Results 141 to 150 of about 3,031,778 (313)

Genetic drift [PDF]

Journal of Cell Science, 2009
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

What does effective population size tell us about loss of allelic variation?

Evolutionary Applications
There are two primary measures of the amount of genetic variation in a population at a locus: heterozygosity and the number of alleles. Effective population size (Ne) provides both an expectation of the amount of heterozygosity in a population at drift ...
Fred W. Allendorf, Ola Hössjer, Nils Ryman   +2 more
doaj   +1 more source

Genetic point mutation inducing antigenic drift in hypervariable region of a very virulent IBDV isolate in chickens in Egypt during 2014-2016 [PDF]

, 2019
Hany Ellakany, Ahmed R. Elbestawy, Ahmed Sayed-Ahmed, Samia Elgammal, Ahmed R. Gado, Hatem Abdel-Hameed   +5 more
openalex   +1 more source

Random Genetic Drift: A Non-directional Force of Evolution

, 2022
B. N. Singh
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Genetic drift [PDF]

Nature, 1993
openaire   +1 more source

Effect of Selection on the Genetic Structure of the Population with the Presence or Absence of Genetic Drift

, 2017
Shahrzad Nokhbeh Zaeem
openalex   +1 more source

From Understanding Genetic Drift to a Smart-Restart Mechanism for Estimation-of-Distribution Algorithms [PDF]

, 2022
Weijie Zheng, Benjamin Doerr
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source