Results 31 to 40 of about 5,849,979 (303)
eLife, 2018 D-aminoacyl-tRNA deacylase (DTD) acts on achiral glycine, in addition to D-amino acids, attached to tRNA. We have recently shown that this activity enables DTD to clear non-cognate Gly-tRNAAla with 1000-fold higher efficiency than its activity on Gly ...
Santosh Kumar Kuncha +7 more
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Genetic code 1990. Outlook [PDF]
Experientia, 1990 The genetic code is evolving as shown by 9 departures from the universal code: 6 of them are in mitochondria and 3 are in nuclear codes. We propose that these changes are preceded by disappearance of a codon from coding sequences in mRNA of an organism or organelle. The function of the codon that disappears is taken by other, synonymous codons, so that
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On the origin of degeneracy in the genetic code
Interface Focus, 2019 The degeneracy of amino acid coding is one of the most crucial and enigmatic aspects of the genetic code. Different theories about the origin of the genetic code have been developed. However, to date, there is no comprehensive hypothesis on the mechanism
D. González, S. Giannerini, R. Rosa
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eLife, 2018 Organisms possessing genetic codes with unassigned codons raise the question of how cellular machinery resolves such codons and how this could impact horizontal gene transfer.
Natalie Jing Ma +4 more
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Smart port city of Odessa: brilliant embodiment of Vitruvius` theories of beauty
Vitruvio: International Journal of Architectural Technology and Sustainability, 2016 The condition of successivedevelopment, sustainability of the whole is a continuous relation between the present, the past and the future. An interdisciplinary approach aimed to create the holistic picture of the world helps to get an objective ...
Andrey Dobrolubsky +2 more
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Origins and Early Evolution of the tRNA Molecule
Life, 2015 Modern transfer RNAs (tRNAs) are composed of ~76 nucleotides and play an important role as “adaptor” molecules that mediate the translation of information from messenger RNAs (mRNAs). Many studies suggest that the contemporary full-length tRNA was formed
Koji Tamura
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Genetic Code Expansion Approaches to Decipher the Ubiquitin Code. [PDF]
Chem RevWanka V, Fottner M, Cigler M, Lang K.
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Upgrading aminoacyl-tRNA synthetases for genetic code expansion.
Current Opinion in Chemical Biology, 2018 Synthesis of proteins with non-canonical amino acids via genetic code expansion is at the forefront of synthetic biology. Progress in this field has enabled site-specific incorporation of over 200 chemically and structurally diverse amino acids into ...
O. Vargas-Rodriguez +3 more
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Genetic Code Expansion in Animals.
ACS Chemical Biology, 2018 Expanding the genetic code to enable the incorporation of unnatural amino acids into proteins in biological systems provides a powerful tool for studying protein structure and function.
Wes Brown, Jihe Liu, A. Deiters
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Multi-objective genetic algorithms in the study of the genetic code's adaptability
Information Sciences, 2018 Using a robustness measure based on values of the polar requirement of amino acids, Freeland and Hurst (1998) showed that less than one in one million random hypothetical codes are better than the standard genetic code.
Lariza Laura de Oliveira +2 more
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