Results 121 to 130 of about 4,213,652 (301)

Loss of information in genetic distances [PDF]

Nature, 1988
M A, Steel, M D, Hendy, D, Penny
openaire   +2 more sources

Mantel tests between the genetic distance and the geographical parameters.

, 2013
(a) Mantel test between Nei’s genetic distance and the geographical distance among populations. (b) Mantel test between Nei’s genetic distance and the latitudinal distance. (c) Mantel test between Nei’s genetic distance and the longitudinal distance.
Mengran Zhao (496324), Chenyang Huang (496325), Jinxia Zhang (496327), Jibin Qu (496326), Qiang Chen (114038), Xiangli Wu (207701)   +5 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Genetic distance metrices used for PCoA

, 2016
Genetic distance metrices used for ...
Juha Merilä (192116), Zitong Li (3245613), Guo, Baocheng, Li, Zitong, Merilä, Juha, Baocheng Guo (3245610)   +5 more
core   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Whole-Genome Sequencing Reveals the Progress of Genetic Breeding in Eriocheir sinensis

Animals
Eriocheir sinensis is an important and popular crustacean species in China, producing huge economic benefits. Large individuals of E. sinensis are preferred due to market demand.
Xuanpeng Wang, Gaowei Zhang, Dandan Gao, Yongchun Ge, Yongxu Cheng, Xinhai Wang   +5 more
doaj   +1 more source

Genetic distance informs polygenic score predictive accuracy. [PDF]

Trends Genet, 2023
Wojcik GL.
europepmc   +1 more source

Association between genetic dissimilarity and geographic distance.

, 2015
(A) Genetic dissimilarity and geographic distance between pairs of C580Y mutants (A) and wild type parasites (B). Genetic dissimilarity of flanking microsatellites for C580Y is highly associated with geographic distance (Pearson's correlation coefficient:
Kanungnit Congpuong (717005), Venkatachalam Udhayakumar (48734), Patrick S. Kachur (679170), Sheila Akinyi Okoth (717004), Mateusz M. Plucinski (3186117), Ira F. Goldman (717007), John W. Barnwell (185405), Wichai Satimai (717008), Eldin Talundzic (184351), Chansuda Wongsrichanalai (80271), Lindsay Morton (717006)   +10 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source