Results 31 to 40 of about 2,745,050 (303)

Genetic And Environmental Epidemiology

, 2022
Genetic epidemiology is considered a newer branch of epidemiology that focuses on the etiology, distribution, and control of diseases in groups of genetically related individuals and those with inherited genetic diseases.
Porche, Demetrius J.
core   +1 more source

Genetic epidemiology of glioma [PDF]

British Journal of Cancer, 2001
The present study performed a segregation analysis of a cohort of first-degree relatives (FDR) of glioma patients. The families with two or more gliomas were also expanded to determine if any more gliomas could be detected, and if any other types of cancers were associated.
Malmer, B., Iselius, L., Holmberg, E., Collins, A., Henriksson, R., Grönberg, H.   +5 more
openaire   +4 more sources

ImputAccur: fast and user-friendly calculation of genotype-imputation accuracy-measures

BMC Bioinformatics, 2022
Background ImputAccur is a software tool to measure genotype-imputation accuracy. Imputation of untyped markers is a standard approach in genome-wide association studies to close the gap between directly genotyped and other known DNA variants.
Kolja A. Thormann, Viola Tozzi, Paula Starke, Heike Bickeböller, Marcus Baum, Albert Rosenberger   +5 more
doaj   +1 more source

Circulating Levels of the Short-Chain Fatty Acid Acetate Mediate the Effect of the Gut Microbiome on Visceral Fat

Frontiers in Microbiology, 2021
BackgroundAcetate is a short-chain fatty acid (SCFA) produced by gut bacteria, which has been implicated in cardio-metabolic health. Here we examine the relationships of circulating acetate levels with gut microbiome composition and diversity and with ...
Ana Nogal, Panayiotis Louca, Xinyuan Zhang, Philippa M. Wells, Claire J. Steves, Tim D. Spector, Mario Falchi, Ana M. Valdes, Ana M. Valdes, Cristina Menni   +9 more
doaj   +1 more source

Resolving intra-repeat variation in medically relevant VNTRs from short-read sequencing data using the cardiovascular risk gene LPA as a model

Genome Biology
Background Variable number tandem repeats (VNTRs) are highly polymorphic DNA regions harboring many potentially disease-causing variants. However, VNTRs often appear unresolved (“dark”) in variation databases due to their repetitive nature.
Silvia Di Maio, Peter Zöscher, Hansi Weissensteiner, Lukas Forer, Johanna F. Schachtl-Riess, Stephan Amstler, Gertraud Streiter, Cathrin Pfurtscheller, Bernhard Paulweber, Florian Kronenberg, Stefan Coassin, Sebastian Schönherr   +11 more
doaj   +1 more source

Association of circulating leptin, adiponectin, and resistin concentrations with long-term breast cancer prognosis in a German patient cohort

Scientific Reports, 2021
Adipokines including leptin, adiponectin and resistin have been linked to risk of obesity-related cancers potentially through low-grade chronic inflammation pathways.
Nadia Obi, Audrey Y. Jung, Tabea Maurer, Marianne Huebner, Theron Johnson, Sabine Behrens, Stefanie Jaskulski, Heiko Becher, Jenny Chang-Claude   +8 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Epidemiology and Genetic Epidemiology

, 2008
This chapter focuses on descriptive analysis in genetic epidemiology and some of its links with mainstream epidemiology. It starts with incidence and prevalence, briefly reviewing some of the relevant statistical methods, and then moves on to consider ...
J. M. Bowden, Bowden, J. M., M. D. Tobin, Burton, P. R., Tobin, M. D., P. R. Burton   +5 more
core   +1 more source

Epidemiology of colorectal cancer. [PDF]

, 2016
Colorectal cancer is currently the third deadliest cancer in the United States and will claim an estimated 49,190 U.S. lives in 2016. The purpose of this review is to summarize our current understanding of this disease, based on nationally published ...
Nan, Hongmei, Marley, Andrew R.
core   +1 more source

Nanopore sequencing with unique molecular identifiers enables accurate mutation analysis and haplotyping in the complex lipoprotein(a) KIV-2 VNTR

Genome Medicine
Background Repetitive genome regions, such as variable number of tandem repeats (VNTR) or short tandem repeats (STR), are major constituents of the uncharted dark genome and evade conventional sequencing approaches. The protein-coding LPA kringle IV type-
Stephan Amstler, Gertraud Streiter, Cathrin Pfurtscheller, Lukas Forer, Silvia Di Maio, Hansi Weissensteiner, Bernhard Paulweber, Sebastian Schönherr, Florian Kronenberg, Stefan Coassin   +9 more
doaj   +1 more source