Results 31 to 40 of about 5,981,041 (371)
Proceedings of the Japan Academy, Series B, 2008 In 1985, we reported that a bacterium, Mycoplasma capricolum, used a deviant genetic code, namely UGA, a "universal" stop codon, was read as tryptophan. This finding, together with the deviant nuclear genetic codes in not a few organisms and a number of mitochondria, shows that the genetic code is not universal, and is in a state of evolution.
OHAMA, Takeshi +3 more
openaire +3 more sources
The Genetic Code as a Periodic Table: Algebraic Aspects [PDF]
, 2000 The systematics of indices of physico-chemical properties of codons and amino acids across the genetic code are examined. Using a simple numerical labelling scheme for nucleic acid bases, data can be fitted as low-order polynomials of the 6 coordinates ...
Bashford +30 more
core +3 more sources
Expanding the limits of the second genetic code with ribozymes
Nature Communications, 2019 The site-specific incorporation of noncanonical monomers into polypeptides through genetic code reprogramming permits synthesis of bio-based products that extend beyond natural limits.
Joongoo Lee +12 more
semanticscholar +1 more source
Reprogramming the Genetic Code [PDF]
Science, 2011 Incorporating unnatural amino acids into proteins presents challenges in expanding the genetic code.
openaire +2 more sources
Decoder-in-the-Loop: Genetic Optimization-based LDPC Code Design [PDF]
, 2019 LDPC code design tools typically rely on asymptotic code behavior and are affected by an unavoidable performance degradation due to model imperfections in the short length regime.
Brink, Stephan ten +4 more
core +3 more sources
eLife, 2018 D-aminoacyl-tRNA deacylase (DTD) acts on achiral glycine, in addition to D-amino acids, attached to tRNA. We have recently shown that this activity enables DTD to clear non-cognate Gly-tRNAAla with 1000-fold higher efficiency than its activity on Gly ...
Santosh Kumar Kuncha +7 more
doaj +1 more source
Breaking the genetic code – a new revolutionary stage in the development of molecular biology: 1968 Nobel Prize laureates M. W. Nirenberg, H. G. Khorana, R. W. Holley [PDF]
The Ukrainian Biochemical Journal, 2021 This review presents the life stories of M. Nirenberg, H. Khorana, and R. Holley, winners of the 1968 Nobel Prize in Physiology or Medicine, the history of the discoveries made by these scientists, and the methodological approaches used in their works ...
O. P. Matyshevska +2 more
doaj +1 more source
Genetic code 1990. Outlook [PDF]
Experientia, 1990 The genetic code is evolving as shown by 9 departures from the universal code: 6 of them are in mitochondria and 3 are in nuclear codes. We propose that these changes are preceded by disappearance of a codon from coding sequences in mRNA of an organism or organelle. The function of the codon that disappears is taken by other, synonymous codons, so that
openaire +2 more sources
Evolutionary instability of CUG-Leu in the genetic code of budding yeasts
Nature Communications, 2018 The genetic code used in nuclear genes is almost universal, but here we report that it changed three times in parallel during the evolution of budding yeasts.
semanticscholar +1 more source
Site-specific incorporation of phosphotyrosine using an expanded genetic code. [PDF]
, 2017 Access to phosphoproteins with stoichiometric and site-specific phosphorylation status is key to understanding the role of protein phosphorylation.
Allison Wong +36 more
core +1 more source