Results 41 to 50 of about 2,389 (119)
On the origin of the genetic code
Genes & Genetic Systems, 2023 Mechanisms underlying how the genetic code was generated by Darwinian selection have remained elusive since the code was cracked in 1965. Here, I propose a hypothesis on the emergence of the genetic code and predict that its emergence was driven by sequential distinct selective pressures.
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Bioinformatic Analysis Reveals Archaeal tRNATyr and tRNATrp Identities in Bacteria
Life, 2017 The tRNA identity elements for some amino acids are distinct between the bacterial and archaeal domains. Searching in recent genomic and metagenomic sequence data, we found some candidate phyla radiation (CPR) bacteria with archaeal tRNA identity for Tyr-
Takahito Mukai +3 more
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Efforts and Challenges in Engineering the Genetic Code
Life, 2017 This year marks the 48th anniversary of Francis Crick’s seminal work on the origin of the genetic code, in which he first proposed the “frozen accident” hypothesis to describe evolutionary selection against changes to the genetic code that cause ...
Xiao Lin +2 more
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Molecular Mechanisms and the Significance of Synonymous Mutations
BiomoleculesSynonymous mutations result from the degeneracy of the genetic code. Most amino acids are encoded by two or more codons, and mutations that change a codon to another synonymous codon do not change the amino acid in the gene product.
Peter Oelschlaeger
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The genetic code as an operational a priori: xenobiology and the rewriting of life’s grammar
Frontiers in Synthetic BiologyThis study refines Konrad Lorenz’s concept of “natural transcendentalism” by drawing a fundamental distinction between the genetic code and the genome, and by exploring the philosophical consequences of that distinction. I argue that the genetic code can
Nediljko Budisa
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Logic in the Light of Cognitive Science
Studies in Logic, Grammar and Rhetoric, 2016 Logical theory codifies rules of correct inferences. On the other hand, logical reasoning is typically considered as one of the most fundamental cognitive activities.
Woleński Jan
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The Platonic Receptacle (Hypodoché), Whitehead’s Philosophy, and Genome Evolution
Viruses, 2017 The discovery of a universal genetic code utilized by all existing organisms became the backbone of biology. The coding capacity underwent changes during evolution, but its main fluctuation results from its different reading and regulation.
Jan Svoboda, Jan Svoboda
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1996 No Abstract.
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Augmenting tomato functional genomics with a genome-wide induced genetic variation resource
Frontiers in Plant ScienceInduced mutations accelerate crop improvement by providing novel disease resistance and yield alleles. However, the alleles with no perceptible phenotype but have an altered function remain hidden in mutagenized plants.
Prateek Gupta +6 more
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