Results 171 to 180 of about 780,483 (315)

Genetic Diversity Impacts Climate-Induced Species Range Shifts. [PDF]

Ecol Lett
Oliveira BF, Bertrand R, Comte L, Lenoir J, Grenouillet G, Lancaster LT, Murienne J, Diamond S, Scheffers BR, Bandara RMWJ, Lawlor JA, Moore NA, Wolfe BW, Villalobos F, Weiskopf SR, Thompson LM, Pinsky ML, Rolland J.   +17 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Genetic diversity and distribution pattern responses of <i>Picea asperata</i>. [PDF]

Front Plant Sci
Chen Q, Tang X, Yin Y, Ru D, Feng S.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Strengthening the economic sustainability of community seed banks. A sustainable approach to enhance agrobiodiversity in the production systems in low-income countries

Frontiers in Sustainable Food Systems, 2022
Eleonora De Falcis, Devendra Gauchan, Devendra Gauchan, Rose Nankya, Sergio Martinez Cotto, Devra I. Jarvis, Devra I. Jarvis, Laura Lewis, Paola De Santis, Paola De Santis, Paola De Santis   +10 more
doaj   +1 more source

Differences in mainland-island genetic diversity in two moths suggest species-specific outcomes. [PDF]

PLoS One
Choi SW, Jin DH, An H, Nam K, Shin B.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Demand and Supply of Crop Infraspecific Diversity on Farms: Towards a Policy Framework for On-Farm Conservation [PDF]

Interest is increasing worldwide in on-farm conservation as a component of a strategy to conserve crop genetic resources. On-farm conservation may require outside support to small-scale farmers in areas of crop domestication and diversity.
Bellon, Mauricio R.
core   +1 more source

Allele Frequency Spectra as a General Tool for Modeling Genetic Diversity. [PDF]

Acta Biotheor
Hössjer O, Laikre L, Ryman N.
europepmc   +1 more source