Results 131 to 140 of about 4,570,239 (335)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Next‐generation metrics for monitoring genetic erosion within populations of conservation concern
Evolutionary Applications, 2017 Genetic erosion is a major threat to biodiversity because it can reduce fitness and ultimately contribute to the extinction of populations. Here, we explore the use of quantitative metrics to detect and monitor genetic erosion.
G. Leroy +6 more
semanticscholar +1 more source
Determinants of cereal diversity in communities and on household farms of the Northern Ethiopian Highlands: [PDF]
"On farm conservation of crop diversity poses obvious policy challenges in terms of the design of appropriate incentive mechanisms and possible trade-offs between conservation and productivity.
Benin, Samuel +4 more
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Biological Conservation, 2018 Gene conservation programs help safeguard species and tangibly benefit ecological restoration, agriculture, forestry, and horticulture. Here we describe a new method for deciding which and how many populations and individuals to conserve ex situ, and we ...
S. Hoban, S. Kallow, C. Trivedi
semanticscholar +1 more source
Consultation on fish genetic resources [PDF]
Naturally occurring fish genetic resources are of great importance for fisheries and aquaculture. Fish farmers and fishers face a future in which the diversity of their basic resources is under threat and the genetic composition of these resources will ...
Casal, C.M.V. (eds.), Pullin, R.S.V.
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
No evidence for a recent genetic bottleneck in the endangered Sheko cattle breed (African Bos taurus) revealed by microsatellite analysis [PDF]
, 2009 Sheko is African taurine cattle, valued for its milk yield, adaptation to humid tsetse infested environment and trypanotolerance. We used 30 microsatellite markers in analyzing 30 DNA samples. We found high genetic diversity and no genetic bottlenecks in
Hailu Dadi +6 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Genetics and Molecular Biology, 2004 In this study, the RAPD technique was used to analyze the genetic structure of populations of the fish Astyanax altiparanae (Characidae, Tetragonopterinae) living in the lower, middle and upper Paranapanema River, Brazil.
Maria Sueli Papa Leuzzi +3 more
doaj +1 more source