Results 51 to 60 of about 1,488,947 (292)

An investigation of the prevalence of Giardia agilis in anuran amphibians from fourteen areas in China

open access: yesInternational Journal for Parasitology: Parasites and Wildlife, 2020
Giardia agilis is a Giardia species which is morphological distinguishable for its very narrow and elongated trophozoite. Although there were a few studies about its morphology since its first report in 1882, none investigations about its prevalence have
Zhangxia Lyu   +5 more
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Complete mitochondrial genome sequence for the Cercopithecus erythrotis camerunensis (Primate: Cercopithecidae)

open access: yesMitochondrial DNA. Part B. Resources, 2019
Cercopithecus erythrotis camerunensis a subspecies of Cercopithecus erythrotis, endemic primate to West Africa, is listed as a vulnerable species under the IUCN red list, due to a rapid population decline resulting from intense hunting, bushmeat trade ...
Adeola O. Ayoola   +5 more
doaj   +1 more source

Zebrafish as an alternative animal model in human and animal vaccination research

open access: yesLaboratory Animal Research, 2020
Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies.
Ricardo Lacava Bailone   +8 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

FastMM: an efficient toolbox for personalized constraint-based metabolic modeling

open access: yesBMC Bioinformatics, 2020
Background Constraint-based metabolic modeling has been applied to understand metabolism related disease mechanisms, to predict potential new drug targets and anti-metabolites, and to identify biomarkers of complex diseases.
Gong-Hua Li   +5 more
doaj   +1 more source

Large-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans

open access: yesGenome Biology, 2023
Background Tibetans are genetically adapted to high-altitude environments. Though many studies have been conducted, the genetic basis of the adaptation remains elusive due to the poor reproducibility for detecting selective signatures in the Tibetan ...
Wangshan Zheng   +19 more
doaj   +1 more source

Integrative Functional Transcriptomic Analyses Implicate Shared Molecular Circuits in Sensorineural Hearing Loss

open access: yesFrontiers in Cellular Neuroscience, 2022
Sensorineural hearing loss (SNHL) is referred to as the most common type of hearing loss and typically occurs when the inner ear or the auditory nerve is damaged.
Peng Chen   +11 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

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