Results 91 to 100 of about 4,426,309 (359)
Genetic diversity of local cattle*
Acta Biochimica Polonica, 2018 The Slovak Pinzgau breed faces the bottleneck effect and the loss of diversity due to unequal use of founders and significant population decline. Further population size reduction can lead to serious problems. High-throughput genotypes of 179 individuals were used to characterise genetic diversity and differentiation of Slovak Pinzgau, Austrian Pinzgau,Radovan Kasarda, Gábor Mészáros, Mojca Simčič, Ino Curik, Nina Moravčíková, Veronika Kukučková +5 moreopenaire +4 more sourcesGoodbye flat lymphoma biology
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes +3 morewiley +1 more sourceThe power of genetic diversity in genome-wide association studies of lipids
Nature, 2021 S. Graham, S. Clarke, Kuan-Han H. Wu, S. Kanoni, G. Zajac, S. Ramdas, I. Surakka, I. Ntalla, S. Vedantam, T. Winkler, A. Locke, E. Marouli, M. Y. Hwang, Sohee Han, A. Narita, A. Choudhury, A. Bentley, K. Ekoru, A. Verma, B. Trivedi, H. Martin, K. Hunt, Q. Hui, D. Klarin, Xiang Zhu, G. Thorleifsson, A. Helgadóttir, D. Gudbjartsson, H. Hólm, I. Olafsson, M. Akiyama, S. Sakaue, C. Terao, M. Kanai, Wei Zhou, B. Brumpton, H. Rasheed, S. Ruotsalainen, A. Havulinna, Y. Veturi, Q. Feng, E. Rosenthal, T. Lingren, J. Pacheco, S. Pendergrass, J. Haessler, Franco Giulianini, Y. Bradford, Jason E. Miller, A. Campbell, Kuang Lin, I. Millwood, G. Hindy, A. Rasheed, J. Faul, Wei Zhao, D. Weir, Constance Turman, Hongyan Huang, M. Graff, A. Mahajan, Michael R. Brown, Weihua Zhang, Ketian Yu, Ellen M. Schmidt, Anita Pandit, S. Gustafsson, X. Yin, J. Luan, Jinghua Zhao, F. Matsuda, Hye-Mi Jang, Kyungheon Yoon, C. Medina-Gomez, A. Pitsillides, J. Hottenga, G. Willemsen, A. Wood, Y. Ji, Zishan Gao, S. Haworth, R. Mitchell, Jin-Fang Chai, M. Aadahl, Jie Yao, A. Manichaikul, H. Warren, J. Ramírez, J. Bork-Jensen, L. Kårhus, A. Goel, M. Sabater-Lleal, R. Noordam, C. Sidore, E. Fiorillo, Aaron F. McDaid, P. Marques-Vidal, M. Wielscher, S. Trompet, N. Sattar, L. Møllehave, B. Thuesen, M. Munz, Lingyao Zeng, Jianfeng Huang, Bin Yang, A. Poveda, A. Kurbasic, C. Lamina, L. Forer, M. Scholz, T. Galesloot, J. Bradfield, E. W. Daw, J. Zmuda, J. Mitchell, C. Fuchsberger, Henry Christensen, Jennifer A. Brody, M. Feitosa, M. Wojczynski, Michael H. Preuss, M. Mangino, P. Christofidou, N. Verweij, J. Benjamins, J. Engmann, R. Kember, R. Slieker, K. S. Lo, Nuno R Zilhao, P. Le, M. Kleber, G. Delgado, Shaofeng Huo, Daisuke D Ikeda, Hiroyuki Iha, Jian Yang, Jun Liu, H. Leonard, J. Marten, B. Schmidt, Marina Arendt, L. Smyth, M. Cañadas-Garre, Chaolong