Results 21 to 30 of about 2,745,050 (303)

A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study

Scientific Reports, 2023
The availability of polygenic scores for type 2 diabetes (T2D) raises the question, whether assessing family history might become redundant. However, family history not only involves shared genetics, but also shared environment.
Elena Duschek, Lukas Forer, Sebastian Schönherr, Christian Gieger, Annette Peters, Florian Kronenberg, Harald Grallert, Claudia Lamina   +7 more
doaj   +1 more source

Genetic Epidemiology of Obesity [PDF]

Epidemiologic Reviews, 2007
Obesity has become a global epidemic and contributes to the increasing burden of type 2 diabetes, cardiovascular disease, stroke, some types of cancer, and premature death worldwide. Obesity is highly heritable and arises from the interactions of multiple genes, environmental factors, and behavior.
Wenjie, Yang, Tanika, Kelly, Jiang, He
openaire   +2 more sources

Interplay between the human gut microbiome and host metabolism

Nature Communications, 2019
Here, the authors study the interplay between the microbiome and faecal and blood metabolome, and how the microbiome interacts in the dialogue between these metabolic compartments, identifying a key role for microbial functions and underscoring their ...
Alessia Visconti, Caroline I. Le Roy, Fabio Rosa, Niccolò Rossi, Tiphaine C. Martin, Robert P. Mohney, Weizhong Li, Emanuele de Rinaldis, Jordana T. Bell, J. Craig Venter, Karen E. Nelson, Tim D. Spector, Mario Falchi   +12 more
doaj   +1 more source

Genetic epidemiology [PDF]

British Medical Bulletin, 1996
Studies of families, twins, and adoptees have helped to quantify the genetic contributions to and overlaps between depression, anxiety, phobias and alcoholism, and to refine the boundaries of the schizophrenia spectrum. Analyses of covariance structures in twin data have confirmed genetic susceptibility and recent life stresses as the major ...
openaire   +3 more sources

Genetic epidemiology of diabetes [PDF]

Journal of Clinical Investigation, 2005
Conventional genetic analysis focuses on the genes that account for specific phenotypes, while traditional epidemiology is more concerned with the environmental causes and risk factors related to traits. Genetic epidemiology is an alliance of the 2 fields that focuses on both genetics, including allelic variants in different populations, and ...
Permutt, M. Alan, Wasson, Jonathon, Cox, Nancy   +2 more
openaire   +3 more sources

STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology STROBE-ME: an extension of the STROBE statement. [PDF]

, 2011
Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change susceptibility and clinical outcomes are used as proxies for investigating the ...
David H. Phillips, Schoket, B, Peter B Farmer, Dep IRAS, G. Matullo (7601792), Vermeulen Roel, Giuseppe Matullo, Valentina Gallo, Kirsch-Volders, Micheline, B. Schoket (7601798), Porta Miquel, Kirsch-Volders, M, R. Vermeulen, Miquel Porta, Wild Christopher, Egger, M, Phillips, David, Gallo Valentina, Egger, M., Phillips, D.H., Phillips, DH, Vineis, P., Farmer, P.B., Porta, M, John P.A. Ioannidis, John P. A. Ioannidis, C. Wild, McCormack Valerie, Porta, Miquel, Porta, M., U. Stromberg (7601801), Lund University., M. Egger, Roel Vermeulen, Stromberg, U., Ioannidis, John P. A., Matullo, Giuseppe, Farmer, Peter B, P. Vineis (7601795), David H Phillips, Christopher Wild, McCormack, Valerie, Schoket Bernadette, B. Schoket, Farmer, PB, John P A Ioannidis, G. Matullo, Stromberg, U, Ioannidis, JP, Wild, C., Farmer, Peter B., Ulf Stromberg, Valerie McCormack, Matullo Giuseppe, V. Gallo (7601771), Vineis, Paolo, Loannidis, John P. A., D. H. Phillips (2298805), Gallo, Valentina, V. Mccormack (7601777), Wild, Christopher, V. Gallo, U. Stromberg, STROBE Statement, J. P. A. Ioannidis (7601786), M. Egger (7601774), P. B. Farmer, Matthias Egger, C. Wild (7601780), Schoket, B., V. McCormack, Strömberg, Ulf,, Gallo, V., P. Vineis, Gallo, V, Phillips, David H., Peter B. Farmer, Wild, C, Kirsch-Volders, M., R. Vermeulen (3788842), Phillips, David H, ?, ?, Stromberg, Ulf, McCormack, V., Phillips David H., M. Porta (7601804), Farmer Peter B., Ioannidis John P. A., M. Kirsch-Volders, Bernadette Schoket, Egger, Matthias, Egger Matthias, Ioannidis, John P A, McCormack, V, Vermeulen, Roel, Risk Assessment of Toxic and Immunomodulatory Agents, D. H. Phillips, Ioannidis, J.P., M. Porta, Matullo, G, Stromberg Ulf, Vineis Paolo, Vermeulen, R., Ioannidis, John PA, J. P. A. Ioannidis, M. Kirsch-Volders (7601789), Schoket, Bernadette, Matullo, G., P. B. Farmer (7601783), Vineis, P, STROBE Statement,, Kirsch-Volders Micheline, Micheline Kirsch-Volders, Porta, Miguel, Paolo Vineis, Vermeulen, R, Micheline Volders   +116 more
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Genetic Epidemiology of Asthma [PDF]

Epidemiologic Reviews, 1997
Asthma is an increasingly common disease in the developed world (1-3). In the United States, the second National Health and Nutrition Examination Survey (NHANES II) (1976-1980) estimates of asthma prevalence (4) were 6.9 percent for whites and 9.2 percent for blacks.
openaire   +3 more sources

Validation of differentially methylated microRNAs identified from an epigenome-wide association study; Sanger and next generation sequencing approaches

BMC Research Notes, 2018
Objectives Altered DNA methylation and microRNA profiles are associated with diabetic kidney disease. This study compared different sequencing approaches to define the genetic and epigenetic architecture of sequences surrounding microRNAs associated with
Laura J. Smyth, Alexander P. Maxwell, Katherine A. Benson, Jill Kilner, Gareth J. McKay, Amy Jayne McKnight   +5 more
doaj   +1 more source

KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies

BMC Bioinformatics, 2023
Background Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with kidney function. By combining these findings with post-GWAS information (e.g., statistical fine-mapping to identify independent association signals
Kira J. Stanzick, Klaus J. Stark, Mathias Gorski, Johannes Schödel, René Krüger, Florian Kronenberg, Richard Warth, Iris M. Heid, Thomas W. Winkler   +8 more
doaj   +1 more source

The enigmatic epidemiology of nasopharyngeal carcinoma [PDF]

, 2006
10.1158/1055-9965.EPI-06-0353Cancer Epidemiology Biomarkers and Prevention15101765 ...
Adami, H.-O., Chang, E.T., Chang, ET, Adami, H-O   +3 more
core   +1 more source