Results 81 to 90 of about 4,927,397 (250)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Complex Adaptations and the Evolution of Evolvability

, 2005
Complex Adaptations and the Evolution of Evolvability +representation problem: "evolvability critically depends on the way genetic variation maps onto phenotypic variation" +Evidence that phenotypic variation is under genetic control: canalization ...
Altenberg, Lee, Wagner, Gunter P.
core  

Environmental factors influence both abundance and genetic diversity in a widespread bird species [PDF]

, 2013
Genetic diversity is one of the key evolutionary variables that correlate with population size, being of critical importance for population viability and the persistence of species. Genetic diversity can also have important ecological consequences within
Halvarsson, Peter, Halvarsson, P, Simone Webber, Halvarsson, Peter,, Katharine Bradley, Bradley, Katharine, Abdelgadir, Mohanad, Yang Liu, Mohanad Abdelgadir, Schmaltz, Lucie, Griesser, M, Katharine Bowgen, Abdelgadir, M, Lucie Schmaltz, Liu, Yang, Liu, Y., Schmaltz, L, Michael Griesser, Webber, Simone, Bowgen, Katharine, Webber, S., Bradley, K, Peter Halvarsson, Griesser, Michael, Abdelgadir, Mohanad,, Sveriges lantbruksuniversitet., Griesser, Michael,   +26 more
core   +2 more sources

Artificial Intelligence Revolution in Transcriptomics: From Single Cells to Spatial Atlases

Advanced Science
Single‐cell RNA sequencing (scRNA‐seq) and spatial transcriptomics (ST) have revolutionized the study of cellular heterogeneity and tissue organization.
Shixin Li, Tianxiang Xiao, Yuanyuan Lan, Chengxiao Wu, Zhouying Li, Rong Liu, Qing Fang, Chao Zhang   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Ecological causes of morphological evolution in the three-spined stickleback [PDF]

, 2013
The central assumption of evolutionary theory is that natural selection drives the adaptation of populations to local environmental conditions, resulting in the evolution of adaptive phenotypes.
C. Smith (2247166), Robert J. Wootton, Wootton, R.J., R. Spence (7654601), Mirosław Przybylski, Smith, Carl, Spence, Rowena Grace Alison, Iain Barber (348101), Rowena Spence, Iain Barber, Przybylski, Mirosław, Carl Smith, R. J. Wootton (7654604), Barber, Iain, M. Przybylski (2489125)   +14 more
core   +1 more source

NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice

Nature Communications
GWASs have linked the 3p21.1 locus, which is associated with the expression levels of NEK4, to bipolar disorder. Here, we use integrative analyses of GWAS statistics and eQTL annotations to establish that elevated NEK4 expression in the hippocampus is ...
Zhi-Hui Yang, Xin Cai, Chu-Yi Zhang, Qing Zhang, Miao Li, Zhong-Li Ding, Yingqi Guo, Guolan Ma, Chao-Hao Yang, Lei Guo, Hong Chang, Chuang Wang, Ming Li, Xiao Xiao   +13 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Genetic evolution of controllers for challenging control problems

, 2011
The automatic construction of controllers would be ideal in situations where traditional control theory and algorithms fail, as it is the case with certain dynamical systems.
Dracopoulos, D.
core   +1 more source

Inverse relationship between genetic diversity and epigenetic complexity [PDF]

, 2008
Early studies of molecular evolution revealed a correlation between genetic distance and time of species divergence. This observation provoked the molecular clock hypothesis and in turn the ‘Neutral Theory’, which however remains an ...
Shi Huang
core   +1 more source