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Journal of the Royal College of Physicians of Edinburgh, 2012 The field of genetic epidemiology has advanced considerably over the past decade. The falling costs of genome-wide association studies have allowed the identification of many common genetic variants associated with risk of illness. This has advanced the understanding of disease pathogenesis but has not led to widespread changes in care.
J K, Dunbar, H, Campbell
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BMC Geriatrics, 2021 Background Loss of skeletal muscle mass and strength occurs with increasing age and is associated with loss of function, disability, and the development of sarcopenia and frailty.
Mary Ni Lochlainn +11 more
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Overcoming the Negligence in Laboratory Diagnosis of Mucosal Leishmaniasis
Pathogens, 2021 The northern region of Brazil, which has the largest number of cases of tegumentary leishmaniasis (TL) in the country, is also the region that has the highest diversity of species of vectors and Leishmania parasites.
Lilian Motta Cantanhêde +9 more
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Diverging destinies: ‘social’ data within the TwinsUK cohort [version 1; peer review: 2 approved]
Wellcome Open Research, 2022 Background: Twins offer social scientists a unique opportunity to understand the interplay of social factors and physical and mental well-being. TwinsUK is the largest UK registry of adult mono- and dy-zygotic twins, but most of the research that ...
Deborah Hart +8 more
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Annual Review of Genetics, 1993 Every science has roots that antedate acceptance as a discipline. Neglecting these intimations, there is a consensus that population genetics became a recognised science about 1920, and that it split into two branches about 1960. One branch is concerned with historical processes, uniting genetics with anthropology and (in other species) with ...
openaire +4 more sources
BMC Medical Genetics, 2020 Background Hereditary ophthalmic pathology is a genetically heterogeneous group of diseases that occur either as an isolated eye disorder or as a symptom of hereditary syndromes (chromosomal or monogenic).
Andrey V. Marakhonov +9 more
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BMC Genomic Data, 2023 Background Polygenic scores (PGSs) combining genetic variants found to be associated with creatinine-based estimated glomerular filtration rate (eGFRcrea) have been applied in various study populations with different age ranges.
Janina M. Herold +13 more
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Ecogeographic genetic epidemiology [PDF]
Genetic Epidemiology, 2008 AbstractComplex diseases such as cancer and heart disease result from interactions between an individual's genetics and environment, i.e. their human ecology. Rates of complex diseases have consistently demonstrated geographic patterns of incidence, or spatial “clusters” of increased incidence relative to the general population.
Chantel D, Sloan +6 more
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British Medical Bulletin, 1996 Studies of families, twins, and adoptees have helped to quantify the genetic contributions to and overlaps between depression, anxiety, phobias and alcoholism, and to refine the boundaries of the schizophrenia spectrum. Analyses of covariance structures in twin data have confirmed genetic susceptibility and recent life stresses as the major ...
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Combined association and linkage analysis applied to the APOE locus. [PDF]
, 2004 Combined association and linkage analysis is a powerful tool for pinpointing functional quantitative traits (QTLs) responsible for regions of significant linkage identified in genome-wide scans.
Abecasis +31 more
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