Results 131 to 140 of about 1,273,508 (343)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Ancient fossil specimens of extinct species are genetically more distant to an outgroup than extant sister species are [PDF]

, 2008
There exists a remarkable correlation between genetic distance and time of species divergence as inferred from fossil records. This observation has provoked the molecular clock hypothesis.
Shi Huang
core   +2 more sources

Population genetic structure of Fusarium verticillioides the causal agent of corn crown and root rot in Ilam province using Microsatellite markers

Journal of Crop Protection, 2020
Analysis of genetic diversity of Fusarium verticillioides populations concludes different levels of information in management of crown and root rot disease in corn farms.
Ahmad Seydi nezhad, Khoshnood Nourollahi
doaj  

Optimizing hybrid vigor: a comprehensive analysis of genetic distance and heterosis in eggplant landraces. [PDF]

Front Plant Sci, 2023
Rajan N, Debnath S, Perveen K, Khan F, Pandey B, Srivastava A, Khanam MN, Subramaniyan V, Kumarasamy V, Paul PJ, Lal M.   +10 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Sequencing of the Complete Mitochondrial Genome of the Big Brown Mactra Clam, Mactra grandis (Venerida: Mactridae)

Animals
Mitochondrial genomes are playing an increasingly important role in molluscan taxonomy, germplasm, and evolution studies. The first complete mitochondrial genome of the commercial big brown mactra clam, Mactra grandis, was characterized using Illumina ...
Peizhen Ma, Zhihong Liu, Zhuanzhuan Li, Xiujun Sun, Liqing Zhou, Xiangyu Wu, Biao Wu   +6 more
doaj   +1 more source

Maximization through optimization? On the relationship between hybrid performance and parental genetic distance. [PDF]

Theor Appl Genet, 2023
Würschum T, Zhu X, Zhao Y, Jiang Y, Reif JC, Maurer HP.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Towards Normalizing the Edit Distance Using a Genetic Algorithms Based\n Scheme [PDF]

, 2013
Muhammad Marwan Muhammad Fuad
openalex   +1 more source

A Novel Information-Theory-Based Genetic Distance That Approximates Phenotypic Differences. [PDF]

J Comput Biol, 2023
Campo DS, Mosa A, Khudyakov Y.
europepmc   +1 more source