Results 31 to 40 of about 1,488,947 (292)

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer. [PDF]

, 2017
Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution.
Bivona, Trever G, Cai, Mei-Chun, Chen, Hong-Zhuan, Chen, Minjiang, Fu, Yujie, Gao, Wei-Qiang, Gu, Zhenyu, Jing, Ying, Ma, Pengfei, Shen, Ying, Wang, Mengzhao, Wu, Jie, Yan, Ying, Zhang, Shengzhe, Zhao, Xiaojing, Zhu, Liang, Zhuang, Guanglei   +16 more
core   +2 more sources

The asexual genome of Drosophila

, 2017
The rate of recombination affects the mode of molecular evolution. In high-recombining sequence, the targets of selection are individual genetic loci; under low recombination, selection collectively acts on large, genetically linked genomic segments ...
Lässig, Michael, Mustonen, Ville, Schiffels, Stephan   +2 more
core   +1 more source

Long-read assembly of the Chinese rhesus macaque genome and identification of ape-specific structural variants

Nature Communications, 2019
Comparative genomic analysis of human and primate relatives can reveal important biological and evolutionary insights. Here, the authors present a long-read assembly of the Chinese rhesus macaque genome and identify ape-specific structural variants.
Yaoxi He, Xin Luo, Bin Zhou, Ting Hu, Xiaoyu Meng, Peter A. Audano, Zev N. Kronenberg, Evan E. Eichler, Jie Jin, Yongbo Guo, Yanan Yang, Xuebin Qi, Bing Su   +12 more
doaj   +1 more source

Phase Diagrams of Quasispecies Theory with Recombination and Horizontal Gene Transfer

, 2006
We consider how transfer of genetic information between individuals influences the phase diagram and mean fitness of both the Eigen and the parallel, or Crow-Kimura, models of evolution.
J. Maynard, J.-M. Park, J. F. Crow, K. Jain, M. W. Deem   +4 more
core   +1 more source

Spatial connectedness imposes local‐ and metapopulation‐level selection on life history through feedbacks on demography

, 2020
Dispersal evolution impacts the fluxes of individuals and hence, connectivity in metapopulations. Connectivity is therefore decoupled from the structural connectedness of the patches within the spatial network.
Helle W., Johst K., Li X.‐Y., Rossetti M.R., Rudnick D.   +4 more
core   +1 more source

A high-quality genome assembly of the Spectacled Fulvetta (Fulvetta ruficapilla) endemic to China

Scientific Data
The Spectacled Fulvetta (Fulvetta ruficapilla) is the type species of Fulvetta, an evolutionarily distinct group whose species show a high degree of sympatry in distribution and phenotypic convergence.
Chen Yan, Si Si, Hong-Man Chen, Yu-Ting Zhang, Lu-Ming Liu, Fei Wu, Ming-Shan Wang   +6 more
doaj   +1 more source

Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats

iScience, 2022
Summary: The laryngeal echolocation is regarded as one of the conspicuous traits that play major roles in flourishing bats. Whether the laryngeal echolocation in bats originated once, however, is still controversial.
Zhen Liu, Peng Chen, Dong-Ming Xu, Fei-Yan Qi, Yuan-Ting Guo, Qi Liu, Jing Bai, Xin Zhou, Peng Shi   +8 more
doaj   +1 more source

Genetic Counselling: Evolution or Involution?

Public Health Genomics, 2000
The need for genetic counselling derives from the peculiarities of genetic information, as compared to other biomedical tests, with particular reference to (a) its predictive character; (b) the existing gap between the ability to diagnose and to treat an inherited disorder, and (c) the psychological, social and ethical problems that genetic testing can
Frontali M., Jacopini A.G.
openaire   +3 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Non-equilibrium time dynamics of genetic evolution

, 2018
Biological systems are typically highly open, non-equilibrium systems that are very challenging to understand from a statistical mechanics perspective.
Birman, Liev, Byrnes, Tim, Nehme, Samer Intissar, Radhakrishnan, Chandrashekar, Rastegar-Sedehi, Hamid-Reza, Velasquez, Paula   +5 more
core   +1 more source