Results 211 to 220 of about 3,031,778 (313)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Genetic drift from the out-of-Africa bottleneck leads to biased estimation of genetic architecture and selection. [PDF]

Eur J Hum Genet, 2021
Ashraf B, Lawson DJ.
europepmc   +1 more source

Swine Influenza A Evolution via Recombination - Genetic Drift Reservoir [PDF]

, 2007
Henry Niman
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Allele Based Inference on Evolution and Extinction; A Genetic Drift Approach [PDF]

, 2019
Samuel Oluwafemi Oyamakin, Angela Chukwu, Wale-Orojo Oluwaseun A, Ogunjobi E. O   +3 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Worldwide variation of the COL14A1 gene is shaped by genetic drift rather than selective pressure. [PDF]

Mol Genet Genomic Med, 2021
Calò CM, Onali F, Robledo R, Flore L, Massidda M, Francalacci P.   +5 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Influenza A genomic diversity during human infections underscores the strength of genetic drift and the existence of tight transmission bottlenecks. [PDF]

Virus Evol
Martin MA, Berg N, Koelle K.
europepmc   +1 more source

Do chromosome rearrangements fix by genetic drift or natural selection? A test inBrenthisbutterflies

, 2023
Mackintosh A, Vila R, Martin SH, Setter D, Lohse K.   +4 more
europepmc   +1 more source