Results 101 to 110 of about 213,884 (312)
, 2014 This work was supported by funding from Balliol College, the Royal Society (A.G.), and the University of Groningen (L.R.).There has been much recent interest in the role for genetic conflicts to drive the evolution of genetic systems.
Ross, Laura, Gardner, Andy
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An experimental comparative study for interactive evolutionary computation problems [PDF]
, 2006 Proceeding of: EvoWorkshops 2006: EvoBIO, EvoCOMNET, EvoHOT, EvoIASP, EvoINTERACTION, EvoMUSART, and EvoSTOC, Budapest, Hungary, April 10-12, 2006This paper presents an objective experimental comparative study between four algorithms: the Genetic ...
Sáez, Yago +9 more
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Genetic stereo matching algorithm with fuzzy fitness [PDF]
2014 6th International Conference of Soft Computing and Pattern Recognition (SoCPaR), 2014 This paper presents a genetic stereo matching algorithm with fuzzy evaluation function. The proposed algorithm presents a new encoding scheme in which a chromosome is represented by a disparity matrix. Evolution is controlled by a fuzzy fitness function able to deal with noise and uncertain camera measurements, and uses classical evolutionary operators.
openaire +3 more sources
Heterogeneous Adaptive Trajectories of Small Populations on Complex Fitness Landscapes
, 2008 Background Small populations are thought to be adaptively handicapped, not only because they suffer more from deleterious mutations but also because they have limited access to new beneficial mutations, particularly those conferring large benefits ...
J Arjan G M de Visser +12 more
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Fitness uniform selection to preserve genetic diversity [PDF]
Proceedings of the 2002 Congress on Evolutionary Computation. CEC'02 (Cat. No.02TH8600), 2003 13 LaTeX pages, 1 eps ...
openaire +2 more sources
Using Fitness Value for Monitoring Kiwifruit’s Variant Seedling in Tissue Culture
Cybernetics and Information Technologies, 2016 Based on Genetic Algorithm, a pattern recognition approach using fitness to dynamically monitor the sub cultured seeding of kiwifruit is proposed in order to decrease the loss of variant seedlings in tissue culture.
Tang Shouguo, Li Yong, Zhang Zhikun
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source