Results 41 to 50 of about 1,488,947 (292)

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Canalization of the evolutionary trajectory of the human influenza virus [PDF]

, 2011
Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. Antigenic evolution occurs in the context of a two-dimensional 'antigenic map', while genetic evolution shows a characteristic ladder-like ...
A Kucharski, A Monto, A Park, A Rambaut, Andrew Rambaut, B Adams, B Finkelman, C Viboud, CA Russell, D Weinreich, DJ Smith, E Goldstein, E O'Dea, E Volz, F Carrat, F Tria, G Chowell, G Hirst, IG Barr, J Gog, J Lin, J O'Brien, J Truscott, J Voeten, K Koelle, K Koelle, K Koelle, K Koelle, M Recker, Mercedes Pascual, MI Nelson, NM Ferguson, R Bush, S Bhatt, S Gould, S Kryazhimskiy, S Park, T Bedford, T Bedford, Trevor Bedford, V Gupta, WM Fitch, YI Wolf, Z Yang   +43 more
core   +5 more sources

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

Fused in sarcoma (FUS) inhibits milk production efficiency in mammals

Nature Communications
Efficient milk production in mammals confers evolutionary advantages by facilitating the transmission of energy from mother to offspring. However, the regulatory mechanism responsible for the gradual establishment of milk production efficiency in mammals,
Haili Shao, Jipeng Huang, Hui Wang, Guolei Wang, Xu Yang, Mei Cheng, Changjie Sun, Li Zou, Qin Yang, Dandan Zhang, Zhen Liu, Xuelong Jiang, Lei Shi, Peng Shi, Baowei Han, Baowei Jiao   +15 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Experimental evidence for cancer resistance in a bat species

Nature Communications
Mammals exhibit different rates of cancer, with long-lived species generally showing greater resistance. Although bats have been suggested to be resistant to cancer due to their longevity, this has yet to be systematically examined.
Rong Hua, Yuan-Shuo Ma, Lu Yang, Jun-Jun Hao, Qin-Yang Hua, Lu-Ye Shi, Xiao-Qing Yao, Hao-Yu Zhi, Zhen Liu   +8 more
doaj   +1 more source

Mountains too high and valleys too deep drive population structuring and demographics in a Qinghai–Tibetan Plateau frog Nanorana pleskei (Dicroglossidae)

Ecology and Evolution, 2017
Pleistocene glacial–interglacial climatic oscillations greatly shaped the current genetic structure of many species. However, geographic features may influence the impact of climatic cycling.
Weiwei Zhou, Jieqiong Jin, Jun Wu, Hongman Chen, Junxiao Yang, Robert W. Murphy, Jing Che   +6 more
doaj   +1 more source

Correction to: FastMM: an efficient toolbox for personalized constraint-based metabolic modeling

BMC Bioinformatics, 2020
An amendment to this paper has been published and can be accessed via the original article.
Gong-Hua Li, Shaoxing Dai, Feifei Han, Wenxing Li, Jingfei Huang, Wenzhong Xiao   +5 more
doaj   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Single-cell expression profiling of bat wing development

Nature Communications
Bats are the only true-flight mammals, with wings formed by elongated digits and wing membranes. Despite the uniqueness, the cellular and molecular aspects of bat wing development remain largely unknown. Here, we use single-cell transcriptomic sequencing
Xue Lyu, Jing Bai, Ji-Bin Jiang, Chang-Jie Sun, Peng Chen, Qi Liu, Yuan-Shuo Ma, Zhen Liu   +7 more
doaj   +1 more source