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Genetics and the Origin of the Genetic Code

Origins of Life, 1974
The genetic code has been analysed by a method similar to that used by Gregor Mendel. The current codon catalogue is shown to be symmetrically subdivisible into two discrete subcatalogues of eight quartets each by classifying the quartets as monocoding (for one amino acid only) vs heterocoding (for two amino acids or for amino acid plus nonsense).
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Phylogeny of genetic codes and punctuation codes within genetic codes

Biosystems, 2015
Punctuation codons (starts, stops) delimit genes, reflect translation apparatus properties. Most codon reassignments involve punctuation. Here two complementary approaches classify natural genetic codes: (A) properties of amino acids assigned to codons (classical phylogeny), coding stops as X (A1, antitermination/suppressor tRNAs insert unknown ...
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On the Origin of the Genetic Code

Journal of Theoretical Biology, 1992
The main theories which have been suggested to explain the origin of genetic code organization are discussed. The coevolution theory, which considers the genetic code as a map of the biosynthetic relationships between amino acids, seems to be based on a mechanism that links it closely to certain stages of the origin of metabolism, which makes it ...
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Rewriting the genetic code

Science, 2021
Making room in the genetic code allows the creation of designer proteins with new building ...
Delilah, Jewel, Abhishek, Chatterjee
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Stereospecificity of the genetic code

Journal of Molecular Evolution, 1974
A sterical correlation of the amino acids to their anticodon nucleotides is given. The main principle is the intercalation of the amino acid and the binding of the aliphatic amino acid hydrogen atoms through hydrogen bonds to the π-electrons of the bases.
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The path to the genetic code

Biochimica et Biophysica Acta (BBA) - General Subjects, 2017
In December of 1966 the last nucleotide triplet in the genetic code has been assigned (Brenner et al., 1967 [1]) thus completing years of studies aimed at deciphering the nature of the relationship between the sequences of genes and proteins. The end product, the table of the genetic code, was a crowning achievement of the quest to unravel the basic ...
Maciej, Szymanski, Jan, Barciszewski
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The genetic code and cyclic codes.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1983
We proposed previously a cyclic code made of 22 triplets, which we now call the AB code. It is made up of the following chain: AUGGUGCCAUUCAAGACUAUGA. The letters A, U, C, G represent the classical symbols of the (purine and pyrimidine) bases of the genetic code.
J, Demongeot, J, Besson
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Genetics: Clues in the code

Nature, 2016
Gene exploration is providing unexpected insights into inflammatory bowel disease, and getting scientists closer to finding treatments that target the biological mechanisms.
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Collinearity and the genetic code

Proceedings of the Royal Society of London. Series B. Biological Sciences, 1966
Abstract Modern knowledge of the mechanism of expression of genes derives from the idea, formulated by Beadle in 1945, that each gene determines the structure of a specific protein At that time, this was all that could be said since very little was known about the chemical structure of genes and proteins and nothing about their ...
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The evolution of the genetic code

Biochimie, 1976
Summary A Model is described for the evolution of proteins within organisms in the primitive environment. The model is then used to show which chemical and biological properties of the amino acids could have been important in the evolution of the genetic code.
R P, Jorré, R N, Curnow
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