Results 1 to 10 of about 2,745,050 (303)

The PROMOTe study: targeting the gut microbiome with prebiotics to overcome age-related anabolic resistance: protocol for a double-blinded, randomised, placebo-controlled trial

BMC Geriatrics, 2021
Background Loss of skeletal muscle mass and strength occurs with increasing age and is associated with loss of function, disability, and the development of sarcopenia and frailty.
Mary Ni Lochlainn, Ayrun Nessa, Alyce Sheedy, Rachel Horsfall, María Paz García, Deborah Hart, Gulsah Akdag, Darioush Yarand, Samuel Wadge, Andrei-Florin Baleanu, Kevin Whelan, Claire Steves   +11 more
doaj   +1 more source

Overcoming the Negligence in Laboratory Diagnosis of Mucosal Leishmaniasis

Pathogens, 2021
The northern region of Brazil, which has the largest number of cases of tegumentary leishmaniasis (TL) in the country, is also the region that has the highest diversity of species of vectors and Leishmania parasites.
Lilian Motta Cantanhêde, Cristiane Batista Mattos, Ana Karoline Cruz, Yoda Janaina Ikenohuchi, Flavia Gonçalves Fernandes, Enmanuella Helga Ratier Terceiro Medeiros, Cipriano Ferreira da Silva-Júnior, Elisa Cupolillo, Gabriel Eduardo Melim Ferreira, Ricardo de Godoi Mattos Ferreira   +9 more
doaj   +1 more source

Diverging destinies: ‘social’ data within the TwinsUK cohort [version 1; peer review: 2 approved]

Wellcome Open Research, 2022
Background: Twins offer social scientists a unique opportunity to understand the interplay of social factors and physical and mental well-being. TwinsUK is the largest UK registry of adult mono- and dy-zygotic twins, but most of the research that ...
Deborah Hart, Ruth C E Bowyer, Ellen J Thompson, Andrew Anastasiou, Claire J Steves, Jennifer B Dowd, Golboo Abbasian, María Paz García, Genevieve Lachance   +8 more
doaj   +1 more source

Prenatal diagnosis of Norrie disease after whole exome sequencing of an affected proband during an ongoing pregnancy: a case report

BMC Medical Genetics, 2020
Background Hereditary ophthalmic pathology is a genetically heterogeneous group of diseases that occur either as an isolated eye disorder or as a symptom of hereditary syndromes (chromosomal or monogenic).
Andrey V. Marakhonov, Irina A. Mishina, Vitaly V. Kadyshev, Svetlana A. Repina, Maria F. Shurygina, Olga A. Shchagina, Natalya N. Vasserman, Tatyana A. Vasilyeva, Sergey I. Kutsev, Rena A. Zinchenko   +9 more
doaj   +1 more source

Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly – comparative results from the KORA and AugUR study

BMC Genomic Data, 2023
Background Polygenic scores (PGSs) combining genetic variants found to be associated with creatinine-based estimated glomerular filtration rate (eGFRcrea) have been applied in various study populations with different age ranges.
Janina M. Herold, Jana Nano, Mathias Gorski, Thomas W. Winkler, Kira J. Stanzick, Martina E. Zimmermann, Caroline Brandl, Annette Peters, Wolfgang Koenig, Ralph Burkhardt, André Gessner, Iris M. Heid, Christian Gieger, Klaus J. Stark   +13 more
doaj   +1 more source

Yoghurt consumption is associated with changes in the composition of the human gut microbiome and metabolome

BMC Microbiology, 2022
Background Yoghurt contains live bacteria that could contribute via modulation of the gut microbiota to its reported beneficial effects such as reduced body weight gain and lower incidence of type 2 diabetes.
Caroline Ivanne Le Roy, Alexander Kurilshikov, Emily R. Leeming, Alessia Visconti, Ruth C. E. Bowyer, Cristina Menni, Mario Fachi, Hana Koutnikova, Patrick Veiga, Alexandra Zhernakova, Mureil Derrien, Tim D. Spector   +11 more
doaj   +1 more source

An in-depth analysis of the mitochondrial phylogenetic landscape of Cambodia

Scientific Reports, 2021
Cambodia harbours a variety of human aboriginal populations that have scarcely been studied in terms of genetic diversity of entire mitochondrial genomes.
Anita Kloss-Brandstätter, Monika Summerer, David Horst, Basil Horst, Gertraud Streiter, Julia Raschenberger, Florian Kronenberg, Torpong Sanguansermsri, Jürgen Horst, Hansi Weissensteiner   +9 more
doaj   +1 more source

Changes in healthcare seeking and lifestyle in old aged individuals during COVID-19 lockdown in Germany: the population-based AugUR study

BMC Geriatrics, 2022
Background Containment measures in the COVID-19 pandemic protected individuals at high risk, particularly individuals at old age, but little is known about how these measures affected health-related behavior of old aged individuals.
Caroline Brandl, Martina E. Zimmermann, Felix Günther, Alexander Dietl, Helmut Küchenhoff, Julika Loss, Klaus J. Stark, Iris M. Heid   +7 more
doaj   +1 more source

Gut microbiota associations with common diseases and prescription medications in a population-based cohort

Nature Communications, 2018
The human gut microbiome has been associated with many health factors, but variability between studies limits exploration of these effects. Here, Jackson et al.
Matthew A. Jackson, Serena Verdi, Maria-Emanuela Maxan, Cheol Min Shin, Jonas Zierer, Ruth C. E. Bowyer, Tiphaine Martin, Frances M. K. Williams, Cristina Menni, Jordana T. Bell, Tim D. Spector, Claire J. Steves   +11 more
doaj   +1 more source

Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci

Nature Communications, 2018
Genomic polymorphisms affect the epigenome, which in turn influences how epigenome- and genome-wide analysis are interpreted. Here, the authors characterise allelic differences in DNA methylation driven by obligatory or facilitative genetic effects ...
Christopher G. Bell, Fei Gao, Wei Yuan, Leonie Roos, Richard J. Acton, Yudong Xia, Jordana Bell, Kirsten Ward, Massimo Mangino, Pirro G. Hysi, Jun Wang, Timothy D. Spector   +11 more
doaj   +1 more source