Results 51 to 60 of about 7,627,088 (344)

Bayesian Inference for Mixed Model-Based Genome-Wide Analysis of Expression Quantitative Trait Loci by Gibbs Sampling

Frontiers in Genetics, 2019
The importance of expression quantitative trait locus (eQTL) has been emphasized in understanding the genetic basis of cellular activities and complex phenotypes. Mixed models can be employed to effectively identify eQTLs by explaining polygenic effects.
Chaeyoung Lee
doaj   +1 more source

Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project

Diagnostics, 2021
Background: Coronary artery disease (CAD) is a chronic, inflammatory, and complex disease associated with vascular risk factors. Nowadays, the coronary artery calcium (CAC) is a specific marker of the presence and extent of atherosclerosis. Additionally,
Erasmo Zamarrón-Licona, José Manuel Rodríguez-Pérez, Rosalinda Posadas-Sánchez, Gilberto Vargas-Alarcón, Manuel Alfonso Baños-González, Verónica Marusa Borgonio-Cuadra, Nonanzit Pérez-Hernández   +6 more
doaj   +1 more source

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source

Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations

Journal of Epidemiology, 2016
Background: In recent years, several genomic regions have been robustly associated with coronary artery disease (CAD) in different genome-wide association studies (GWASs) conducted mainly in people of European descent.
Daniela Zanetti
doaj   +1 more source

Missense variants in SORT1 are associated with LDL-C in an Amish population

Journal of Lipid Research, 2023
Common noncoding variants at the human 1p13.3 locus associated with SORT1 expression are among those most strongly associated with low-density lipoprotein cholesterol (LDL-C) in human genome-wide association studies.
Kelly A. Mitok, Kathryn L. Schueler, Sarah M. King, Joseph Orr, Kathleen A. Ryan, Mark P. Keller, Ronald M. Krauss, Braxton D. Mitchell, Alan R. Shuldiner, Alan D. Attie   +9 more
doaj   +1 more source

Integrating molecular QTL data into genome-wide genetic association analysis: Probabilistic assessment of enrichment and colocalization

bioRxiv, 2016
We propose a novel statistical framework for integrating genetic data from molecular quantitative trait loci (QTL) mapping into genome-wide genetic association analysis of complex traits, with the primary objectives of quantitatively assessing the ...
Xiaoquan Wen, R. Pique-Regi, Francesca Luca   +2 more
semanticscholar   +1 more source

The MedSupport Multilevel Intervention to Enhance Support for Pediatric Medication Adherence: Development and Feasibility Testing

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction We developed MedSupport, a multilevel medication adherence intervention designed to address root barriers to medication adherence. This study sought to explore the feasibility and acceptability of the MedSupport intervention strategies to support a future full‐scale randomized controlled trial.
Elizabeth G. Bouchard, Hital Patel, Paula C. Vincent, Justine Kahn, Kira Bona, Thai Hoa Tran, Elisa M. Rodriguez, Kristopher Attwood, Kara M. Kelly   +8 more
wiley   +1 more source

Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population

Genetics and Molecular Biology, 2017
Genome-wide association studies have identified several loci associated with an increased risk for cardiovascular disease (CVD) and type 2 diabetes (T2D). Polymorphisms within the KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) gene
Maha S. Al-Shammari, Rhaya Al-Ali, Nader Al-Balawi, Mansour S. Al-Enazi, Ali A. Al-Muraikhi, Fadi N. Busaleh, Ali S. Al-Sahwan, Abdulmohsen Al-Elq, Awatif N. Al-Nafaie, Jesu Francis Borgio, Sayed AbdulAzeez, Amein Al-Ali, Sadananda Acharya   +12 more
doaj   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Nature Genetics, 2018
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery efforts6–11.
Mengzhen Liu, Yu Jiang, Robbee Wedow, Yue Li, D. Brazel, Fang Chen, G. Datta, J. Dávila-Velderrain, Daniel McGuire, C. Tian, Xiaowei Zhan, M. B. A. R. K. K. S. L. P. N. Agee Alipanahi Auton Bell Bryc Elson Fontanillas F, M. Agee, B. Alipanahi, A. Auton, R. Bell, K. Bryc, S. Elson, P. Fontanillas, N. Furlotte, D. Hinds, Bethann S. Hromatka, K. Huber, A. Kleinman, N. Litterman, M. Mcintyre, J. Mountain, C. Northover, J. Sathirapongsasuti, O. Sazonova, J. Shelton, S. Shringarpure, J. Tung, V. Vacic, C. H. Wilson, S. Pitts, Amy Anne Heidi Bendik S. Børge Eystein Gunnar Håvard I Mitchell Skogholt Winsvold Sivertsen Stordal Morke, Amy Mitchell, A. Skogholt, B. Winsvold, Borge Sivertsen, E. Stordal, G. Morken, H. Kallestad, I. Heuch, J. Zwart, K. Fjukstad, L. Pedersen, M. Gabrielsen, M. B. Johnsen, M. Skrove, M. Indredavik, O. K. Drange, O. Bjerkeset, S. Børte, S. Stensland, H. Choquet, A. Docherty, J. Faul, Johanna R. Foerster, L. Fritsche, S. Gordon, J. Haessler, J. Hottenga, Hongyan Huang, Seonkyeong Jang, P. Jansen, Yueh Ling, R. Mägi, N. Matoba, George Mcmahon, A. Mulas, V. Orrù, T. Palviainen, Anita Pandit, Gunnar W. Reginsson, Jennifer A. Smith, Amy E Taylor, Constance Turman, G. Willemsen, Hannah Young, K. Young, G. Zajac, Wei Zhao, Wei Zhou, G. Bjornsdottir, J. Boardman, M. Boehnke, D. Boomsma, Chu Chen, F. Cucca, G. Davies, C. Eaton, M. Ehringer, T. Esko, E. Fiorillo, N. Gillespie, D. Gudbjartsson, T. Haller, K. Harris, A. Heath, J. Hewitt, I. Hickie, J. Hokanson, Christian J. Hopfer, D. Hunter, W. Iacono, Eric O. Johnson, Y. Kamatani, S. Kardia, M. Keller, Manolis Kellis, C. Kooperberg, P. Kraft, K. Krauter, M. Laakso, P. Lind, A. Loukola, S. Lutz, P. Madden, N. Martin, M. McGue, M. McQueen, S. Medland, A. Metspalu, K. Mohlke, J. Nielsen, Y. Okada, U. Peters, T. Polderman, D. Posthuma, A. Reiner, J. Rice, E. Rimm, R. rose, V. Runarsdottir, M. Stallings, A. Stančáková, H. Stefánsson, K. Thai, H. Tindle, Thorarinn Tyrfingsson, T. Wall, D. Weir, Constance Weisner, J. Whitfield, B. Winsvold, J. Yin, L. Zuccolo, L. Bierut, K. Hveem, James J. Lee, M. Munafo, N. Saccone, C. Willer, M. Cornelis, S. David, D. Hinds, E. Jorgenson, J. Kaprio, J. Stitzel, K. Stefánsson, T. Thorgeirsson, G. Abecasis, Dajiang J. Liu, S. Vrieze   +165 more
semanticscholar   +1 more source