Results 61 to 70 of about 8,691,632 (395)

Epistatic Interaction Between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population With Major Depressive Disorder

Frontiers in Psychiatry, 2019
Aims: Serotonin 1A receptor (5-HT1A) and vascular endothelial growth factor (VEGF) are widely expressed in the neurons of the hippocampus and have significant roles in the pathophysiological processes of major depressive disorders (MDDs).
Dong Han, Zhengxue Qiao, Dong Qi, Jiarun Yang, Xiuxian Yang, Jingsong Ma, Lin Wang, Xuejia Song, Erying Zhao, Jian Zhang, Yanjie Yang, Xiaohui Qiu   +11 more
doaj   +1 more source

PsychArray-Based Genome Wide Association Study of Suicidal Deaths in India

Brain Sciences, 2023
Background: Suicide is a preventable but escalating global health crisis. Genome-wide association studies (GWAS) studies to date have been limited, and some are underpowered.
Chittaranjan Behera, Ruchika Kaushik, Deepak Ramkumar Bharti, Baibaswata Nayak, Daya Nand Bhardwaj, Dibyabhaba Pradhan, Harpreet Singh   +6 more
doaj   +1 more source

Analysis of MMP2 promoter polymorphisms in childhood obesity

BMC Research Notes, 2011
Background Several lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of ...
Thompson John MD, Han Dug, Morgan Angharad R, Mitchell Edwin A, Ferguson Lynnette R   +4 more
doaj   +1 more source

Network assisted analysis to reveal the genetic basis of autism

, 2015
While studies show that autism is highly heritable, the nature of the genetic basis of this disorder remains illusive. Based on the idea that highly correlated genes are functionally interrelated and more likely to affect risk, we develop a novel ...
Lei, Jing, Liu, Li, Roeder, Kathryn
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions

Frontiers in Psychiatry, 2016
Suicidal behaviors (SBs), which range from suicidal ideation to suicide attempts and completed suicide, represent a fatal dimension of mental ill-health.
Bojan Mirkovic, C. Laurent, Marc-Antoine Podlipski, T. Frebourg, D. Cohen, P. Gérardin   +5 more
semanticscholar   +1 more source

The Relationship Between Environmental Exposure and Genetic Architecture of the 2q33 Locus With Esophageal Cancer in South Africa

Frontiers in Genetics, 2019
Esophageal squamous cell carcinoma (ESCC) has a high prevalence in several countries in Africa and Asia. Previous genome-wide association studies (GWAS) in Chinese populations have identified several ESCC susceptibility loci, including variants on ...
Marco Matejcic, Christopher G. Mathew, Christopher G. Mathew, M. Iqbal Parker   +3 more
doaj   +1 more source

Association of Genetic Variation With Keratoconus [PDF]

JAMA Ophthalmology, 2020
Keratoconus is a condition in which the cornea progressively thins and protrudes in a conical shape, severely affecting refraction and vision. It is a major indication for corneal transplant. To discover new genetic loci associated with keratoconus and better understand the causative mechanism of this disease, we performed a genome-wide association ...
Jamie E Craig, Jamie E Craig, Paul N. Baird, Kent D. Taylor, Kent D. Taylor, Jerome I. Rotter, Jerome I. Rotter, Stuart MacGregor, David A. Mackey, Bennet J. McComish, Jie Jin Wang, Richard A. Mills, Kathryn P. Burdon, Kathryn P. Burdon, Srujana Sahebjada, Andrea J. Richardson, Yelena Bykhovskaya, Jac Charlesworth, Alex W. Hewitt, Colin E. Willoughby, Colin E. Willoughby, Sionne E. M. Lucas, Abi Tenen, Richard A. Jensen, Yaron S. Rabinowitz, Xiaohui Li, Xiaohui Li, Paul Mitchell   +27 more
openaire   +3 more sources

Common variants at 6p21.1 are associated with large artery atherosclerotic stroke [PDF]

, 2012
Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait.
Holliday, EG, Holliday, EG, Maguire, JM, Maguire, JM, Maguire, JM, Evans, TJ, Evans, TJ, Koblar, SA, Koblar, SA, Jannes, J, Jannes, J, Sturm, JW, Sturm, JW, Hankey, GJ, Hankey, GJ, Baker, R, Baker, R, Golledge, J, Golledge, J, Parsons, MW, Malik, R, McEvoy, M, McEvoy, M, McEvoy, M, Biros, E, Lewis, MD, Lewis, MD, Lincz, LF, Lincz, LF, Lincz, LF, Peel, R, Peel, R, Peel, R, Oldmeadow, C, Oldmeadow, C, Smith, W, Smith, W, Moscato, P, Moscato, P, Barlera, S, Bevan, S, Bis, JC, Boerwinkle, E, Boerwinkle, E, Boncoraglio, GB, Brott, TG, Brown, RD, Cheng, YC, Cole, JW, Cole, JW, Cotlarciuc, I, Devan, WJ, Devan, WJ, Devan, WJ, Fornage, M, Fornage, M, Furie, KL, Furie, KL, Grétarsdóttir, S, Gschwendtner, A, Ikram, MA, Ikram, MA, Ikram, MA, Longstreth, WT, Longstreth, WT, Longstreth, WT, Meschia, JF, Mitchell, BD, Mosley, TH, Nalls, MA, Parati, EA, Psaty, BM, Psaty, BM, Psaty, BM, Psaty, BM, Sharma, P, Stefansson, K, Stefansson, K, Thorleifsson, G, Thorsteinsdottir, U, Thorsteinsdottir, U, Traylor, M, Verhaaren, BFJ, Verhaaren, BFJ, Wiggins, KL, Worrall, BB, Sudlow, C, Sudlow, C, Rothwell, PM, Farrall, M, Farrall, M, Dichgans, M, Rosand, J, Rosand, J, Rosand, J, Markus, HS, Scott, RJ, Scott, RJ, Scott, RJ, Levi, C   +99 more
core   +1 more source