Results 191 to 200 of about 3,031,778 (313)

Genomic consequences of colonisation, migration and genetic drift in barn owl insular populations of the eastern Mediterranean. [PDF]

Mol Ecol, 2022
Machado AP, Topaloudis A, Cumer T, Lavanchy E, Bontzorlos V, Ceccherelli R, Charter M, Kassinis N, Lymberakis P, Manzia F, Ducrest AL, Dupasquier M, Guex N, Roulin A, Goudet J.   +14 more
europepmc   +1 more source

Genetic drift and mutational hazard in the evolution of salamander genomic gigantism

Evolution; international journal of organic evolution, 2016
Erik Roger Mohlhenrich, R. Mueller
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Random Penetrance of Mutations Among Individuals: A New Type of Genetic Drift in Molecular Evolution. [PDF]

Phenomics, 2021
Gu X.
europepmc   +1 more source

EFFECTS OF GENETIC DRIFT ON VARIANCE COMPONENTS UNDER A GENERAL MODEL OF EPISTASIS [PDF]

, 2004
Nick Barton, Michael Turelli
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Harvest and decimation affect genetic drift and the effective population size in wild reindeer. [PDF]

Evol Appl
Kvalnes T, Flagstad Ø, Våge J, Strand O, Viljugrein H, Sæther BE.   +5 more
europepmc   +1 more source

Correction to: Genetic Drift Shapes the Evolution of a Highly Dynamic Metapopulation. [PDF]

Mol Biol Evol, 2023
europepmc   +1 more source

Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes.

Cell Stem Cell, 2016
Mitsutoshi Yamada, V. Emmanuele, M. Sánchez-Quintero, Bruce Sun, Gregory Lallos, Daniel Paull, M. Zimmer, Shardonay Pagett, R. Prosser, M. Sauer, M. Hirano, D. Egli   +11 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source