Results 61 to 70 of about 735,632 (337)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Genetic markers as instrumental variables: an application to child fat mass and academic achievement [PDF]

The use of genetic markers as instrumental variables (IV) is receiving increasing attention from economists. This paper examines the conditions that need to be met for genetic variants to be used as instruments.
Carol Propper, Debbie A. Lawlor, Frank Windmeijer, George Davey Smith, Stephanie von Hinke Kessler Scholder   +4 more
core   +3 more sources

Development of a Droplet Digital™ PCR DNA methylation detection and quantification assay of prenatal tobacco exposure

BioTechniques, 2022
DNA methylation is a labile modification associated with gene expression control and environmental adaptations. High throughput, scalable and quantitative assessments of specific DNA methylation modifications in complex genomic regions for use in large ...
Katti Arroyo, Anahit Nargizyan, Francianne G Andrade, Swe Swe Myint, Sabrina Lu, Priyatama Pandey, Amy Yee, Adam J de Smith, Joseph L Wiemels   +8 more
doaj   +1 more source

Role of Epidemiological Studies in Disease Prevention [PDF]

, 2019
Today's society is full of disease that are of different natures including genetic, infectious and metabolic etc. Every disease has its own mechanisms of affecting humans and different prevention mechanisms as per disease nature.
Akthar, M. S. (Muhammad)
core  

Comparative population structure of Plasmodium malariae and Plasmodium falciparum under different transmission settings in Malawi [PDF]

, 2011
<b>Background:</b> Described here is the first population genetic study of Plasmodium malariae, the causative agent of quartan malaria. Although not as deadly as Plasmodium falciparum, P.
Alex McConnachie, Allan Macheso, B Haubold, BS Weir, C Roper, CJ Sutherland, DJ Conway, E Kosman, FE McKenzie, HM Gilles, J Goudet, J May, JM Vinetz, K Maitland, K Mugittu, L Henning, LH Taylor, M Tanner, Malcolm E Molyneux, Marian C Bruce, MC Bruce, MC Bruce, MC Bruce, MC Bruce, MC Bruce, MU Ferreira, N Fraser-Hurt, N Tanomsing, PCC Garnham, R Tahar, RD Page, RL Ord, S Enosse, S Nair, S Zakeri, T Smith, T Smith, T Smith, T Smith, The Ministry of Health and Population, TJ Anderson, TJC Anderson, TL Ritchie, WE Collins, WJ Collins   +44 more
core   +4 more sources

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

Nature Communications, 2018
In GWAS, waist-to-hip ratio (WHR) is often adjusted for body mass index (BMI) to account for their correlation (WHRadjBMI). Here, Winkler et al. classify 159 genetic variants for BMI, WHR, or WHRadjBMI based on their effect directions for BMI and WHR to ...
Thomas W Winkler, Felix Günther, Simon Höllerer, Martina Zimmermann, Ruth JF Loos, Zoltán Kutalik, Iris M Heid   +6 more
doaj   +1 more source

Likelihood-Based Inference for Discretely Observed Birth-Death-Shift Processes, with Applications to Evolution of Mobile Genetic Elements

, 2014
Continuous-time birth-death-shift (BDS) processes are frequently used in stochastic modeling, with many applications in ecology and epidemiology. In particular, such processes can model evolutionary dynamics of transposable elements - important genetic ...
Biémont, Catlin, Cattamanchi, Crawford, Crawford, Dempster, Doss, Gagneux, Golinelli, Henrici, Huber, Kato-Maeda, Keiding, Lange, McEvoy, Minin, Rosenberg, Schwarz, Tanaka, Van Embden   +19 more
core   +1 more source

Associations between birth size and later height from infancy through adulthood : an individual based pooled analysis of 28 twin cohorts participating in the CODATwins project [PDF]

, 2018
Background: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment.
Abramson, Lior, Almqvist, Catarina, Bartels, Meike, Bayasgalan, Gombojav, Bjerregaard-Andersen, Morten, Boivin, Michel, Boomsma, Dorret I, Brandt, Ingunn, Brendgen, Mara, Brescianini, Sonia, Burt, S Alexandra, Corley, Robin P, Craig, Jeffrey M, Cutler, Tessa L, Derom, Catherine, Dionne, Ginette, Dubois, Lise, Fagnani, Corrado, Fisher, Abigail, Harris, Jennifer R, Haworth, Claire MA, Heikkila, Kauko, Hopper, John L, Huibregtse, Brooke M, Hur, Yoon-Mi, Jelenkovic, Aline, Ji, Fuling, Kaprio, Jaakko, Kim, Jina, Klump, Kelly L, Knafo-Noam, Ariel, Krueger, Robert F, Lee, Jooyeon, Lee, Sooji, Llewellyn, Clare H, Loos, Ruth JF, Magnusson, Patrik KE, Mankuta, David, McGue, Matt, Narandalai, Danshiitsoodol, Nelson, Tracy L, Nielsen, Henning Beck, Nilsen, Thomas Sevenius, Ning, Feng, Ooki, Syuichi, Pahlen, Shandell, Pang, Zengchang, Pietilainen, Kirsi H, Plomin, Robert, Rasmussen, Finn, Rebato, Esther, Saffery, Richard, Saudino, Kimberly J, Silventoinen, Karri, Sodemann, Morten, Sorensen, Thorkild IA, Stazi, Maria A, Sund, Reijo, Sung, Joohon, Tarnoki, Adam D, Tarnoki, David L, Tynelius, Per, Ullemar, Vilhelmina, van Beijsterveld, Catharina EM, Vitaro, Frank, Vlietinck, Robert F, Whitfield, Keith E, Willemsen, Gonneke, Yokoyama, Yoshie   +68 more
core   +6 more sources