Results 41 to 50 of about 731,889 (291)

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

Genome-wide identification of RNA modification-related single nucleotide polymorphisms associated with rheumatoid arthritis

BMC Genomics, 2023
Background RNA modification plays important roles in many biological processes, such as gene expression control. The aim of this study was to identify single nucleotide polymorphisms related to RNA modification (RNAm-SNPs) for rheumatoid arthritis (RA ...
Mimi Wang, Jingyun Wu, Shufeng Lei, Xingbo Mo   +3 more
doaj   +1 more source

Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright, Morgan A. Paul, Selena Murcia Mendez, Emily Jones, Lucille Lokko, Chelsea Heneghan, Nicholas Purol, Morgan Arnold, Rahela Aziz‐Bose, Colleen A. Kelly, Sandi L. Pruitt, Joanne Wolfe, Kira Bona, Puja J. Umaretiya   +13 more
wiley   +1 more source

Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank

Nature Communications, 2020
Snoring is common in the population and tends to be more prevalent in older and/or male individuals. Here, the authors perform GWAS for habitual snoring, identify 41 genomic loci and explore potential causal relationships with anthropometric and ...
Adrián I. Campos, Luis M. García-Marín, Enda M. Byrne, Nicholas G. Martin, Gabriel Cuéllar-Partida, Miguel E. Rentería   +5 more
doaj   +1 more source

I am hiQ—a novel pair of accuracy indices for imputed genotypes

BMC Bioinformatics, 2022
Background Imputation of untyped markers is a standard tool in genome-wide association studies to close the gap between directly genotyped and other known DNA variants. However, high accuracy with which genotypes are imputed is fundamental.
Albert Rosenberger, Viola Tozzi, Heike Bickeböller, the INTEGRAL-ILCCO consortium   +3 more
doaj   +1 more source

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation [PDF]

, 2015
Reference panels from the 1000 Genomes (1000G) Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency ≥0.5% across European ancestry populations. Within the European Network for Genetic
Beekman, M. (Marian), Bennett, A.J. (Amanda), Blades, M. (Matthew), Boomsma, D.I. (Dorret), Bunt, M. (Martijn) van de, De Craen, A.J.M. (Anton J. M.), Deelen, J. (Joris), Duijn, C.M. (Cornelia) van, Erdmann, J. (Jeanette), Eriksson, J.G. (Johan G.), Esko, T. (Tõnu), Fernandez, J. (Juan), Ferreira, T. (Teresa), Gaulton, K. (Kyle), Geus, E.J.C. (Eco) de, Gieger, C. (Christian), Grallert, H. (Harald), Groop, L. (Leif), Groves, C.J. (Christopher), Hamsten, A. (Anders), Havulinna, A.S. (Aki), Heid, I.M. (Iris), Hengstenberg, C. (Christian), Herder, C. (Christian), Horikoshi, M. (Momoko), Hottenga, J.J. (Jouke Jan), Houwing-Duistermaat, J.J. (Jeanine), Hypponen, E. (Elina), Hӓgg, S. (Sara), Ingelsson, E. (Erik), Isaacs, A.J. (Aaron), Jula, A. (Antti), Kaprio, J. (Jaakko), Karssen, L.C. (Lennart), Ladenvall, C. (Claes), Leeuwen, E.M. (Elisa) van, Lehtimӓki, T. (Terho), Lind, L. (Lars), Lindgren, C.M. (Cecilia M.), Lyssenko, V. (Valeriya), Magnusson, P.K.E. (Patrik K. E.), Mahajan, A. (Anubha), Marullo, L. (Letizia), McCarthy, M.I. (Mark), Metspalu, A. (Andres), Mihailov, E. (Evelin), Milaneschi, Y. (Yuri), Morris, A.P. (Andrew), Müller-Nurasyid, M. (Martina), Mӓgi, R. (Reedik), Nelson, C.P. (Christopher P.), Pedersen, N.L. (Nancy L.), Penninx, B.W.J.H. (Brenda), Perola, M. (Markus), Pervjakova, N. (Natalia), Peters, A. (Annette), Power, C. (Christopher), Prokopenko, I. (Inga), Raitakari, O.T. (Olli T.), Ried, J.S. (Janina), Ripatti, S. (Samuli), Robertson, N.R. (Neil R.), Roden, M. (Michael), Rung, J. (Johan), Salomaa, V. (Veikko), Samani, N.J. (Nilesh), Sarin, A.-P., Schunkert, H. (Heribert), Slagboom, P.E. (Eline), Smit, J.H. (Johannes), Steinthorsdottir, V. (Valgerdur), Surakka, I. (Ida), Thorleifsson, G. (Gudmar), Thorsteinsdottir, U. (Unnur), Tobin, M.D. (Martin), Viikari, J. (Jorma), Willems, S.M. (Sara), Willemsen, G.A.H.M. (Gonneke), Willenborg, C. (Christina), Wiltshire, S. (Steven), Winkler, T.W. (Thomas W.), Zwart, J-A. (John-Anker)   +81 more
core   +1 more source

Financial Burden Associated With Hospitalisation Among Families of Childhood Brain Tumours in Australia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim, Natalie Bradford, David Brain, Sameera Senanayake, Sanjeewa Kularatna, Kate Young, Christine Cashion, Tim Hassall, Susanna Cramb   +8 more
wiley   +1 more source

Genetic-by-age interaction analyses on complex traits in UK Biobank and their potential to identify effects on longitudinal trait change

Genome Biology
Background Genome-wide association studies (GWAS) have identified thousands of loci for disease-related human traits in cross-sectional data. However, the impact of age on genetic effects is underacknowledged.
Thomas W. Winkler, Simon Wiegrebe, Janina M. Herold, Klaus J. Stark, Helmut Küchenhoff, Iris M. Heid   +5 more
doaj   +1 more source

Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients

BMC Cancer, 2018
Background Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them ...
Seyed Hamidreza Mahmoudpour, Obul Reddy Bandapalli, Miguel Inácio da Silva Filho, Chiara Campo, Kari Hemminki, Hartmut Goldschmidt, Maximilian Merz, Asta Försti   +7 more
doaj   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter, Jens‐Peter Schenk, Jenny Wegert, Manfred Gessler, Leo Kager, Stefan Wagenpfeil, Marina Müller, Jean‐Michel Wolff, Joerg Fuchs, Steven W. Warmann, Clemens‐Magnus Meier, Jochen Hubertus, Christian Rübe, Christian Vokuhl, Patrick Melchior, Lena Tschirner, Norbert Graf, Rhoikos Furtwängler   +17 more
wiley   +1 more source