuroscience, 2021 Background: Studies in animal models have suggested that aldehyde dehydrogenase 1 (encoded by ALDH1A1) protects against Parkinson’s disease (PD) by reducing toxic metabolites of dopamine.
Hui-Hui Fan +11 more
doaj +1 more source
Genetic Alterations Associated With Cryptorchidism [PDF]
JAMA, 2008 Cryptorchidism is the most frequent congenital birth defect in male children and represents an important risk factor for infertility and testicular cancer. Major regulators of testicular descent are the hormones insulin-like factor 3 (INSL3) and testosterone, and disruption of these pathways might cause cryptorchidism.To determine the frequency of ...
FERLIN, ALBERTO +5 more
openaire +6 more sources
Genetic model misspecification in genetic association studies [PDF]
BMC Research Notes, 2017 The underlying model of the genetic determinant of a trait is generally not known with certainty a priori. Hence, in genetic association studies, a dominant model might be erroneously modelled as additive, an error investigated previously. We explored this question, for candidate gene studies, by evaluating the sample size required to compensate for ...
Amadou Gaye, Sharon K. Davis
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Evolving temporal association rules with genetic algorithms [PDF]
, 2010 A novel framework for mining temporal association rules by discovering itemsets with a genetic algorithm is introduced. Metaheuristics have been applied to association rule mining, we show the efficacy of extending this to another variant - temporal ...
A. Ghandar +11 more
core +2 more sources
Psychometric precision in phenotype definition is a useful step in molecular genetic investigation of psychiatric disorders [PDF]
, 2015 Affective disorders are highly heritable, but few genetic risk variants have been consistently replicated in molecular genetic association studies. The common method of defining psychiatric phenotypes in molecular genetic research is either a summation ...
A Brown +55 more
core +10 more sources
Genetics of autistic disorders : review and clinical implications [PDF]
, 2009 Twin and family studies in autistic disorders (AD) have elucidated a high heritability of AD. In this literature review, we will present an overview on molecular genetic studies in AD and highlight the most recent findings of an increased rate of copy ...
Duketis, Eftichia +4 more
core +4 more sources
Introduction to Genetic Association Studies [PDF]
Cold Spring Harbor Protocols, 2012 Genetic association studies are used to find candidate genes or genome regions that contribute to a specific disease by testing for a correlation between disease status and genetic variation. This article provides a broad outline of the design and analysis of such studies, focusing on case–control studies in candidate genes or regions.
Lewis, Cathryn M, Knight, Jo
openaire +4 more sources
Population stratification and genetic association studies in South Asia [PDF]
, 2005 Population stratification and its influence on genetic association studies is a controversial topic. Although it has been suggested that stratification is unlikely to bias the results of association studies conducted in developed countries, convincing ...
Bittles, A.H.
core +2 more sources
Evolution: Education and Outreach, 2019 To realize the promise of the Next Generation Science Standards, educators require new three-dimensional, phenomenon-based curriculum materials. We describe and report on pilot test results from such a resource—Evolution: DNA and the Unity of Life ...
Sheila A. Homburger +16 more
doaj +1 more source
Genetics of Anthracycline-Associated Cardiotoxicity
Frontiers in Cardiovascular Medicine, 2022 Anthracyclines are a major component of chemotherapies used in many pediatric and adult malignancies. Anthracycline-associated cardiotoxicity (ACT) is a dose-dependent adverse effect that has substantial impact on morbidity and mortality. Therefore, the identification of genetic variants associated with increased risk of ACT has the potential for ...
Talal Khalid Al-Otaibi +3 more
openaire +3 more sources