Results 91 to 100 of about 2,467,569 (240)

Meta-analysis of genetic association studies

Trends in Genetics, 2004
Meta-analysis, a statistical tool for combining results across studies, is becoming popular as a method for resolving discrepancies in genetic association studies. Persistent difficulties in obtaining robust, replicable results in genetic association studies are almost certainly because genetic effects are small, requiring studies with many thousands ...
Munafo, MR, Flint, J
openaire   +4 more sources

Clinical, genotypic, and neuropsychological profile in a series of patients with Niemann-Pick type C disease

Frontiers in Neurology
BackgroundNiemann-Pick type C (NPC) disease is a rare neurodegenerative disorder with a wide spectrum of clinical manifestations and genetic variability.
Rita dos Santos Mendes, Daniel Almeida do Valle, Daniel Almeida do Valle, Tiago dos Santos Bara, Tiago dos Santos Bara, Vanessa Furlin, Michelle da Silva Zeny, Michelle da Silva Zeny, Mara Lúcia Schmitz Ferreira Santos, Mara L. Cordeiro, Mara L. Cordeiro   +10 more
doaj   +1 more source

Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms

Frontiers in Genetics, 2019
Age-related phenotypes are characterized by genetic heterogeneity attributed to an uncertain role of evolution in establishing their molecular mechanisms.
Alexander M. Kulminski, Yury Loika, Jian Huang, Konstantin G. Arbeev, Olivia Bagley, Svetlana Ukraintseva, Anatoliy I. Yashin, Irina Culminskaya   +7 more
doaj   +1 more source

Genetic Association Study Design

, 2011
Association studies can be performed using any type of genetic polymorphism, but the one most commonly used is the single nucleotide polymorphism (SNP). This is because of its abundance across the genome, comprising 90% of all human variation. The aim of this chapter is to review various aspects of population-based study design, aimed at uncovering ...
openaire   +1 more source

Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome

Biomédica: revista del Instituto Nacional de Salud
Introduction. Multiple genetic and environmental factors interact with the development of acute coronary syndrome. Smoking is one of the environmental factors that might alter the metabolic pathways shared by genes associated with this condition ...
Liliana Franco, Natalia Gallego, Cristian Velarde, Diana Valencia, Juan Pablo Pérez-Bedoya, Kelly Betancur, Kelly Marisancen, Paola Parra, Santiago Carvalho, Luisa Parra, Evert Jiménez, Carlos Martínez, Clara Saldarriaga, Juan Carlos Arango, Nathalia González-Jaramillo, Jenny García, Ana Valencia   +16 more
doaj   +1 more source

Genetic Association Study [PDF]

, 2016
  +4 more sources

Bayesian Model Comparison in Genetic Association Analysis: Linear Mixed Modeling and SNP Set Testing [PDF]

, 2015
We consider the problems of hypothesis testing and model comparison under a flexible Bayesian linear regression model whose formulation is closely connected with the linear mixed effect model and the parametric models for SNP set analysis in genetic ...
Wen, Xiaoquan
core  

Nuevos SNP candidatos para la asociación genética con la enfermedad de Alzheimer: un análisis de desequilibrio de ligamiento para los genes FCGRIIB y PILRA

Medwave
Background Two new SNPs have been recently associated to Alzheimer’s disease in African American populations: FCGRIIB rs1050501 C/T, and PILRA rs1859788 A/G.
Alejandro Levi-Monsalve, Sergio Vladimir Flores, Germán Manriquez   +2 more
doaj   +1 more source

Genetic Association of ULK4 Gene Polymorphism (Rs1052501) With Susceptibility to Cleft Lip and Palate—A Case Control Study in South Indian Population.

, 2023
Vignesh M, A. Sumathi Felicita, Vijayashree Priyadharshini Jayaseelan   +2 more
openalex   +2 more sources

Genetically mediated associations between chronotype and neuroimaging phenotypes in the UK Biobank: a Mendelian randomisation study [PDF]

, 2023
John A. Williams, Dominic Russ, Laura Bravo-Merodio, Georgios V. Gkoutos, Mark A. Bellgrove, Andrew P. Bagshaw, Magdalena Chechlacz   +6 more
openalex   +1 more source