Results 171 to 180 of about 431,685 (314)

Revealing the inherent design principles of the genetic code via an error correcting code representation. [PDF]

Sci Rep
Aharon A, Polak P, Yaari G.
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The Genetic Code*

, 2015
openaire   +2 more sources

<i>Chlamydomonas</i> chloroplast genes tolerate compression of the genetic code to just 51 codons. [PDF]

Proc Natl Acad Sci U S A
Mordaka PM, Clouston K, Cui J, Holzer A, Jackson HO, Purton S, Smith AG.   +6 more
europepmc   +1 more source

Analogies of Genetic and Chemical Code

, 2017
Starting from the previously established hypothesis on the existence of the coherence of the chemical and genetic code, new facts and new insights on the existence of essential analogies between the genetic and chemical code are presented, whereby the ...
Miloje M. Rakočević
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

StayRose: A photostable StayGold derivative redshifted by genetic code expansion. [PDF]

J Biol Chem
Scott W, Ivorra-Molla E, Akhuli D, Massam-Wu T, Lysyganicz PK, Walsh R, Parent M, Cook J, Song L, Kumar A, Schneider F, Mishima M, Crow A, Balasubramanian MK.   +13 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Universality in the Genetic Code [PDF]

Science, 1964
openaire   +2 more sources

Covalent capture and genetic code expansion enables chemoproteomic profiling and functional characterization of lysine acetoacetylation. [PDF]

Sci Adv
Song X, Lu Y, Guo X, Zheng Y, Huang H.
europepmc   +1 more source