Results 61 to 70 of about 974,406 (246)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Genetic overlap between major depressive disorder and obstructive sleep apnea
Frontiers in PsychiatryObjectiveObservational studies have frequently shown a co-occurrence of psychiatric disorders and Obstructive sleep apnea (OSA), with major depressive disorder (MDD) being a prevalent psychiatric disorder.
Fangbo Lin +4 more
doaj +1 more source
Genetic correlations between longevity and conformation traits in the Czech Holstein population
Czech Journal of Animal Science, 2012 Genetic correlations between longevity and conformation traits were estimated using data on Czech Holstein cows first calved in the years 1993-2008. Longevity traits considered were length of productive life and number of lactations initiated and their ...
L. Zavadilová, M. Štípková
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Journal of Dairy Science: Genetic selection to reduce CH4 emissions is a promising solution for reducing the environmental impact of dairy cattle production. Before such a selection program can be implemented, however, it is necessary to have a better understanding of the ...
S. Fresco +3 more
doaj +1 more source
Czech Journal of Animal Science, 2013 Genetic parameters for total number of piglets born per litter, number of piglets weaned per litter, lean meat content, and average daily gain from birth till the end of the field test were estimated for Czech Large White (445 589 records) and Czech ...
E. Krupa, J. Wolf
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Diallel crossing in Pinus cembra : IV. Age trends in genetic parameters and genetic gain for growth and branching traits [PDF]
Annals of Forest Research, 2008 This paper reports results from a complete 10 x 10 diallel carried out in a natural population of Swiss stone pine (Pinus cembra L.) from the southern Carpathian Mountains.
Ioan Blada, Flaviu Popescu
doaj
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Frontiers in EndocrinologyObjectivesTo investigate the causal relationship between type 2 diabetes mellitus (T2DM, exposure) and isolated REM sleep behavior disorder (iRBD, outcome).MethodsGenome-wide association study (GWAS) data for iRBD comprised 9,447 samples, including 1,061
Ru-Yu Zhang +7 more
doaj +1 more source