Results 181 to 190 of about 641,007 (266)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Uniform bacterial genetic diversity along the gut. [PDF]

Nat Commun
Wasney M, Briscoe L, Wolff R, Ghezzi H, Tropini C, Garud N.   +5 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Analysis of Inbreeding, Population Structure, and Genetic Diversity in the Kumamoto Sub-Breed of Japanese Brown Cattle. [PDF]

Animals (Basel)
Wang T, Inoue K, Ichinoseki K, Takeda M, Fukuzawa Y, Ozaki T, Peng W, Wang G, Ishida T.   +8 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Why conserve genetic diversity? A perspective based on a case study with a European conifer. [PDF]

Ann Bot
Fady B, Scotti-Saintagne C.
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

The evolutionary history and unique genetic diversity of Indigenous Americans. [PDF]

Nature
Castro E Silva MA, Nunes K, Ribeiro MR, Passarelli-Araujo H, Lemes RB, Kimura L, Sacuena P, G Amorim CE, Bortolini MC, Mill JG, Guerreiro JF, Barbieri C, Hernández-Zaragoza DI, Walter A, Chowdhury TN, Macías-Herrera D, Lara-Riegos JC, Del Castillo-Chávez O, Zurita C, Tito-Álvarez AM, Vásquez-Domínguez E, Moo-Mezeta ME, Torres-Romero JC, Aguilar-Campos A, Serrano-Osuna R, Parolín ML, Bravi CM, Ramallo V, Bailliet G, Revollo S, Sandoval JR, Fujita R, Barquera R, Santos FR, Comas D, Hünemeier T.   +35 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Monitoring genetic diversity of Torminalis glaberrima for resilient forests in the face of population fragmentation. [PDF]

Ann Bot
Afifi L, Szukala A, Klumpp R, Tremetsberger K, Konrad H.   +4 more
europepmc   +1 more source