Wang, M. Nakatochi, A. Wong, N. Hutri-Kähönen, X. Sim, Rui Xia, A. Huerta-Chagoya, J. Fernández-López, V. Lyssenko, Meraj Ahmed, A. Jackson, M. Irvin, C. Oldmeadow, Han-Na Kim, S. Ryu, P. Timmers, L. Arbeeva, R. Dorajoo, L. Lange, Xiaoran Chai, Gauri Prasad, L. Lorés-Motta, Marc Pauper, J. Long, Xiaohui Li, E. Theusch, F. Takeuchi, Cassandra N. Spracklen, A. Loukola, S. Bollepalli, S. Warner, Y. X. Wang, W. Wei, T. Nutile, D. Ruggiero, Y. Sung, Y. Hung, Shufeng Chen, Fangchao Liu, Jingyun Yang, K. Kentistou, Mathias Gorski, M. Brumat, K. Meidtner, L. Bielak, Jennifer A. Smith, Prashantha Hebbar, Aliki-Eleni Farmaki, E. Hofer, Maoxuan Lin, C. Xue, Jifeng Zhang, M. P. Concas, S. Vaccargiu, Peter J. van der Most, N. Pitkänen, B. Cade, Jiwon Lee, S. W. van der Laan, K. Chitrala, S. Weiss, M. Zimmermann, Jong Young Lee, Hyeok Sun Choi, M. Nethander, S. Freitag-Wolf, L. Southam, N. W. Rayner, Carol A. Wang, Shih-Yi Lin, Jun-Sing Wang, C. Couture, L. Lyytikäinen, K. Nikus, G. Cuéllar-Partida, H. Vestergaard, Bertha Hildalgo, O. Giannakopoulou, Q. Cai, M. Obura, J. van Setten, Xiaoyin Li, K. Schwander, N. Terzikhan, J. Shin, R. Jackson, A. Reiner, L. Martin, Zhengming Chen, Liming Li, H. Highland, K. Young, T. Kawaguchi, J. Thiery, J. Bis, G. Nadkarni, L. Launer, Huaixing Li, M. Nalls, O. Raitakari, S. Ichihara, S. Wild, C. Nelson, H. Campbell, S. Jäger, T. Nabika, F. Al-Mulla, H. Niinikoski, P. Braund, I. Kolčić, P. Kovacs, Tota Giardoglou, T. Katsuya, K. F. Bhatti, D. D. de Kleijn, G. D. de Borst, E. Kim, H. Adams, M. A. Ikram, Xiaofeng Zhu, F. Asselbergs, A. Kraaijeveld, J. Beulens, X. Shu, L. Rallidis, O. Pedersen, T. Hansen, P. Mitchell, A. Hewitt, M. Kähönen, L. Pérusse, C. Bouchard, A. Tönjes, Y. Chen, C. Pennell, Trevor A. Mori, W. Lieb, A. Franke, C. Ohlsson, D. Mellström, Y. Cho, Hyejin Lee, Jian-Min Yuan, W. Koh, S. Rhee, J. Woo, I. Heid, K. Stark, H. Völzke, G. Homuth, M. Evans, A. Zonderman, O. Polašek, G. Pasterkamp, I. Hoefer, S. Redline, K. Pahkala, A. Oldehinkel, H. Snieder, G. Biino, R. Schmidt, H. Schmidt, Y. E. Chen, S. Bandinelli, G. Dedoussis, T. Thanaraj, S. Kardia, N. Kato, M. Schulze, G. Girotto, B. Jung, C. Böger, Peter K. Joshi, D. Bennett, P. D. De Jager, Xiangfeng Lu, Vasiliki Mamakou, Morris J. Brown, M. Caulfield, P. Munroe, Xiuqing Guo, M. Ciullo, J. Jonas, N. Samani, J. Kaprio, P. Pajukanta, L. Adair, Sonny A Bechayda, H. J. de Silva, A. R. Wickremasinghe, R. Krauss, Jer-Yuarn Wu, W. Zheng, A. D. den Hollander, D. Bharadwaj, A. Correa, James G. Wilson, L. Lind, C. Heng, A. Nelson, Y. Golightly, James F. Wilson, B. Penninx, Hyung-Lae