Results 121 to 130 of about 641,007 (266)

Evaluating genetic diversity differences within a likelihood framework. [PDF]

PLoS One
Nickle DC.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Festulolium and fungal endophyte associations: host status for Meloidogyne incognita and nematotoxic plant extracts [PDF]

Journal of Nematology, 2020
Susan L. F. Meyer, Brian J. Patchett, Timothy J. Gillanders, Mihail R. Kantor, Patricia Timper, Margaret H. MacDonald   +5 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Phylogeography and genetic diversity of Pieris rapae across continents. [PDF]

PLoS One
Siam MAH, Dey D, Owaresat JK, Khan YS, Anowar E, Maya JF, Siddiki AZ.   +6 more
europepmc   +1 more source

The Computational Complexity of Genetic Diversity.

, 2016
A key question in biological systems is whether genetic diversity persists in the long run under evolutionary competition, or whether a single dominant genotype emerges. Classic work by [Kalmus, J. og Genetics, 1945] has established that even in simple diploid species (species with chromosome pairs) diversity can be guaranteed as long as the ...
Mehta, Ruta, Panageas, Ioannis, Piliouras, Georgios, Yazdanbod, Sadra   +3 more
openaire   +3 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Human Cytomegalovirus Genetic Diversity, Clinical Relevance, and Emerging Insights. [PDF]

Rev Med Virol
AlQahtani HY, Aleanizy FS, Alqahtani FY.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Strengthening the economic sustainability of community seed banks. A sustainable approach to enhance agrobiodiversity in the production systems in low-income countries

Frontiers in Sustainable Food Systems, 2022
Eleonora De Falcis, Devendra Gauchan, Devendra Gauchan, Rose Nankya, Sergio Martinez Cotto, Devra I. Jarvis, Devra I. Jarvis, Laura Lewis, Paola De Santis, Paola De Santis, Paola De Santis   +10 more
doaj   +1 more source