Results 231 to 240 of about 434,115 (269)
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Annual Review of Biophysics and Biomolecular Structure, 2006
Recently, a general method was developed that makes it possible to genetically encode unnatural amino acids with diverse physical, chemical, or biological properties in Escherichia coli, yeast, and mammalian cells. More than 30 unnatural amino acids have been incorporated into proteins with high fidelity and efficiency by means of a unique codon and ...
Lei, Wang +2 more
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Recently, a general method was developed that makes it possible to genetically encode unnatural amino acids with diverse physical, chemical, or biological properties in Escherichia coli, yeast, and mammalian cells. More than 30 unnatural amino acids have been incorporated into proteins with high fidelity and efficiency by means of a unique codon and ...
Lei, Wang +2 more
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Optimization and the genetic code
Origins of life and evolution of the biosphere, 1989The present paper will focus on the relation between the structure of the table of the genetic code and the evolution of primitive organisms: it will be shown that the organization of the code table according to an optimization principle based on the notion of resistance to errors can provide a criterium for selection. The ordered aspect of the genetic
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2017
Protein design is usually limited to 20 amino acids. Since the chemical abilities of these amino acids are limited, a lot of interesting functions are not applicable in protein design. We aim to enable the translational incorporation of non-canonical amino acids (ncAAs) through an expanded genetic code.
Karsten, Lennard +18 more
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Protein design is usually limited to 20 amino acids. Since the chemical abilities of these amino acids are limited, a lot of interesting functions are not applicable in protein design. We aim to enable the translational incorporation of non-canonical amino acids (ncAAs) through an expanded genetic code.
Karsten, Lennard +18 more
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The genetic code is not universal
BioSystemsRecently, a new genetic code with 62 sense codons, coding for 21 amino acids, and only 2 termination codons has been identified in archaea. The authors argue that the appearance of this variant of the genetic code is due to the relatively recent and complete recoding of all UAG stop codons to codons encoding for pyrrolysine.
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Scientific American, 1963
This article describes how combinations of bases, or code letters, provide the information used by cells to construct proteins from twenty common kinds of amino acids. Nirenberg recounts recent developments in the field of genetics and illustrates the components and structure of DNA and RNA, and the process of protein synthesis.
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This article describes how combinations of bases, or code letters, provide the information used by cells to construct proteins from twenty common kinds of amino acids. Nirenberg recounts recent developments in the field of genetics and illustrates the components and structure of DNA and RNA, and the process of protein synthesis.
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The origin of the genetic code
Biochemical and Biophysical Research Communications, 1970Abstract The codons of the genetic code would be expected to participate in the adsorption sites selecting amino acids for reaction with tRNA. A codon-anticodon site shows good correlation with corresponding amino acid structures. It seems therefore probable that the genetic code originated in an evolutionary replacement of a part of an amino acid ...
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ON THE ORIGIN OF THE GENETIC CODE
Canadian Journal of Genetics and Cytology, 1970A detailed re-examination of the codon and the anticodon catalogues has led to the conclusion that the initiation of codons and anticodons was a coincident process with a significant doublet phase, and that a double-stranded polynucleotide was an essential feature.
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Engineering of the genetic code
Current Opinion in BiotechnologyThe genetic code is a universally conserved mechanism that translates genetic information into proteins, consisting of 64 codons formed by four nucleotide bases. With a few exceptions, the genetic code universally encodes 20 canonical amino acids (AAs) and three stop signals, with many AAs represented by multiple codons.
Yael Cohen, Lital Alfonta
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The origin of the genetic code
Journal of Molecular Biology, 1968Abstract The general features of the genetic code are described. It is considered that originally only a few amino acids were coded, but that most of the possible codons were fairly soon brought into use. In subsequent steps additional amino acids were substituted when they were able to confer a selective advantage, until eventually the code became ...
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The Science of Nature, 1973
The origin of the genetic code is not merely an evolutionary juggling of codon assignments until some optimal configuration is achieved. It is, rather, the more interesting and profound problem of how codon assignments arose. This is part and parcel of the origin of a translating mechanism.
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The origin of the genetic code is not merely an evolutionary juggling of codon assignments until some optimal configuration is achieved. It is, rather, the more interesting and profound problem of how codon assignments arose. This is part and parcel of the origin of a translating mechanism.
openaire +2 more sources