Results 71 to 80 of about 2,745,050 (303)

Editorial for Special Issue “Genetic Basis and Epidemiology of Myopathies”

, 2021
We are pleased to announce a Special Issue on the Genetic Basis and Epidemiology of Myopathies. This Special Issue is collecting papers pertaining to various lines of research focusing on the genetic basis and the epidemiology of myopathies.
Efthimios Dardiotis, Eleni Peristeri, Peristeri E., Dardiotis E.   +2 more
core   +1 more source

A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

Nature Communications, 2018
In GWAS, waist-to-hip ratio (WHR) is often adjusted for body mass index (BMI) to account for their correlation (WHRadjBMI). Here, Winkler et al. classify 159 genetic variants for BMI, WHR, or WHRadjBMI based on their effect directions for BMI and WHR to ...
Thomas W Winkler, Felix Günther, Simon Höllerer, Martina Zimmermann, Ruth JF Loos, Zoltán Kutalik, Iris M Heid   +6 more
doaj   +1 more source

Genetic Epidemiology of BRCA1 [PDF]

Cancer Biology & Therapy, 2004
Since the identification of the BRCA1 gene 10 years ago much has been learned about the role of the BRCA1 protein in cancer development. In particular, genetic and epidemiological approaches have informed about the spectrum of mutations that occur in the gene and the prevalence, penetrance, and phenotype associated with these mutations in various ...
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Dietary intake, fatty acid in adipose tissue and cardio-metabolic health: cross-sectional study from the TwinsUK cohort

Nutrition & Diabetes
Background Subcutaneous adipose tissue, the largest fat depot buffering fatty acids, correlates with cardio-metabolic diseases. Diet plays a major role in fatty acid metabolism and correlates with cardio-metabolic diseases.
Xinyu Yan, Ricardo Costeira, Maryam Al-Hilal, Max Tomlinson, Panayiotis Louca, Emily R. Leeming, Cristina Menni, Thomas A. B. Sanders, Jordana T. Bell, Kerrin S. Small   +9 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Apolipoprotein A-IV concentrations and cancer in a large cohort of chronic kidney disease patients: results from the GCKD study

BMC Cancer
Background Chronic kidney disease (CKD) is highly connected to inflammation and oxidative stress. Both favour the development of cancer in CKD patients. Serum apolipoprotein A-IV (apoA-IV) concentrations are influenced by kidney function and are an early
Barbara Kollerits, Simon Gruber, Inga Steinbrenner, Johannes P. Schwaiger, Hansi Weissensteiner, Sebastian Schönherr, Lukas Forer, Fruzsina Kotsis, Ulla T. Schultheiss, Heike Meiselbach, Christoph Wanner, Kai-Uwe Eckardt, Florian Kronenberg, for the GCKD Investigators   +13 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Current Ethical and Social Issues in Epidemiology

, 2023
The American College of Epidemiology (ACE) held its 2021 Annual Meeting virtually, September 8-10, with a conference theme of "From Womb to Tomb: Insights from Health Emergencies". The ACE Ethics Committee hosted a symposium session in recognition of the
Salerno, Jennifer, Coughlin, Steven S, Hlaing, WayWay M, Goodman, Kenneth W   +3 more
core   +1 more source

Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome

Nature Communications
The interplay between diet and gut microbiome composition is complex. Faecal metabolites, the end products of human and microbial metabolism, provide insights into these interactions.
Robert Pope, Alessia Visconti, Xinyuan Zhang, Panayiotis Louca, Andrei-Florin Baleanu, Yu Lin, Francesco Asnicar, Kate Bermingham, Kari E. Wong, Gregory A. Michelotti, Jonathan Wolf, Nicola Segata, Sarah E. Berry, Tim D. Spector, Emily R. Leeming, Rachel Gibson, Cristina Menni, Mario Falchi   +17 more
doaj   +1 more source