Results 91 to 100 of about 2,685,260 (259)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Breeding for durable riding horses using competition statistics [PDF]
, 2011 The breeding objectives for Swedish Warmblood horses are aiming for producing horses that have a good conformation and are internationally competitive in dressage and show jumping. It also states that the horses should be durable.
Braam, Åsa
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EVALUATION OF TOMATO PROMISING HYBRIDS PRODUCTIVITY UNDER DIFFERENT ENVIRONMENTAL CONDITIONS [PDF]
Egyptian Journal of Desert ResearchThe impact of successive climate changes has become a phenomenon that requires continuous evaluation and selection of suitable genotypes in terms of quality and productivity for most crops around the world, and this is one of the objectives of plant ...
Khaled Bayomi +5 more
doaj +1 more source
Plant genetic resources for agriculture, plant breeding, and biotechnology: Experiences from Cameroon, Kenya, the Philippines, and Venezuela [PDF]
"Local farming communities throughout the world face binding productivity constraints, diverse nutritional needs, environmental concerns, and significant economic and financial pressures.
Cohen, Joel I. +7 more
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Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
BMC Genomics, 2019 Background Sugarcane smut is a fungal disease caused by Sporisorium scitamineum. Cultivation of smut-resistant sugarcane varieties is the most effective way to control this disease. The interaction between sugarcane and S.
Yachun Su +9 more
doaj +1 more source
Breeding for trypanotolerance in African cattle [PDF]
, 2001 Trypanosomosis, or sleeping sickness, is one of the most important livestock diseases in Africa. Some West African cattle breeds show a degree of resistance to a trypanosome infection: they are trypanotolerant.
Waaij, E.H., van der
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Animal breeding in organic farming [PDF]
, 2001 After a general introduction into the available breeding techniques for animal breeding and an overview of the organic principles, points for discussion are identified and scenario's for organically accepted breeding methods are ...
Nauta, W.J. +4 more
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