Results 11 to 20 of about 431,685 (314)

Graphical representation of genetic code algebra [PDF]

Network Biology, 2023
During the translation process, the genetic code is the nucleotide sequence that determines the amino acid sequence of protein molecules. A codon is a universal triplet of nucleotides that codes for an amino acid. A group G's identity graph is a graph in
Birinchi Kumar Boruah, Tazid Ali
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The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation

Cell Reports, 2023
Summary: Melanin is a pigment produced from the amino acid L-tyrosine in melanosomes. The CNC-family transcription factor Nrf3 is expressed in the basal layer of the epidermis, where melanocytes reside, but its melanogenic function is unclear.
Tsuyoshi Waku, Sota Nakada, Haruka Masuda, Haruna Sumi, Ayaka Wada, Shuuhei Hirose, Iori Aketa, Akira Kobayashi   +7 more
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NRF3 activates mTORC1 arginine-dependently for cancer cell viability

iScience, 2023
Summary: Cancer cells coordinate the mTORC1 signals and the related metabolic pathways to robustly and rapidly grow in response to nutrient conditions. Although a CNC-family transcription factor NRF3 promotes cancer development, the biological relevance ...
Shuuhei Hirose, Tsuyoshi Waku, Misato Tani, Haruka Masuda, Keiko Endo, Sanae Ashitani, Iori Aketa, Hina Kitano, Sota Nakada, Ayaka Wada, Atsushi Hatanaka, Tsuyoshi Osawa, Tomoyoshi Soga, Akira Kobayashi   +13 more
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The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis

Scientific Reports, 2023
The ubiquitin‒proteasome system (UPS) and autophagy are the two primary cellular pathways of misfolded or damaged protein degradation that maintain cellular proteostasis.
Atsushi Hatanaka, Sota Nakada, Gen Matsumoto, Katsuya Satoh, Iori Aketa, Akira Watanabe, Tomoaki Hirakawa, Tadayuki Tsujita, Tsuyoshi Waku, Akira Kobayashi   +9 more
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NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition

iScience, 2021
Summary: Lipids, such as cholesterol and fatty acids, influence cell signaling, energy storage, and membrane formation. Cholesterol is biosynthesized through the mevalonate pathway, and aberrant metabolism causes metabolic diseases.
Tsuyoshi Waku, Toru Hagiwara, Natsuko Tamura, Yuri Atsumi, Yasuomi Urano, Mikiko Suzuki, Takuya Iwami, Katsuya Sato, Masayuki Yamamoto, Noriko Noguchi, Akira Kobayashi   +10 more
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Recombinant Lactococcus lactis Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model

Journal of Diabetes Research, 2021
Type 1 diabetes (T1D) is an autoimmune disease that culminates in beta cell destruction in the pancreas and, subsequently, deficiency in insulin production.
Tatiane M. Preisser, Vanessa P. da Cunha, Mariana P. Santana, Vanessa B. Pereira, Denise C. Cara, Bianca M. Souza, Anderson Miyoshi   +6 more
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Indirect Routes to Aminoacyl-tRNA: The Diversity of Prokaryotic Cysteine Encoding Systems

Frontiers in Genetics, 2022
Universally present aminoacyl-tRNA synthetases (aaRSs) stringently recognize their cognate tRNAs and acylate them with one of the proteinogenic amino acids.
Takahito Mukai, Takahito Mukai, Kazuaki Amikura, Xian Fu, Dieter Söll, Dieter Söll, Ana Crnković, Ana Crnković   +7 more
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An Amino Acid-Swapped Genetic Code [PDF]

, 2020
Preventing the escape of hazardous genes from genetically modified organisms (GMOs) into the environment is one of the most important issues in biotechnology research.
Tozaki, Masahiro, Murakami, Hiroshi, Fujino, Tomoshige   +2 more
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A computational screen for alternative genetic codes in over 250,000 genomes

eLife, 2021
The genetic code has been proposed to be a ‘frozen accident,’ but the discovery of alternative genetic codes over the past four decades has shown that it can evolve to some degree.
Yekaterina Shulgina, Sean R Eddy
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Cracking the genetic code with neural networks [PDF]

, 2023
peer reviewedThe genetic code is textbook scientific knowledge that was soundly established without resorting to Artificial Intelligence (AI). The goal of our study was to check whether a neural network could re-discover, on its own, the mapping links ...
Louppe, Gilles, Leclercq, Marine, Joiret, Marc, Lambrechts, Gaspard, Geris, Liesbet, Rapino, Francesca, Close, Pierre   +6 more
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