Results 41 to 50 of about 974,406 (246)

Causal associations of obesity related anthropometric indicators and body compositions with knee and hip arthritis: A large-scale genetic correlation study

Frontiers in Endocrinology, 2022
BackgroundsEpidemiological studies have repeatedly investigated the association between obesity related anthropometric indicators and body compositions and osteoarthritis (OA). However, the results have remained inconsistent.
Chao Wang, Yong Zhu, Zhi Liu, Haitao Long, Zhe Ruan, Shushan Zhao, Shushan Zhao   +6 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Estimation of Genetic Parameters for Feeding Pattern Traits and Its Relationship to Feed Efficiency and Production Traits in Duroc Pigs

Agriculture, 2021
This study was conducted to estimate the genetic parameters of different feeding pattern traits, including average daily feed intake (ADFI), average occupation time per day (AOTD), average occupation time per visit (AOTV), average daily feeding rate ...
Kier G. Santiago, Sung-Hoon Kim, Bryan Irvine Lopez, Dong-Hui Lee, Young-Gyu Cho, Yu-Na Song, Kang-Seok Seo   +6 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Efeitos genéticos e de ambiente sobre a produção de leite e a contagem de células somáticas em vacas holandesas Genetic and environmental effects on milk yield and somatic cell count of Holstein cows

Revista Brasileira de Zootecnia, 2007
Visando estudar as associações genéticas e fenotípicas entre a contagem de células somáticas (CCS) e a produção de leite até 305 dias (P305) e avaliar as perspectivas de utilização da CCS como critério de seleção em bovinos leiteiros, utilizaram-se dados
Luana Martins de Andrade, Lenira El Faro, Vera Lucia Cardoso, Lucia Galvão de Albuquerque, Laerte Dagher Cassoli, Paulo Fernando Machado   +5 more
doaj   +1 more source

Transethnic genetic correlation estimates from summary statistics [PDF]

The American Journal of Human Genetics, 2016
abstractThe increasing number of genetic association studies conducted in multiple populations provides unprecedented opportunity to study how the genetic architecture of complex phenotypes varies between populations, a problem important for both medical and population genetics. Here we develop a method for estimating thetransethnic genetic correlation:
Brown, Brielin C, Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes, Ye, Chun Jimmie, Price, Alkes L, Zaitlen, Noah   +4 more
openaire   +4 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Detecting Local Genetic Correlations with Scan Statistics [PDF]

Nature Communications, 2019
AbstractGenetic correlation analysis has quickly gained popularity in the past few years and provided insights into the genetic etiology of numerous complex diseases. However, existing approaches oversimplify the shared genetic architecture between different phenotypes and cannot effectively identify precise genetic regions contributing to the genetic ...
Guo, Hanmin, Li, James J., Lu, Qiongshi, Hou, Lin   +3 more
openaire   +3 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Avaliação e seleção precoce para crescimento de Pinus taeda Early evaluation and selection for growth in Pinus taeda

Pesquisa Agropecuária Brasileira, 2002
O objetivo deste trabalho foi avaliar a eficiência de diferentes métodos de seleção quanto aos caracteres ligados ao crescimento do fuste e o potencial da seleção precoce de genitores.
Estefano Paludzyszyn Filho, José Sebastião Cunha Fernandes, Marcos Deon Vilela de Resende   +2 more
doaj   +1 more source