Results 131 to 140 of about 780,483 (315)

Genome Assembly and Annotation of the Alfalfa Cyst Nematode (Heterodera medicaginis)

open access: yesJournal of Nematology
The alfalfa cyst nematode (Heterodera medicaginis) is an invasive and pathogenic species parasitizing the agriculturally important forage crop alfalfa (Medicago sativa L.). To date, no genome assembly of H. medicaginis has been reported in the literature.
Postnikova Olga A.   +4 more
doaj   +1 more source

The Computational Complexity of Genetic Diversity.

open access: yes, 2016
A key question in biological systems is whether genetic diversity persists in the long run under evolutionary competition, or whether a single dominant genotype emerges. Classic work by [Kalmus, J. og Genetics, 1945] has established that even in simple diploid species (species with chromosome pairs) diversity can be guaranteed as long as the ...
Mehta, Ruta   +3 more
openaire   +3 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

From anarchy to clarity, data pre‐processing and statistical choices influence quantitative environmental DNA (eDNA) analyses

open access: yesMethods in Ecology and Evolution
Environmental DNA (eDNA) analyses hold great potential for increasing species detection sensitivities and estimating species abundances. The rapidly growing user base, continuous method development and optimisation have led to diverse approaches for ...
Jonas Bylemans   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Genetic diversity and disease susceptibility

open access: yesPhilosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1997
The range of genetic diversity within human populations is enormous. Genetic susceptibility to common chronic disease is a significant part of this genetic diversity, which also includes a variety of rare, clear–cut, inherited diseases. Modern DNA–based genomic analysis can now routinely lead to the identification of genes involved in disease ...
openaire   +4 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Genetic diversity and population structure of locally adapted South African chicken lines: Implications for conservation. [PDF]

open access: yes, 2008
In this study microsatellite markers were applied to investigate the genetic diversity and population structure of the six local chicken lines kept in the “Fowls for Africa” program, for better clarification of parameters for breed differentiation and ...
Hefer, C.A.   +3 more
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Microsatellite markers reveal genetic diversity and population genetic structure of the threatened Martaban camphor [Cinnamomum parthenoxylon (Jack) Meisn] [PDF]

open access: yes
Martaban camphor [Cinnamomum parthenoxylon (Jack) Meisn] is a woody tree in India, China, Indonesia, Thailand, and Vietnam and has been widely utilized for commercial purposes.
M.P. Pham   +5 more
core   +1 more source

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