Results 81 to 90 of about 4,280,209 (308)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Ecology: Linking Species Diversity and Genetic Diversity [PDF]

Current Biology, 2005
Although there is a great deal of interest in the biological diversity of species and of genes, it is only recently that researchers have begun to investigate the processes that exert parallel influences on these different levels of diversity.
openaire   +2 more sources

Beech leaf disease symptom detection using deep learning and computer vision tools

Journal of Nematology
Beech leaf disease (BLD) has rapidly emerged as a significant threat to forests across the eastern United States and Canada, and early detection is a major challenge.
Waldo Benjamin D., Vieira Paulo, Borden Matthew A., Li Shiguang   +3 more
doaj   +1 more source

Adapting to the enemy: Rice yellow mottle virus (RYMV) evolutionary dynamics and durable resistance in African rice

Journal of Integrative Agriculture
Rice yellow mottle virus (RYMV) is one of the most destructive viral diseases affecting rice production in sub-Saharan Africa (SSA), where increasing demand and persistent yield gaps continue to compromise food security.
Isaac Tawiah, Richard Akromah, Alexander Wereko Kena, Charles Kodia Kwoseh, Shailesh Yadav, Kossi Lorimpo Adjah, Geoffrey Onaga, Benjamin Annor, Zenna Negussie, Tella Hamidatou Euridice, Scholastica Quaicoe, Nana Kofi Abaka Amoah   +11 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

List of Type Specimens Deposited Since 1998 in the United States Department of Agriculture Nematode Collection, Beltsville, Maryland [PDF]

Journal of Nematology, 2018
Zafar A. Handoo, Mihail R. Kantor, Lynn K. Carta, David J. Chitwood   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source