Kim, J. Attia, R. Scott, D. Rao, D. Arnett, M. Walker, H. Koistinen, G. Chandak, C. Yajnik, J. Mercader, Teresa Tusié-Luna, C. Aguilar-Salinas, Clicerio González Villalpando, L. Orozco, M. Fornage, E. Tai, R. V. van Dam, T. Lehtimäki, N. Chaturvedi, Mitsuhiro Yokota, J. Liu, Dermot F. Reilly, A. McKnight, F. Kee, K. Jöckel, M. McCarthy, C. Palmer, V. Vitart, C. Hayward, E. Simonsick, C. V. van Duijn, F. Lu, J. Qu, H. Hishigaki, Xu Lin, W. März, E. Parra, M. Cruz, V. Gudnason, J. Tardif, G. Lettre, L. T. ’t Hart, P. Elders, S. Damrauer, M. Kumari, M. Kivimaki, P. van der Harst, T. Spector, R. Loos, M. Province, B. Psaty, I. Brandslund, P. Pramstaller, K. Christensen, S. Ripatti, E. Widén, H. Hakonarson, S. Grant, L. Kiemeney, J. de Graaf, M. Loeffler, F. Kronenberg, D. Gu, J. Erdmann, H. Schunkert, P. Franks, A. Linneberg, J. Jukema, A. Khera, M. Männikkö, M. Jarvelin, Z. Kutalik, F. Cucca, D. Mook-Kanamori, K. W. van Dijk, H. Watkins, D. Strachan, N. Grarup, P. Sever, N. Poulter, J. Rotter, T. Dantoft, F. Karpe, M. Neville, N. Timpson, Ching-Yu Cheng, T. Wong, C. Khor, C. Sabanayagam, A. Peters, C. Gieger, A. Hattersley, N. Pedersen, P. Magnusson, D. Boomsma, E. D. de Geus, L. Cupples, J. V. van Meurs, M. Ghanbari, P. Gordon-Larsen, Wei Huang, Y. J. Kim, Y. Tabara, N. Wareham, C. Langenberg, E. Zeggini, J. Kuusisto, M. Laakso, E. Ingelsson, G. Abecasis, J. Chambers, J. Kooner, P. D. de Vries, A. Morrison, K. North, M. Daviglus, P. Kraft, N. Martin, J. Whitfield, S. Abbas, D. Saleheen, R. Walters, M. Holmes, C. Black, Blair H. Smith, A. Justice, A. Baras, J. Buring, P. Ridker, D. Chasman, C. Kooperberg, Wei-Qi Wei, G. Jarvik, B. Namjou, M. Hayes, M. Ritchie, P. Jousilahti, V. Salomaa, K. Hveem, B. Åsvold, M. Kubo, Y. Kamatani, Y. Okada, Y. Murakami, U. Thorsteinsdóttir, K. Stefánsson, Y. Ho, J. Lynch, D. Rader, P. Tsao, Kyong‐Mi Chang, Kelly Cho +499 moresemanticscholar +1 more sourceWhole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
Nature Communications, 2015 Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and insights into both disease etiology and targeted intervention are needed. A total of 109 micro-dissected PDA cases were subjected to whole-exome sequencing. Microdissection enriches tumour A. Witkiewicz, E. McMillan, U. Balaji, GuemHee Baek, Wan-chi Lin, J. Mansour, M. Mollaee, K. Wagner, P. Koduru, A. Yopp, M. Choti, C. Yeo, P. Mccue, M. White, E. Knudsen +14 moresemanticscholar +1 more sourceFrom omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.Siobhán O'Sullivan, Lu Qi, Pierre Zalloua +2 morewiley +1 more sourceRedox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen +8 morewiley +1 more source
