Results 71 to 80 of about 17,950,884 (399)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Methods to Improve Joint Genetic Evaluation of Canine Hip Dysplasia Across BVA/KC and FCI Screening Schemes

Frontiers in Veterinary Science, 2020
The BVA/KC (British Veterinary Association/Kennel Club) and FCI (Fédération Cynologique Internationale) are the main screening schemes used to evaluate the status of canine hip dysplasia (HD) in Europe.
Shizhi Wang, Juliane Friedrich, Erling Strandberg, Per Arvelius, Pamela Wiener   +4 more
doaj   +1 more source

Evaluation of Genetic Diversity in Cacao Collected From Kolaka, Southeast Sulawesi, Using Ssr Markers [PDF]

, 2015
Kolaka, which is located in Southeast Sulawesi, has long been known as one of cacao production centers in Indonesia. Therefore, many different cacao germplasms can be found in this region.
Izzah, N. K. (Nur), Rubiyo, R. (Rubiyo), Sulistiyorini, I. (Indah), Tresniawati, C. (Cici)   +3 more
core  

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

A 16S RNA Analysis of Yangzhou Geese with Varying Body Weights: Gut Microbial Difference and Its Correlation with Body Weight Parameters

Animals
China is a major goose-raising country, and the geese industry plays a significant role in animal husbandry. Therefore, goose growth performance (body weight) is a critical topic.
Xinlei Xu, Suyu Fan, Hao Wu, Haoyu Li, Xiaoyu Shan, Mingfeng Wang, Yang Zhang, Qi Xu, Guohong Chen   +8 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Genetic Evaluation of Holsteins in Columbia

Journal of Dairy Science, 1986
Original data consisted of 31,777 records of progeny of 1442 sires for calvings between 1975 and 1983. Unadjusted means for milk yield (kg), days in milk, days dry, calving interval, days carried calf, and age at calving were 4281, 267, 88, 421, 145, and 36.6. Estimated total variance for first lactation milk yield by Henderson's method 3 was 1,385,436
Abubakar, B. Y., McDowell, R. E., Van Vleck, L. Dale   +2 more
openaire   +3 more sources

Biosimilars: State of Clinical and Regulatory Science

Journal of Pharmacy & Pharmaceutical Sciences, 2018
On May 12, 2017, various issues and challenges associated with biologics were discussed during a session of the annual joint conference of Canadian Society for Pharmaceutical Sciences and Canadian Chapter of Controlled Release Society at Hyatt Regency ...
Agnes Victoria Klein, Jian Wang, Brian G. Feagan, Mark Omoto   +3 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source