Results 161 to 170 of about 780,483 (315)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Improved 18S small subunit rDNA primers for problematic nematode amplification [PDF]

Journal of Nematology, 2018
L. K. Carta, S. Li
doaj   +1 more source

Leveraging Genetic Diversity for Abiotic Stress Tolerance. [PDF]

Int J Mol Sci
Cortés AJ.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Genetic Diversity in Dutch Sheep Breeds. [PDF]

Anim Genet
Hoorneman JN, Schoon MA, Crooijmans RPMA, Hiemstra SJ, Windig JJ.   +4 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Minimising Risks of Reduced Genetic Diversity in Marine Restoration. [PDF]

Evol Appl
Wood G, Filbee-Dexter K, Wernberg T, Coleman MA.   +3 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Using Economics to Explain Spatial Diversity in a Wheat Crop: Examples from Australia and China [PDF]

Spatial diversity indicators may serve an important function for policymakers as they seek to manage crop genetic diversity and potential externalities associated with diffusion of some types of genetically improved crops.
Hu, Ruifa, Meng, Erika C.H., Brennan, John P., Smale, Melinda   +3 more
core   +1 more source

Festulolium and fungal endophyte associations: host status for Meloidogyne incognita and nematotoxic plant extracts [PDF]

Journal of Nematology, 2020
Susan L. F. Meyer, Brian J. Patchett, Timothy J. Gillanders, Mihail R. Kantor, Patricia Timper, Margaret H. MacDonald   +5 more
doaj   +1 more source