Results 31 to 40 of about 735,632 (337)

Circulating Levels of the Short-Chain Fatty Acid Acetate Mediate the Effect of the Gut Microbiome on Visceral Fat

Frontiers in Microbiology, 2021
BackgroundAcetate is a short-chain fatty acid (SCFA) produced by gut bacteria, which has been implicated in cardio-metabolic health. Here we examine the relationships of circulating acetate levels with gut microbiome composition and diversity and with ...
Ana Nogal, Panayiotis Louca, Xinyuan Zhang, Philippa M. Wells, Claire J. Steves, Tim D. Spector, Mario Falchi, Ana M. Valdes, Ana M. Valdes, Cristina Menni   +9 more
doaj   +1 more source

A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness. [PDF]

, 2020
Gastrointestinal infections can be life threatening, but not much is known about the host's genetic contribution to susceptibility to gastrointestinal infections or the latter's association with psychiatric disorders.
Appadurai, Vivek, Benros, Michael E, Buil, Alfonso, Bybjerg-Grauholm, Jonas, Børglum, Anders D, Daly, Mark J, Hougaard, David M, Mors, Ole, Mortensen, Preben Bo, Nordentoft, Merete, Nudel, Ron, Schork, Andrew J, Thompson, Wesley K, Werge, Thomas   +13 more
core   +2 more sources

ImputAccur: fast and user-friendly calculation of genotype-imputation accuracy-measures

BMC Bioinformatics, 2022
Background ImputAccur is a software tool to measure genotype-imputation accuracy. Imputation of untyped markers is a standard approach in genome-wide association studies to close the gap between directly genotyped and other known DNA variants.
Kolja A. Thormann, Viola Tozzi, Paula Starke, Heike Bickeböller, Marcus Baum, Albert Rosenberger   +5 more
doaj   +1 more source

Epidemiology and etiology of meningioma. [PDF]

, 2010
Although most meningiomas are encapsulated and benign tumors with limited numbers of genetic aberrations, their intracranial location often leads to serious and potentially lethal consequences.
Claus, Elizabeth B, Wiemels, Joseph, Wrensch, Margaret   +2 more
core   +4 more sources

Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

Clinical Epigenetics, 2018
Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to ...
Pei-Chien Tsai, Craig A. Glastonbury, Melissa N. Eliot, Sailalitha Bollepalli, Idil Yet, Juan E. Castillo-Fernandez, Elena Carnero-Montoro, Thomas Hardiman, Tiphaine C. Martin, Alice Vickers, Massimo Mangino, Kirsten Ward, Kirsi H. Pietiläinen, Panos Deloukas, Tim D. Spector, Ana Viñuela, Eric B. Loucks, Miina Ollikainen, Karl T. Kelsey, Kerrin S. Small, Jordana T. Bell   +20 more
doaj   +1 more source

Association of circulating leptin, adiponectin, and resistin concentrations with long-term breast cancer prognosis in a German patient cohort

Scientific Reports, 2021
Adipokines including leptin, adiponectin and resistin have been linked to risk of obesity-related cancers potentially through low-grade chronic inflammation pathways.
Nadia Obi, Audrey Y. Jung, Tabea Maurer, Marianne Huebner, Theron Johnson, Sabine Behrens, Stefanie Jaskulski, Heiko Becher, Jenny Chang-Claude   +8 more
doaj   +1 more source

Common variation near ROBO2 is associated with expressive vocabulary in infancy [PDF]

, 2014
Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers
Ang, Qi W., Cents, Rolieke A. M., Dale, Philip S., Davis, Oliver S. P., Evans, David M., Golding, Jean, Haworth, Claire M. A., Hofman, A., Jaddoe, Vincent Wilfred Vishal-Kapoor, Jarvelin, Marjo-Riitta, Kemp, John P., Meaburn, Emma L., Miller, Laura, O’Reilly, Paul F., Pennell, Craig E., Pillas, Demetris, Plomin, Robert, Price, Tom S., Ring, Susan M., Rivadeneira, Fernando, Rodriguez, Alina, Roulstone, Susan, Smith, George Davey, St Pourcain, Beate, Tiemeier, Henning, Timpson, Nicholas J., Velders, F. P., Verhulst, F. C., Warrington, Nicole M., Whitehouse, Andrew J. O., Wren, Yvonne, Yliherva, Anneli   +31 more
core   +9 more sources

Oropouche virus: clinical, epidemiological, and molecular aspects of a neglected orthobunyavirus. [PDF]

, 2017
Oropouche virus (OROV) is an important cause of arboviral illness in Latin American countries, more specifically in the Amazon region of Brazil, Venezuela and Peru, as well as in other countries such as Panama.
Acrani, Gustavo Olszanski, Cardoso, Jedson Ferreira, da Rosa, Jorge Fernando Travassos, de Paula Pinheiro, Francisco, de Souza, William Marciel, Figueiredo, Mário Luiz, Nunes, Márcio Roberto Teixeira   +6 more
core   +1 more source

Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers

Genome Medicine, 2022
Background There is considerable evidence for the importance of the DNA methylome in metabolic health, for example, a robust methylation signature has been associated with body mass index (BMI).
Colette Christiansen, Max Tomlinson, Melissa Eliot, Emma Nilsson, Ricardo Costeira, Yujing Xia, Sergio Villicaña, Olatz Mompeo, Philippa Wells, Juan Castillo-Fernandez, Louis Potier, Marie-Claude Vohl, Andre Tchernof, Julia El-Sayed Moustafa, Cristina Menni, Claire J. Steves, Karl Kelsey, Charlotte Ling, Elin Grundberg, Kerrin S. Small, Jordana T. Bell   +20 more
doaj   +1 more source

Resolving intra-repeat variation in medically relevant VNTRs from short-read sequencing data using the cardiovascular risk gene LPA as a model

Genome Biology
Background Variable number tandem repeats (VNTRs) are highly polymorphic DNA regions harboring many potentially disease-causing variants. However, VNTRs often appear unresolved (“dark”) in variation databases due to their repetitive nature.
Silvia Di Maio, Peter Zöscher, Hansi Weissensteiner, Lukas Forer, Johanna F. Schachtl-Riess, Stephan Amstler, Gertraud Streiter, Cathrin Pfurtscheller, Bernhard Paulweber, Florian Kronenberg, Stefan Coassin, Sebastian Schönherr   +11 more
doaj   +1 more source