Results 171 to 180 of about 5,820,249 (380)

Novel Drug Targets for Neurodegenerative Diseases of Elderly People to Develop Effective Therapeutics: A Comprehensive Analysis

Advances in Pharmacological and Pharmaceutical Sciences
Neurodegenerative diseases (NDs) represent an increasingly important burden of disease, particularly in the aging population. The etiology of NDs like Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) is associated with ...
Partha Biswas, MD. Hasanur Rahman, Afrida Tabassum, Tanvir Zaman Shoyshob, Maroua Jalouli, Md. Mohaimenul Islam Tareq, Md. Imtiaz, Humayra Afroz Dona, Abdel Halim Harrath, Md Ataur Rahman   +9 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Selected problems of legal regulation of genetic engineering activities in RF

, 2021
K.V. Arapov, O.L. Konovalenko
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Trends in the Growth of Literature on Genetic Engineering

, 2014
A. Mareeswari, P. Vinayagamoorthy, Jayapradha Ramakrishnan, J. Shanth   +3 more
openalex   +2 more sources

The VI-th International Consultative Council of the Institute of Genetic Engineering, Kostinbrod, Bulgaria 19–21 October, 2000, Sofia, Bulgaria Conclusions and Recommendations [PDF]

, 2000

openalex   +1 more source

TECHNОLОGY ОF GENETIC ENGINEERING ОF INSULIN FRОM MICRООRGАNISMS

, 2023
Muhammadjon Mustafakulov Abdumannon Uralov Dilyorbek Ganijanov Bobur Anvarov Tоshbekоv Nurmuhаmmаd
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

An update and perspectives on the use of promoters in plant genetic engineering

Journal of Biosciences, 2020
Divya Kummari, Divya Kummari, S. R. Palakolanu, P. B. K. Kishor, P. Bhatnagar-Mathur, P. Singam, V. Vadez, K. Sharma   +7 more
semanticscholar   +1 more source