Results 61 to 70 of about 1,122,121 (342)

Estimating trans-ancestry genetic correlation with unbalanced data resources [PDF]

arXiv, 2022
The aim of this paper is to propose a novel estimation method of using genetic-predicted observations to estimate trans-ancestry genetic correlations, which describes how genetic architecture of complex traits varies among populations, in genome-wide association studies (GWAS). Our new estimator corrects for prediction errors caused by high-dimensional
arxiv  

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization [PDF]

arXiv, 2021
When genetic variants in a gene cluster are associated with a disease outcome, the causal pathway from the variants to the outcome can be difficult to disentangle. For example, the chemokine receptor gene cluster contains genetic variants associated with various cytokines.
arxiv  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Efeito da interação reprodutor x rebanho sobre as produções de leite e de gordura na raça Pardo-Suíça Effects of sire x herd interaction on milk and fat yields in Brown-Swiss herds

Revista Brasileira de Zootecnia, 2005
Dados de 4.959 lactações de 2.414 vacas da raça Pardo-Suíça, filhas de 70 reprodutores, distribuídos em 51 rebanhos, foram utilizados para se estimar o componente de variância para a interação reprodutor x rebanho das produções de leite e de gordura e ...
Mirella Leme Franco Geraldini Sirol, Ricardo Frederico Euclydes, Robledo de Almeida Torres, Paulo Sávio Lopes, Carmen Silva Pereira, Cláudio Vieira Araújo, Francisco Palma Rennó   +6 more
doaj   +1 more source

On the nature of intraspecific genetic variability: Evidence against the ruling paradigm [PDF]

arXiv, 2011
Empirical evidence is presented which contradicts the established interpretation of the intraspecific genetic variability as the adaptive potential of the species: the uniform evolutionary tempo across the life kingdom, species discreteness, and absence of correlation between genetic variability and prosperity of extant species testify against the ...
arxiv  

Symmetry and Codon Usage Correlations in the Genetic Code [PDF]

, 1998
The ratios of the codon usage in the quartets and sextets for the vertebrate series exhibit a correlated behaviour which fits naturally in the framework of the crystal basis model of the genetic code. Moreover the observed universal behaviour of these suitably normalized ratios can be easily explained.
arxiv   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

The genetic architecture of lipoprotein subclasses in Gullah-speaking African American families enriched for type 2 diabetes: The Sea Islands Genetic African American Registry (Project SuGAR)

Journal of Lipid Research, 2010
We sought to partition the genetic and environmental influences on lipoprotein subclasses and identify genomic regions that may harbor genetic variants that influence serum lipoprotein levels in a sample of Gullah-speaking African-Americans. We genotyped
Jasmin Divers, Michèle M. Sale, Lingyi Lu, Wei-Min Chen, Kerry H. Lok, Ida J. Spruill, Jyotika K. Fernandes, Carl D. Langefeld, W. Timothy Garvey   +8 more
doaj  

Parâmetros genéticos do peso no início da estação de monta, considerado indicativo do peso adulto de matrizes Nelore Genetic parameters for weight at the beginning of breeding season, considered indicative of mature weight of Nelore cows

Revista Brasileira de Zootecnia, 2004
Parâmetros genéticos foram estimados para peso na entrada da monta (PEM), considerado como indicativo do peso adulto de vacas Nelore. O arquivo de dados continha 7.902 registros de 1.556 vacas pertencentes a um experimento de seleção conduzido na Estação
Maria Eugênia Zerlotti Mercadante, Alexander George Razook, José Benedito de Freitas Trovo, Joslaine Noely dos Santos Gonçalves Cyrillo, Leopoldo Andrade de Figueiredo   +4 more
doaj   +1 more source