Results 81 to 90 of about 2,429,135 (273)

Association of Rab37 gene polymorphism and delayed menarche: a report of 2 060 women

陆军军医大学学报
Objective‍　‍To explore the association between single nucleotide polymorphism (SNP) of Rab37 gene and the age at menarche(AAM). Methods‍　‍A case-control study design was used to conduct an epidemiologic survey on 2 060 women in a community in Jurong City,
YUAN Meng, YUAN Meng, CAI Yang, CAI Yang
doaj   +1 more source

Association of polymorphic variants of PTPN22, TNF and VDR genes in children with lupus nephritis: A study in Colombian family triads

Biomédica: revista del Instituto Nacional de Salud, 2017
Introduction: Systemic lupus erythematosus is an autoimmune disease in which the severity varies according to race, sex and age of onset. This variation is also observed in the genetic markers associated with the disease, including PTPN22, VDR and TNF ...
Gloria Garavito, Eduardo Egea, Luis Fang, Clara Malagón, Carlos Olmos, Luz González, Pilar Guarnizo, Gustavo Aroca, Guillermo López, Antonio Iglesias   +9 more
doaj   +1 more source

Genome-Wide Association and Linkage Analysis of Quantitative Traits: Comparison pf Likelihood-Ratio Test and Conditional Score Statistic [PDF]

, 2009
Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype.
Dupuis, Josée, Hendricks, Audrey E, Zhu, Yanyan   +2 more
core   +1 more source

Eating disorders: from twin studies to candidate genes and beyond [PDF]

, 2005
Substantial effort has been put into the exploration of the biological background of eating disorders, through family, twin and molecular genetic studies.
Askevold F., Biederman J., Blundell J. E., Blundell J. E., Bulik C. M., Cynthia M. Bulik, Dorret I. Boomsma, Eric F. van Furth, Fichter M. M., Gorwood P., Grigoroiu-Serbanescu M., Halford J. C., Halmi K. A., Harris E. C., Herpertz-Dahlmann B., Hoek H. W., Holland A. J., Hsu L. G., Hudson J. I., Ingrid Meulenbelt, Kassett J. A., Kaye W. H., Kaye W. H., Kendler K. S., Kendler K. S., Kendler K. S., Kendler K. S., Margarita C. T. Slof-Op ‘t Landt, Meike Bartels, Nowlin N. S., P. Eline Slagboom, Ricca V., Rybakowski F., Strober M., Sullivan P. F., Sullivan P. F., Walters E. E., Walters E. E., Weltzin T. E.   +38 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Evaluation of bi-directional causal association between periodontitis and benign prostatic hyperplasia: epidemiological studies and two-sample mendelian randomization analysis

Frontiers in Genetics
Background: Periodontitis and benign prostatic hyperplasia (BPH) are all common chronic diseases with higher incidence in middle-aged and old men. Several studies have indicated a potential association between periodontitis and BPH, although the findings
Haotian Wei, Guangjie Tian, Shendan Xu, Yaqi Du, Minting Li, Yonglan Wang, Jiayin Deng, Changyi Quan   +7 more
doaj   +1 more source

Pooled Association Tests for Rare Genetic Variants: A Review and Some New Results

, 2014
In the search for genetic factors that are associated with complex heritable human traits, considerable attention is now being focused on rare variants that individually have small effects.
Derkach, Andriy, Lawless, Jerry F., Sun, Lei   +2 more
core   +1 more source

Disease‐Concordant Twins Empower Genetic Association Studies [PDF]

Annals of Human Genetics, 2016
SummaryGenome‐wide association studies with moderate sample sizes are underpowered, especially when testing SNP alleles with low allele counts, a situation that may lead to high frequency of false‐positive results and lack of replication in independent studies.
Tan, Qihua, Li, Weilong, VANDIN, FABIO
openaire   +4 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source