Results 61 to 70 of about 1,500,618 (293)
FastMM: an efficient toolbox for personalized constraint-based metabolic modeling
BMC Bioinformatics, 2020 Background Constraint-based metabolic modeling has been applied to understand metabolism related disease mechanisms, to predict potential new drug targets and anti-metabolites, and to identify biomarkers of complex diseases.
Gong-Hua Li +5 more
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Genome Biology, 2023 Background Tibetans are genetically adapted to high-altitude environments. Though many studies have been conducted, the genetic basis of the adaptation remains elusive due to the poor reproducibility for detecting selective signatures in the Tibetan ...
Wangshan Zheng +19 more
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Frontiers in Cellular Neuroscience, 2022 Sensorineural hearing loss (SNHL) is referred to as the most common type of hearing loss and typically occurs when the inner ear or the auditory nerve is damaged.
Peng Chen +11 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke +4 more
wiley +1 more source
Regional and aging-specific cellular architecture of non-human primate brains
Genome MedicineBackground Deciphering the functionality and dynamics of brain networks across different regions and age groups in non-human primates (NHPs) is crucial for understanding the evolution of human cognition as well as the processes underlying brain ...
Yun-Mei Wang +15 more
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Open Computer Science, 2014 Abstract We present evolutionary approach to program development based on absorption of genetic strings at different metalevels. Introducing the principles of software evolution as processes of semantical stability, expansion and contraction, we continue with an example illustrating how it is possible to integrate metalevel with base ...
Ján Kollár, Emília Pietriková
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook +6 more
wiley +1 more source
Metabolic Adaptation to Following Temperature Acclimation in Fish on the Yun-Gui Plateau
BiologyTemperature is crucial for fish physiology, as metabolism and related physiological processes are directly influenced by thermal energy. Against the backdrop of global warming, climate-induced variations in water temperature increasingly constrain fish ...
Wei Dao +9 more
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Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets [PDF]
PeerJ, 2016 Ischemic stroke is a common neurological disorder and the burden in the world is growing. This study aims to explore the effect of sex and age difference on ischemic stroke using integrated microarray datasets. The results showed a dramatic difference in
Wen-Xing Li +9 more
doaj +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta +6 more
wiley +1 more source