Results 81 to 90 of about 731,889 (291)

Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers [PDF]

, 2007
Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level.
Mittelstrass, Kirstin, Ried, Janina S., Yu, Zhonghao, Krumsiek, Jan, Gieger, Christian, Prehn, Cornelia, Roemisch-Margl, Werner, Polonikov, Alexey, Peters, Annette, Theis, Fabian J., Meitinger, Thomas, Kronenberg, Florian, Weidinger, Stephan, Wichmann, Heinz-Erich, Suhre, Karsten, Wang-Sattler, Rui, Adamski, Jerzy, Illig, Thomas   +17 more
core   +2 more sources

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Tests in a Case-Control Design Including Relatives [PDF]

We present a new approach to handle dependencies within the general framework of case-control designs, illustrating our approach by a particular application from the field of genetic epidemiology.
Biedermann, Stefanie, Holzmann, Hajo, Munk, Axel, Nagel, Eva-Renate, Steland, Ansgar   +4 more
core  

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Nuclear and mitochondrial genetic variants associated with mitochondrial DNA copy number

Scientific Reports
Mitochondrial DNA copy number (mtDNA-CN) is a biomarker for mitochondrial dysfunction associated with several diseases. Previous genome-wide association studies (GWAS) have been performed to unravel underlying mechanisms of mtDNA-CN regulation.
Adriana Koller, Michele Filosi, Hansi Weissensteiner, Federica Fazzini, Mathias Gorski, Cristian Pattaro, Sebastian Schönherr, Lukas Forer, Janina M. Herold, Klaus J. Stark, Patricia Döttelmayer, Andrew A. Hicks, Peter P. Pramstaller, Reinhard Würzner, Kai-Uwe Eckardt, Iris M. Heid, Christian Fuchsberger, Claudia Lamina, Florian Kronenberg   +18 more
doaj   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

THE DESEASONALIZATION OF ANIMAL PRODUCTION [PDF]

We document the deseasonalization of animal production in the US and Europe. Hypotheses on causes and consequences of this trend are advanced. They pertain to feed costs, changes in animal productivity and cost fixity of the underlying technology ...
Hennessy, David A., Roosen, Jutta
core   +1 more source

The Parasite that Causes Whirling Disease, \u3cem\u3eMyxobolus cerebralis\u3c/em\u3e, is Genetically Variable Within and Across Spatial Scales [PDF]

, 2012
Understanding the genetic structure of parasite populations on the natural landscape can reveal important aspects of disease ecology and epidemiology and can indicate parasite dispersal across the landscape.
Kerans, Billie L., Lodh, Nilanjan, Stevens, Lori   +2 more
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Common inflammatory proteins linking frailty and area-level deprivation as key drivers of cardiovascular risk in women

Communications Medicine
Background Chronic inflammation is linked to frailty and deprivation, both of which are comorbid with cardiovascular diseases (CVD). This study aims to identify inflammatory proteins associated with both socioeconomic deprivation and frailty, and assess ...
Yu Lin, Panayiotis Louca, Ruth C. E. Bowyer, Afroditi Kouraki, Niccolò Rossi, Mary Ni Lochlainn, Anthony Kelly, Vasileios Georgopoulos, Frances M. K. Williams, Claire J. Steves, Mario Falchi, Ana M. Valdes, Cristina Menni   +12 more
doaj   +1 more source