Results 61 to 70 of about 8,590,328 (320)

Evaluation of the Association of Htr2a Gene Rs6313 Polymorphism with Heroin Dependence in a Sample from Northwest Iran

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2021
Introduction: Heroin dependence is a chronic relapsing disorder caused by a combination of genetic, epigenetic, and environmental factors. The genetic contribution in the vulnerability to heroin dependence is 40%-60%. Alterations in dopamine transport in
Fatemeh Mahmoudi, Leila Mehdizadeh fanid, Narges Zeinalzadeh, Mohammad ali Hosseinpour feizy   +3 more
doaj  

Systematic Review of Genetic Factors in the Etiology of Esophageal Squamous Cell Carcinoma in African Populations

Frontiers in Genetics, 2019
Background: Esophageal squamous cell carcinoma (ESCC), one of the most aggressive cancers, is endemic in Sub-Saharan Africa, constituting a major health burden.
Hannah Simba, Helena Kuivaniemi, Vittoria Lutje, Gerard Tromp, Gerard Tromp, Gerard Tromp, Gerard Tromp, Gerard Tromp, Vikash Sewram   +8 more
doaj   +1 more source

Semiparametric efficient estimation of genetic relatedness with machine learning methods [PDF]

arXiv, 2023
In this paper, we propose semiparametric efficient estimators of genetic relatedness between two traits in a model-free framework. Most existing methods require specifying certain parametric models involving the traits and genetic variants. However, the bias due to model misspecification may yield misleading statistical results.
arxiv  

Integrating molecular QTL data into genome-wide genetic association analysis: Probabilistic assessment of enrichment and colocalization

bioRxiv, 2016
We propose a novel statistical framework for integrating genetic data from molecular quantitative trait loci (QTL) mapping into genome-wide genetic association analysis of complex traits, with the primary objectives of quantitatively assessing the ...
Xiaoquan Wen, R. Pique-Regi, Francesca Luca   +2 more
semanticscholar   +1 more source

Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations

Genetics and Molecular Biology, 2017
Heparanase activity is involved in cancer growth and development in humans and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be associated with tumors.
Lixia Yu, Xiaoai Zhang, Yun Zhai, Hongxing Zhang, Wei Yue, Xiumei Zhang, Zhifu Wang, Hong Zhou, Gangqiao Zhou, Feng Gong   +9 more
doaj   +1 more source

Genetic draft, selective interference, and population genetics of rapid adaptation [PDF]

Annual Review of Ecology, Evolution, and Systematics Vol. 44: 195-215, 2013, 2013
To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare. But if positive selection operates on many loci simultaneously, as has recently been suggested for many species including ...
arxiv   +1 more source

Modeling and Testing for Joint Association Using a Genetic Random Field Model [PDF]

, 2014
Substantial progress has been made in identifying single genetic variants predisposing to common complex diseases. Nonetheless, the genetic etiology of human diseases remains largely unknown.
Adler, Ballard, Besag, Besag, Browning, Burridge, Chatterjee, Cliff, Cressie, Davies, De Iorio, Gauderman, Gotze, Laird, Manolio, Molitor, Molitor, Price, Ritchie, Romeo, Rotar, Thomas, Tzeng, Wu, Wu   +24 more
core   +2 more sources

Associations between loneliness and personality are mostly driven by a genetic association with Neuroticism.

Journal of Personality, 2018
OBJECTIVE Loneliness is an aversive response to a discrepancy between desired and actual social relationships and correlates with personality. We investigate the relationship of loneliness and personality in twin family and molecular genetic data ...
A. Abdellaoui, H. Chen, G. Willemsen, E. Ehli, G. Davies, K. Verweij, M. Nivard, E. D. de Geus, D. Boomsma, J. Cacioppo   +9 more
semanticscholar   +1 more source

Analysis of the association between rs12917707 and rs11864909 single nucleotide polymorphisms in the region of the uromoduline gene and chronic kidney disease – a family-based study

Annals of Agricultural and Environmental Medicine, 2017
Chronic kidney disease (CKD) is an important challange for healthcare systems wordwide because of its high prevalence and serious late complications.
Joanna Żywiec, Katarzyna Kiliś-Pstrusińska, Maciej Tomaszewski, Władysław Grzeszczak   +3 more
doaj   +1 more source

The Relationship Between Environmental Exposure and Genetic Architecture of the 2q33 Locus With Esophageal Cancer in South Africa

Frontiers in Genetics, 2019
Esophageal squamous cell carcinoma (ESCC) has a high prevalence in several countries in Africa and Asia. Previous genome-wide association studies (GWAS) in Chinese populations have identified several ESCC susceptibility loci, including variants on ...
Marco Matejcic, Christopher G. Mathew, Christopher G. Mathew, M. Iqbal Parker   +3 more
doaj   +1 more source