Results 91 to 100 of about 1,500,618 (293)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Artificial Intelligence Revolution in Transcriptomics: From Single Cells to Spatial Atlases
Advanced ScienceSingle‐cell RNA sequencing (scRNA‐seq) and spatial transcriptomics (ST) have revolutionized the study of cellular heterogeneity and tissue organization.
Shixin Li +7 more
doaj +1 more source
Cultural evolution developing its own rules: The rise of conservatism and persuasion [PDF]
, 2006 In the human sciences, cultural evolution is often viewed as an autonomous process free of genetic influence. A question that follows is, If culture is not influenced by genes, can it take any path?
Enquist, Magnus +2 more
core
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice
Nature CommunicationsGWASs have linked the 3p21.1 locus, which is associated with the expression levels of NEK4, to bipolar disorder. Here, we use integrative analyses of GWAS statistics and eQTL annotations to establish that elevated NEK4 expression in the hippocampus is ...
Zhi-Hui Yang +13 more
doaj +1 more source
Evolution of the discrete cosine transform using genetic programming [PDF]
, 2002 Compression of 2 dimensional data is important for the efficient transmission, storage and manipulation of Images. The most common technique used for lossy image compression relies on fast application of the Discrete Cosine Transform (DCT).
Cui, Xiang Biao, Johnson, Martin
core
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Evolution of genetic organization in digital organisms
, 1999 We examine the evolution of expression patterns and the organization of genetic information in populations of self-replicating digital organisms. Seeding the experiments with a linearly expressed ancestor, we witness the development of complex, parallel ...
Adami, Christoph, Ofria, Charles
core +1 more source
The evolution of genetic bandwagoning [PDF]
, 2016 Abstract Background In separate literatures, biologists have marshaled theoretical and empirical support for theories that a variant can be selected to (1) induce suicide by moribund or otherwise stressed holders; (2) induce suicide by a holder with low productive or reproductive potential; (3 ...
openaire +1 more source