Results 21 to 30 of about 731,889 (291)

Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci

Nature Communications, 2018
Genomic polymorphisms affect the epigenome, which in turn influences how epigenome- and genome-wide analysis are interpreted. Here, the authors characterise allelic differences in DNA methylation driven by obligatory or facilitative genetic effects ...
Christopher G. Bell, Fei Gao, Wei Yuan, Leonie Roos, Richard J. Acton, Yudong Xia, Jordana Bell, Kirsten Ward, Massimo Mangino, Pirro G. Hysi, Jun Wang, Timothy D. Spector   +11 more
doaj   +1 more source

Leishmania donovani populations in Eastern Sudan: temporal structuring and a link between human and canine transmission. [PDF]

, 2014
BACKGROUND: Visceral leishmaniasis (VL), caused by the members of the Leishmania donovani complex, has been responsible for devastating VL epidemics in the Sudan.
Baleela, Rania, Fitzpatrick, Sinead, Kuhls, Katrin, Llewellyn, Martin S, Mauricio, Isabel L, Miles, Michael A, Schönian, Gabriele   +6 more
core   +3 more sources

Interplay between the human gut microbiome and host metabolism

Nature Communications, 2019
Here, the authors study the interplay between the microbiome and faecal and blood metabolome, and how the microbiome interacts in the dialogue between these metabolic compartments, identifying a key role for microbial functions and underscoring their ...
Alessia Visconti, Caroline I. Le Roy, Fabio Rosa, Niccolò Rossi, Tiphaine C. Martin, Robert P. Mohney, Weizhong Li, Emanuele de Rinaldis, Jordana T. Bell, J. Craig Venter, Karen E. Nelson, Tim D. Spector, Mario Falchi   +12 more
doaj   +1 more source

The justification of studies in genetic epidemiology: political scaling in China Medical City [PDF]

, 2018
Genetic epidemiology examines the role of genetic factors in determining health and disease in families and in populations to help addressing health problems in a responsible manner.
Sleeboom-Faulkner, Margaret
core   +1 more source

KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies

BMC Bioinformatics, 2023
Background Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with kidney function. By combining these findings with post-GWAS information (e.g., statistical fine-mapping to identify independent association signals
Kira J. Stanzick, Klaus J. Stark, Mathias Gorski, Johannes Schödel, René Krüger, Florian Kronenberg, Richard Warth, Iris M. Heid, Thomas W. Winkler   +8 more
doaj   +1 more source

Validation of differentially methylated microRNAs identified from an epigenome-wide association study; Sanger and next generation sequencing approaches

BMC Research Notes, 2018
Objectives Altered DNA methylation and microRNA profiles are associated with diabetic kidney disease. This study compared different sequencing approaches to define the genetic and epigenetic architecture of sequences surrounding microRNAs associated with
Laura J. Smyth, Alexander P. Maxwell, Katherine A. Benson, Jill Kilner, Gareth J. McKay, Amy Jayne McKnight   +5 more
doaj   +1 more source

Circulating Levels of the Short-Chain Fatty Acid Acetate Mediate the Effect of the Gut Microbiome on Visceral Fat

Frontiers in Microbiology, 2021
BackgroundAcetate is a short-chain fatty acid (SCFA) produced by gut bacteria, which has been implicated in cardio-metabolic health. Here we examine the relationships of circulating acetate levels with gut microbiome composition and diversity and with ...
Ana Nogal, Panayiotis Louca, Xinyuan Zhang, Philippa M. Wells, Claire J. Steves, Tim D. Spector, Mario Falchi, Ana M. Valdes, Ana M. Valdes, Cristina Menni   +9 more
doaj   +1 more source

ImputAccur: fast and user-friendly calculation of genotype-imputation accuracy-measures

BMC Bioinformatics, 2022
Background ImputAccur is a software tool to measure genotype-imputation accuracy. Imputation of untyped markers is a standard approach in genome-wide association studies to close the gap between directly genotyped and other known DNA variants.
Kolja A. Thormann, Viola Tozzi, Paula Starke, Heike Bickeböller, Marcus Baum, Albert Rosenberger   +5 more
doaj   +1 more source

Association of circulating leptin, adiponectin, and resistin concentrations with long-term breast cancer prognosis in a German patient cohort

Scientific Reports, 2021
Adipokines including leptin, adiponectin and resistin have been linked to risk of obesity-related cancers potentially through low-grade chronic inflammation pathways.
Nadia Obi, Audrey Y. Jung, Tabea Maurer, Marianne Huebner, Theron Johnson, Sabine Behrens, Stefanie Jaskulski, Heiko Becher, Jenny Chang-Claude   +8 more
doaj   +1 more source

Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

Clinical Epigenetics, 2018
Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to ...
Pei-Chien Tsai, Craig A. Glastonbury, Melissa N. Eliot, Sailalitha Bollepalli, Idil Yet, Juan E. Castillo-Fernandez, Elena Carnero-Montoro, Thomas Hardiman, Tiphaine C. Martin, Alice Vickers, Massimo Mangino, Kirsten Ward, Kirsi H. Pietiläinen, Panos Deloukas, Tim D. Spector, Ana Viñuela, Eric B. Loucks, Miina Ollikainen, Karl T. Kelsey, Kerrin S. Small, Jordana T. Bell   +20 more
doaj   +1 more source